發(fā)布時間：2018-05-14 03:23

  本文選題：癡呆 + 酒精性神經(jīng)病　； 參考：《中國神經(jīng)免疫學和神經(jīng)病學雜志》2014年05期

【摘要】：酒精中毒是誘導癡呆發(fā)病的重要因素。近年來研究證實酒精干擾成年海馬神經(jīng)發(fā)生與誘導癡呆發(fā)病密切相關。酒精可通過抑制成年海馬新生神經(jīng)元的發(fā)生過程而影響學習記憶功能調控,其具體作用機制包括誘導促進神經(jīng)炎性反應、抑制神經(jīng)營養(yǎng)因子表達及干擾神經(jīng)干細胞增殖分化相關信號通路等。目前針對酒精性癡呆患者的治療手段有限且治療效果不佳,因此深入闡明酒精導致學習記憶功能障礙的分子機制對于尋求更為有效的治療方法具有十分重要的意義。
[Abstract]:Alcohol poisoning is an important factor in inducing dementia. Recent studies have shown that alcohol interference in adult hippocampal neurogenesis is closely related to the induction of dementia. Alcohol can affect the regulation of learning and memory function by inhibiting the development of adult hippocampal neonate neurons, including inducing and promoting neuroinflammatory response. Inhibition of neurotrophic factor expression and interference of neural stem cell proliferation and differentiation related signal pathway. At present, the treatment of alcoholic dementia patients is limited and the therapeutic effect is not good. Therefore, it is very important to clarify the molecular mechanism of alcohol induced learning and memory dysfunction in order to find more effective treatment.
【作者單位】： 江西省人民醫(yī)院臨床醫(yī)學研究所;江西省人民醫(yī)院病理科;
【基金】：國家自然科學基金課題(No.81060111) 江西省衛(wèi)生廳中醫(yī)藥科研基金重大課題(No.2013Z005)
【分類號】：R749.62
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本文編號：1886126