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中國(guó)漢族人群補(bǔ)體因子H的基因多態(tài)性與精神分裂癥的關(guān)聯(lián)研究

發(fā)布時(shí)間:2018-05-22 08:37

  本文選題:精神分裂癥 + 補(bǔ)體因子H基因 ; 參考:《上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年07期


【摘要】:目的·探討中國(guó)漢族人群補(bǔ)體因子H(CFH)基因單核苷酸多態(tài)性(SNP)位點(diǎn)與精神分裂癥的相關(guān)性。方法·采用SNa Pshot法,對(duì)418例精神分裂癥患者(病例組)和655個(gè)正常健康人(正常對(duì)照組)CFH基因5個(gè)SNP位點(diǎn)(rs800292、rs1061170、rs10801555、rs10922096、rs2019727)的基因型、等位基因、單體型頻率進(jìn)行比較。結(jié)果·成功檢測(cè)5個(gè)SNP位點(diǎn)的基因型,關(guān)聯(lián)分析顯示rs1061170位點(diǎn)等位基因頻率分布在病例組和對(duì)照組之間差異有統(tǒng)計(jì)學(xué)意義(校正P值=0.045),其他位點(diǎn)的基因型和等位基因頻率分布在2組間差異均無(wú)統(tǒng)計(jì)學(xué)意義(均校正P值0.05)。由rs800292-rs1061170-rs10801555-rs10922096-rs2019727組成的單體型C-A-T-A-A頻率分布在2組之間的差異有統(tǒng)計(jì)學(xué)意義(校正P值=0.013)。結(jié)論·CFH基因rs1061170位點(diǎn)等位基因多態(tài)性以及rs800292-rs1061170-rs10801555-rs10922096-rs2019727單體型C-A-T-A-A可能與中國(guó)漢族人群中的精神分裂癥發(fā)病有關(guān)。
[Abstract]:Objective to investigate the association between SNPs of complement factor HG CFH gene and schizophrenia in Chinese Han population. Methods the genotypes, alleles and haplotype frequencies of 418 schizophrenic patients (case group) and 655 normal controls (5 SNP loci of the normal control group) were compared by SNa Pshot method. Results the genotypes of 5 SNP loci were detected successfully. Correlation analysis showed that the allelic frequency distribution of rs1061170 locus was significantly different between the two groups (P = 0.045, P = 0.045), but there was no significant difference in genotype and allele frequency distribution between the two groups. (P = 0.05). The frequency distribution of haplotype C-A-T-A-A composed of rs800292-rs1061170-rs10801555-rs10922096-rs2019727 was significantly different between the two groups (P = 0.013). Conclusion the allelic polymorphism of rs1061170 locus of CFH gene and rs800292-rs1061170-rs10801555-rs10922096-rs2019727 haplotype C-A-T-A-A may be associated with schizophrenia in Chinese Han population.
【作者單位】: 上海交通大學(xué)醫(yī)學(xué)院附屬精神衛(wèi)生中心;
【基金】:國(guó)家自然科學(xué)基金(81671326) 國(guó)家重點(diǎn)研發(fā)計(jì)劃“精準(zhǔn)醫(yī)學(xué)研究”重點(diǎn)專項(xiàng)(2016YFC0906402) 上海市科學(xué)技術(shù)委員會(huì)科研計(jì)劃項(xiàng)目(17411970000) 中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)(16JXRZ06) 上海市精神衛(wèi)生中心院級(jí)國(guó)際合作項(xiàng)目(2015-YJGJ-03)~~
【分類號(hào)】:R749.3
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