本文選題：阿爾茨海默病 + SB蛋白　； 參考：《中國心理衛(wèi)生雜志》2017年07期

【摘要】：目的:分析阿爾茨海默病(AD)患者血清S100B、抗腦抗體(ABAb)濃度變化及其與認(rèn)知功能、生活能力間的關(guān)系,探討S100B、ABAb在AD發(fā)病機(jī)制中可能的作用。方法:研究共納入符合美國精神障礙診斷與統(tǒng)計(jì)手冊(cè)第IV版(DSM-IV)AD診斷的患者32例(AD組),無認(rèn)知障礙老年對(duì)照40例(對(duì)照組)。采用簡(jiǎn)易智能精神狀態(tài)檢查量表(MMSE)、日常生活能力量表(ADL)評(píng)估所有研究對(duì)象認(rèn)知功能和生活能力,采用阿爾茨海默病評(píng)定量表認(rèn)知分量表(ADAS-Cog)進(jìn)一步評(píng)定AD患者的認(rèn)知功能;應(yīng)用酶聯(lián)免疫吸附法(ELISA)檢測(cè)血清S100B、ABAb濃度。結(jié)果:AD組血清S100B[(0.66±0.17)μg/L vs.(0.30±0.04)μg/L]、ABAb[(1.93±0.95)U/L vs.(1.31±0.25)U/L]濃度高于對(duì)照組(均P0.01);AD組血清S100B濃度與MMSE總分負(fù)相關(guān)(r=-0.66),與ADAS-Cog總分、ADL評(píng)分呈正相關(guān)(r=0.57,r=0.53)(均P0.005);血清ABAb濃度與MMSE總分呈負(fù)相關(guān)(r=-0.57),與ADAS-Cog總分、ADL評(píng)分呈正相關(guān)(r=0.52,r=0.34)(均P0.05);AD組血清S100B與ABAb濃度正相關(guān)(r=0.51,P0.005),在對(duì)照組中并未發(fā)現(xiàn)此相關(guān)關(guān)系(r=0.076,P0.05)。結(jié)論:AD患者血清S100B、ABAb水平與認(rèn)知損傷程度相關(guān),提示S100B、ABAb可能在AD發(fā)病機(jī)制中起一定作用。
[Abstract]:Objective: to analyze the changes of serum S100B, anti-brain antibody ABAband their relationship with cognitive function and living ability in patients with Alzheimer's disease (AD), and to explore the possible role of S100B ABAb in the pathogenesis of AD. Methods: a total of 32 patients with AD and 40 elderly controls without cognitive impairment were enrolled in the study. The cognitive function and life ability of all the subjects were evaluated by MMSE and ADL, and the cognitive function of AD patients was further evaluated by ADAS-Cog-ADAS-Cog. Elisa was used to detect the concentration of serum S100 BX ABAb. 緇撴灉:AD緇勮娓匰100B[(0.66鹵0.17)渭g/L vs.(0.30鹵0.04)渭g/L],ABAb[(1.93鹵0.95)U/L vs.(1.31鹵0.25)U/L]嫻撳害楂樹簬瀵圭収緇，

本文編號(hào)：1899447