本文選題：吸毒 + 海洛因　； 參考：《安徽醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的：毒品進(jìn)入機(jī)體后可致多系統(tǒng)發(fā)生病變。吸毒人員普遍存在消化道癥狀,影響吸毒人員的營(yíng)養(yǎng)狀況,營(yíng)養(yǎng)不良發(fā)生率高。營(yíng)養(yǎng)不良可影響吸毒人員的康復(fù)治療和導(dǎo)致復(fù)吸。因此,全面了解和評(píng)估吸毒人員的營(yíng)養(yǎng)狀況,給予營(yíng)養(yǎng)支持促進(jìn)吸毒人員的康復(fù)具有重要的意義。另一方面,生長(zhǎng)激素釋放肽(Ghrelin)和瘦素(Leptin)是兩種參與機(jī)體能量代謝的激素,兩者的變化均可影響機(jī)體的營(yíng)養(yǎng)狀況。因此本研究通過調(diào)查100名吸毒人員臨床資料和消化道癥狀發(fā)生情況,評(píng)估吸毒人員的營(yíng)養(yǎng)狀況,同時(shí)檢測(cè)吸毒人員血清Ghrelin和Leptin水平,以探討吸毒人員發(fā)生營(yíng)養(yǎng)不良有關(guān)機(jī)制,為戒毒治療提供新思路。 方法：采用精神活性物質(zhì)濫用者基本情況調(diào)查表、簡(jiǎn)易營(yíng)養(yǎng)評(píng)價(jià)法(MNA)對(duì)100名吸毒人員進(jìn)行問卷調(diào)查和營(yíng)養(yǎng)評(píng)價(jià),同時(shí)采用問卷形式調(diào)查吸毒人員的消化道癥狀。利用酶聯(lián)免疫吸附法(ELISA)檢測(cè)100名吸毒人員和25名對(duì)照組血清中Ghrelin和Leptin水平。 結(jié)果：100名吸毒人員中,60名海洛因吸食者,40名冰毒吸食者。60名海洛因吸食者中燙吸23例,肌肉注射10例,靜脈注射27例；吸食時(shí)間為12-158月；在消化道癥狀中,便秘53例(88.3%),嘔吐50例(83.3%),腹瀉38例(63.3%),腹脹15例(25%),腹痛20例(33.3%)；利用MNA評(píng)估發(fā)現(xiàn),營(yíng)養(yǎng)不良者40例(66.7%),存在營(yíng)養(yǎng)不良風(fēng)險(xiǎn)者19例(31.7%),營(yíng)養(yǎng)良好者1例(1.6%)。40名冰毒吸食者中采用冰壺吸食；吸食時(shí)間為2-40月；在消化道癥狀中,嘔吐18例(45.0%),腹瀉11例(27.5%),腹痛9例(22.5%),腹脹16例(40.0%),便秘20例(50.0%)；利用MNA評(píng)價(jià)發(fā)現(xiàn),營(yíng)養(yǎng)不良者24例(60.0%),存在營(yíng)養(yǎng)不良風(fēng)險(xiǎn)者9例(22.5%),營(yíng)養(yǎng)良好者7例(17.5%)。有無營(yíng)養(yǎng)不良風(fēng)險(xiǎn)與吸毒方式、吸毒時(shí)間組間比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05),與消化道癥狀、毒品的種類組間比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 吸毒人員血清Ghrelin水平低于對(duì)照組(640.49±93.57pg/ml vs1072.12±209.5pg/ml,p0.05);冰毒吸食組高于海洛因吸食組(p0.05)；無消化道癥狀組高于有消化道癥狀組(p0.05)；無營(yíng)養(yǎng)不良組高于營(yíng)養(yǎng)不良組(p0.05)無營(yíng)養(yǎng)不良風(fēng)險(xiǎn)組高于存在營(yíng)養(yǎng)不良風(fēng)險(xiǎn)組(p0.05)。 吸毒人員血清Leptin水平高于對(duì)照組(463.96±96.72pg/ml vs333.47±77.47pg/ml,p0.05)；海洛因吸食組高于冰毒吸食組(p0.05)；有消化道癥狀組高于無癥狀組(p0.05)；營(yíng)養(yǎng)不良組于無營(yíng)養(yǎng)不良組(p0.05)；存在營(yíng)養(yǎng)不良風(fēng)險(xiǎn)組高于無營(yíng)養(yǎng)不良風(fēng)險(xiǎn)組(p0.05)。不同吸毒方式和吸毒時(shí)間組間血Ghrelin和Leptin比較,差異無統(tǒng)計(jì)學(xué)意義(p0.05)。 結(jié)論：100名吸毒人員有不同程度的消化道癥狀,多數(shù)存在營(yíng)養(yǎng)不良和營(yíng)養(yǎng)不良風(fēng)險(xiǎn),提示吸毒人員進(jìn)行營(yíng)養(yǎng)評(píng)估和營(yíng)養(yǎng)支持,促進(jìn)康復(fù)治療,具有重要的意義。吸毒人員血清Ghrelin和1Leptin水平改變,提示可能參與吸毒人員營(yíng)養(yǎng)不良的發(fā)生過程。
[Abstract]:Objective: drugs can cause multiple system lesions when they enter the body. The prevalence of digestive tract symptoms in drug addicts affects their nutritional status and the incidence of malnutrition is high. Malnutrition can affect the rehabilitation of drug addicts and lead to relapse. Therefore, comprehensive understanding and evaluation of the nutritional status of drug addicts, nutritional support to promote the rehabilitation of drug addicts has important significance. On the other hand, growth hormone releasing peptide (ghrelin) and leptin (Leptin) are two hormones involved in energy metabolism. Therefore, this study investigated the clinical data and digestive tract symptoms of 100 drug addicts, assessed the nutritional status of drug addicts, and detected the serum levels of Ghrelin and Leptin in drug addicts in order to explore the mechanism of malnutrition among drug addicts. To provide new ideas for drug treatment. Methods: the questionnaire of psychoactive substance abusers and the simple nutrition evaluation method MNAwere used to investigate the symptoms of digestive tract of 100 drug addicts. The serum levels of Ghrelin and Leptin were measured by Elisa in 100 drug addicts and 25 controls. Results among the 100 drug addicts, 60 heroin addicts and 40 methamphetamine addicts. Among the 60 heroin addicts, 23 were burned, 10 were injected intramuscularly and 27 were injected intravenously. The smoking time was 12-158 months. There were 53 cases with constipation, 50 cases with vomiting, 38 cases with diarrhea and 63.3%, 15 cases with abdominal distension and 25 cases with abdominal pain, 20 cases with abdominal pain, 40 cases with malnutrition, 19 cases with risk of malnutrition, and 1 case with good nutrition. The smoking time was 2-40 months, among which 18 cases had vomiting, 11 cases had diarrhea, 9 cases had abdominal pain, 9 cases had abdominal pain, 16 cases had abdominal distension and 40.0m, 20 cases had constipation, 24 cases had malnutrition, 9 cases had malnutrition risk, 7 cases had good nutrition, 7 cases had good nutrition, 20 cases had constipation, 24 cases had malnutrition, 9 cases had malnutrition risk, and 7 cases had good nutrition. There was no significant difference in the risk of malnutrition and drug use, and there was no significant difference in drug use time group (P 0.05), but there was significant difference between the groups with digestive tract symptoms and drug types (P 0.05). The serum Ghrelin level of drug addicts was lower than that of control group (640.49 鹵209.5pg / ml 路ml / ml), the level of meth addiction was higher than that of heroin addicts (P 0.05), the digestive tract symptom group was higher than that of digestive tract symptom group (P 0.05), the malnutrition group was higher than that of malnutrition group (p 0.05) and the risk group of malnutrition was higher than that of non-dystrophy group (P < 0.05). In the group with malnutrition risk, p0.05. The serum Leptin level of drug addicts was higher than that of the control group (463.96 鹵77.47pg / ml), the heroin group was higher than the meth addiction group (P 0.05), the digestive tract symptom group was higher than the asymptomatic group (p 0.05), the malnutrition group was higher than that of the control group (p 0.05), and the risk group of malnutrition was higher than that of the non-malnutrition risk group (P 0.05). There was no significant difference in blood Ghrelin and Leptin between different drug use methods and drug use time groups (P 0.05). Conclusion 100 drug addicts have different digestive tract symptoms, and most of them have malnutrition and malnutrition risk, which suggests that it is important for drug addicts to carry out nutritional evaluation and nutritional support and promote rehabilitation treatment. The changes of serum Ghrelin and 1Leptin levels suggest that drug addicts may be involved in the process of malnutrition.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.64

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張昭馥,臧貴明,付芳婷,趙麗,趙云濤,張肇康;血液透析患者血漿Ghrelin測(cè)定的初步分析[J];中華腎臟病雜志;2002年01期

2 李華琦,童南偉;促生長(zhǎng)激素分泌的新多肽——Ghrelin[J];中華內(nèi)分泌代謝雜志;2003年05期

3 張昭馥,臧貴明,付芳婷,趙麗,趙云濤,張肇康;血液透析對(duì)血漿Ghrelin的影響[J];第三軍醫(yī)大學(xué)學(xué)報(bào);2002年09期

4 張興平,陳慶偉;Ghrelin與慢性心力衰竭[J];心血管病學(xué)進(jìn)展;2005年06期

5 Avsian-Kretchmer O;林益華;;肥胖抑素與Ghrelin[J];中國(guó)糖尿病雜志;2007年02期

6 付曉輝,劉戈力;ghrelin影響機(jī)體肥胖和能量平衡的作用及其調(diào)節(jié)機(jī)制[J];國(guó)外醫(yī)學(xué).兒科學(xué)分冊(cè);2004年S1期

7 竇家慶;章秋;;Ghrelin與骨質(zhì)疏松[J];安徽醫(yī)藥;2009年07期

8 余躍;王巧民;;Ghrelin與胃腸運(yùn)動(dòng)[J];世界華人消化雜志;2006年23期

9 淺川明弘 ,劉榮有;攝食與腦-腸相關(guān) 一、一種新的消化管激素Ghrelin[J];日本醫(yī)學(xué)介紹;2002年09期

10 何蓮;張愛華;;慢性腎臟疾病與透析患者ghrelin研究現(xiàn)狀[J];中國(guó)血液凈化;2005年12期

相關(guān)會(huì)議論文 前10條

1 余燕;馬金友;張青占;王天有;;Ghrelin免疫陽性細(xì)胞在白萊航蛋雞胸腺內(nèi)的定位與發(fā)育性變化[A];中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物解剖學(xué)及組織胚胎學(xué)分會(huì)第十六次學(xué)術(shù)研討會(huì)論文集[C];2010年

2 毛峗杰;林金杏;曾衛(wèi)東;張才喬;;Ghrelin對(duì)雞等級(jí)前卵泡發(fā)育的影響[A];全國(guó)動(dòng)物生理生化第十一次學(xué)術(shù)交流會(huì)論文摘要匯編[C];2010年

3 蘇娟;雷治海;張文龍;武楓林;施玉萍;姚遠(yuǎn);楊桂紅;;Ghrelin對(duì)豬生殖調(diào)節(jié)的體外研究[A];中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物解剖學(xué)及組織胚胎學(xué)分會(huì)第十六次學(xué)術(shù)研討會(huì)論文集[C];2010年

4 蔣書東;李福寶;楊靜;羅英霞;方富貴;;Ghrelin在青春期和妊娠期小鼠卵巢與子宮的定位[A];中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物解剖學(xué)及組織胚胎學(xué)分會(huì)第十六次學(xué)術(shù)研討會(huì)論文集[C];2010年

5 陳黎龍;江青艷;傅偉龍;;Ghrelin及其受體研究概況[A];動(dòng)物生理生化學(xué)分會(huì)第八次學(xué)術(shù)會(huì)議暨全國(guó)反芻動(dòng)物營(yíng)養(yǎng)生理生化第三次學(xué)術(shù)研討會(huì)論文摘要匯編[C];2004年

6 楊連玉;楊文艷;秦貴信;王哲;;日糧銅對(duì)豬胃底Ghrelin分泌的影響[A];中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物營(yíng)養(yǎng)學(xué)分會(huì)——第九屆學(xué)術(shù)研討會(huì)論文集[C];2004年

7 高美娟;楊進(jìn);劉國(guó)強(qiáng);魏蕊;侯文芳;朱明霞;陳貴安;洪天配;;GHS-R1a亞型不參與介導(dǎo)Ghrelin促進(jìn)心肌細(xì)胞分化的作用[A];中華醫(yī)學(xué)會(huì)第十次全國(guó)內(nèi)分泌學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2011年

8 王云開;黎蘭芳;魏云峰;王夢(mèng)洪;鄭澤琪;彭景添;彭小平;;Ghrelin對(duì)AngⅡ所致人臍靜脈內(nèi)皮細(xì)胞損傷的保護(hù)作用研究[A];江西省第四次中西醫(yī)結(jié)合心血管學(xué)術(shù)交流會(huì)論文集[C];2008年

9 張繼光;桑優(yōu)芬;;吸毒人員文身情競(jìng)介紹[A];浙江省醫(yī)師協(xié)會(huì)精神科醫(yī)師分會(huì)成立大會(huì)暨二○○八年浙江省精神病學(xué)學(xué)術(shù)年會(huì)論文匯編[C];2008年

10 趙潔;張金山;李臻;張遠(yuǎn)強(qiáng);;Ghrelin對(duì)LPS誘導(dǎo)小鼠EL-4胸腺細(xì)胞凋亡的調(diào)節(jié)作用[A];中國(guó)解剖學(xué)會(huì)2011年年會(huì)論文文摘匯編[C];2011年

相關(guān)重要報(bào)紙文章 前10條

1 記者　黃雄展;禁毒形勢(shì)依然嚴(yán)峻[N];福州日?qǐng)?bào);2006年

2 鐘明建 黃忠前;隴川公安邊防大隊(duì)收戒吸毒人員15名[N];云南經(jīng)濟(jì)日?qǐng)?bào);2006年

3 本報(bào)記者 羅安宇;戒斷鞏固率穩(wěn)步提高[N];貴陽日?qǐng)?bào);2008年

4 記者 郭曼;30秒讓癮君子無處遁形[N];昆明日?qǐng)?bào);2009年

5 本版組稿 李錆，

本文編號(hào)：1889079