發(fā)布時間：2018-05-11 03:05

  本文選題：冠心病 + 抑郁癥　； 參考：《青島大學(xué)》2016年碩士論文

【摘要】：目的探討冠心病合并抑郁癥患者心率變異性的變化,來了解自主神經(jīng)功能的改變,指導(dǎo)臨床治療和評估預(yù)后。方法選取2014年12月至2015年12月間在我院住院的120名患者作為研究對象,其中,冠心病組40例,抑郁癥組40例和冠心病合并抑郁癥組40例。選取在我院進(jìn)行健康查體的40例健康成年人作為對照組。所有入選者在入院后均進(jìn)行動態(tài)心電圖檢查,采用動態(tài)心電圖來觀察心率變異性的的變化。分析心率變異性所用的時域指標(biāo)是SDNN、r MSSD與p NN50,以及頻域指標(biāo)低頻功率(LF)和高頻功率(HF)。結(jié)果與對照組比較,冠心病組、抑郁癥組和冠心病合并抑郁癥組的心率變異性的各項指標(biāo)均降低,且差異有統(tǒng)計學(xué)意義。合并抑郁癥的冠心病患者與單純冠心病和抑郁癥患者比較,時域指標(biāo)和頻域指標(biāo)中的多項參數(shù)降低的更明顯,且差異有統(tǒng)計學(xué)意義(p0.05)。結(jié)論冠心病患者和抑郁癥患者心率變異性均有不同程度的降低,這表明他們的自主神經(jīng)受損和功能紊亂。與單純冠心病和抑郁癥患者相比,冠心病合并抑郁癥患者心率變異性降低的更明顯,其自主神經(jīng)功能損傷更明顯,這表明抑郁癥的發(fā)生加重了患者的自主神經(jīng)損傷和功能紊亂,發(fā)生心血管事件的風(fēng)險更大。
[Abstract]:Objective to investigate the changes of heart rate variability (HRV) in patients with coronary heart disease (CHD) complicated with depression in order to understand the changes of autonomic nervous function and to guide the clinical treatment and evaluate the prognosis. Methods 120 patients in our hospital from December 2014 to December 2015 were selected as study subjects, including 40 patients with coronary heart disease, 40 patients with depression and 40 patients with coronary heart disease combined with depression. 40 healthy adults in our hospital were selected as control group. All patients were examined by ambulatory electrocardiogram (ECG) after admission, and the changes of heart rate variability (HRV) were observed by ambulatory electrocardiogram (DECG). The time domain indexes used to analyze heart rate variability are SDNNNr MSSD and pNN50, as well as low frequency power and high frequency power in frequency domain. Results compared with the control group, the indexes of heart rate variability in coronary heart disease group, depression group and coronary heart disease combined depression group were all decreased, and the difference was statistically significant. Compared with simple CHD and depression patients with depression, the time domain and frequency domain indexes of multiple parameters decreased more significantly, and the difference was statistically significant (p 0.05). Conclusion Heart rate variability in patients with coronary heart disease and depression is decreased to some extent, which indicates that their autonomic nervous system is damaged and dysfunction. Compared with patients with simple coronary heart disease and depression, heart rate variability and autonomic nerve dysfunction in patients with coronary heart disease and depression were significantly decreased, which indicated that the occurrence of depression aggravated the autonomic nerve damage and dysfunction. Cardiovascular events are at greater risk.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R541.4;R749.4
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本文編號：1872119