精神分裂癥患者工作記憶EEG功能網(wǎng)絡(luò)屬性分析
本文選題:工作記憶 + 精神分裂癥; 參考:《計算機工程與應(yīng)用》2017年12期
【摘要】:精神分裂癥與一些認知障礙如信息處理、工作記憶等聯(lián)系緊密,研究工作是記憶任務(wù)中精神分裂癥患者與正常人的多通道腦電在各個階段、各個頻段存在哪些顯著性差異,可為精神分裂癥的診斷提供依據(jù)。使用相位鎖值(Phase Locking Value,PLV)來量化任意兩個電極通道之間的相位同步性,構(gòu)建腦功能網(wǎng)絡(luò)的關(guān)聯(lián)矩陣,計算不同稀疏度下腦網(wǎng)絡(luò)的全局屬性以及局部屬性曲線下面積,在同一階段、同一頻段下對精神分裂癥患者和正常人得到的屬性值進行非參數(shù)檢驗,找出差異顯著的屬性及節(jié)點,將對應(yīng)值作為特征訓(xùn)練SVM分類器,進而將精神分裂癥患者和正常人分類。屬性分析結(jié)果表明,工作記憶任務(wù)中θ和α頻段發(fā)揮主要作用的腦區(qū)集中在右側(cè)額葉區(qū)和枕葉區(qū),γ頻段相關(guān)的腦區(qū)集中在頂葉區(qū);精神分裂癥患者額葉右側(cè)區(qū)域與枕葉區(qū)電極間θ、α波相關(guān)性低于正常人,而其頂葉區(qū)電極間γ波的相關(guān)性高于正常人。
[Abstract]:Schizophrenia is closely related to some cognitive disorders such as information processing and working memory. It can provide basis for diagnosis of schizophrenia. The phase synchronization between any two electrode channels is quantified by using phase locked phase Locking (PLV), and the correlation matrix of brain functional network is constructed. The global properties of brain network and the area under the local attribute curve are calculated under different sparsity, and the area under the curve is calculated at the same stage. In the same frequency band, the attribute values obtained by schizophrenic patients and normal people were tested by non-parametric test, and the distinct attributes and nodes were found out. The corresponding values were trained as the characteristics of SVM classifier, and then the schizophrenic patients and normal persons were classified. The results of attribute analysis showed that the brain regions in which 胃 and 偽 bands played a major role in working memory tasks were concentrated in the right frontal lobe and occipital lobe, and those related to 緯 frequency were concentrated in the parietal lobe. The correlation of 胃, 偽 wave between the right frontal lobe and occipital area in schizophrenic patients was lower than that in the normal subjects, but the correlation between the electrodes in the parietal lobe was higher than that in the normal controls.
【作者單位】: 太原理工大學(xué)計算機科學(xué)與技術(shù)學(xué)院計算機科學(xué)系;太原師范學(xué)院計算機系;北京回龍觀醫(yī)院精神醫(yī)學(xué)研究中心;
【基金】:國家自然科學(xué)基金(No.61472270)
【分類號】:R749.3;TP274
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