本文選題：認(rèn)知損傷 + 事件相關(guān)電位　； 參考：《中國人民解放軍軍醫(yī)進(jìn)修學(xué)院》2012年碩士論文

【摘要】：沖突處理及干擾控制能力是日常生活能力中不可分割的一部分，且隨年齡增長逐漸下降，特別是阿爾茨海默病(AD)和輕度認(rèn)知功能障礙（MCI）患者。本研究主要探討不同認(rèn)知功能障礙患者的沖突解決能力有無下降，干擾效應(yīng)出現(xiàn)的層面是否不同，ERPs相關(guān)參數(shù)改變能否反映額葉功能改變及能否作為早期診斷認(rèn)知功能下降的指標(biāo)等問題。本研究采用改良的EriksenFlanker視覺刺激范式，它是被廣泛用來研究沖突解決及干擾效應(yīng)的任務(wù)。16個正常受試者、14個MCI患者和7個AD患者參與本項研究。Flanker范式包括四種狀態(tài)：無干擾狀態(tài)（或），表示無干擾；中性狀態(tài)（++++或++++)，表示知覺層面沖突;匹配狀態(tài)(或)，表示無沖突;沖突狀態(tài)(或)，表示知覺及反應(yīng)層面均發(fā)生沖突。中性狀態(tài)與無干擾狀態(tài)的差異說明知覺層面存在flanker干擾效應(yīng)，而沖突狀態(tài)與中性狀態(tài)的差異說明存在反應(yīng)層面的flanker干擾效應(yīng)。要求受試者對中間的箭頭方向做出反應(yīng)，指向左則左手按鍵，指向右則右手按鍵，而忽略旁邊的箭頭或“+”，同時記錄32導(dǎo)腦電、正確率和反應(yīng)時。結(jié)果：（1）行為指標(biāo)：中性狀態(tài)與無干擾狀態(tài)相比較、沖突狀態(tài)與中性狀態(tài)相比較，三組受試者分別在中性狀態(tài)和沖突狀態(tài)下正確率下降、反應(yīng)時延長，即在行為學(xué)上三組在知覺層面和反應(yīng)層面均存在flanker干擾效應(yīng)，AD組在知覺層面、反應(yīng)層面與NC、MCI組比較具有更明顯的干擾效應(yīng)。MCI組干擾效應(yīng)較AD弱，但同NC無明顯統(tǒng)計學(xué)差異。（2）ERPs：相較于MCI和NC組，AD組N2和P300潛伏期延長，MCI組較NC組P300潛伏期延長，差異有統(tǒng)計學(xué)意義，，而N2潛伏期則無統(tǒng)計學(xué)差異。MCI、AD組較NC組P300波幅顯著下降，有統(tǒng)計學(xué)差異。進(jìn)一步分析，與NC相比，MCI在知覺層面表現(xiàn)更顯著的干擾效應(yīng)；AD較MCI表現(xiàn)更明顯的反應(yīng)層面干擾效應(yīng)。結(jié)論：1.隨著認(rèn)知功能下降，MCI和AD組沖突處理及干擾控制能力下降，表現(xiàn)為正確率下降和反應(yīng)時延長。2.在本刺激范式下，MCI和AD患者N2潛伏期延長，波幅降低，提示額葉沖突處理和干擾控制功能受到影響。且負(fù)向波N2在評價認(rèn)知功能障礙患者的沖突處理及干擾效應(yīng)方面可能較正向波P300更敏感。3.在本刺激范式下，MCI和AD患者P300潛伏期無明顯變化，僅波幅降低，提示P300反映前額葉沖突信息加工及干擾控制功能損害可能并不敏感。4.對干擾控制進(jìn)行分層提示，MCI在知覺層面較NC表現(xiàn)更明顯的干擾效應(yīng)，AD較MCI和NC表現(xiàn)更顯著的知覺和反應(yīng)層面干擾，并可能作為診斷MCI和AD的潛在性指標(biāo)。
[Abstract]:The ability of conflict management and interference control is an integral part of the ability of daily living, and decreases gradually with age, especially in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). This study was designed to investigate whether the ability of conflict resolution in patients with different cognitive impairment decreased. Whether the level of interference effect is different whether the changes of ERPs related parameters can reflect the change of frontal lobe function and whether it can be used as an index for early diagnosis of cognitive dysfunction. In this study, the modified Eriksen Flanker visual stimulation paradigm was used. It is widely used to study conflict resolution and interference effects. Sixteen normal subjects, 14 patients with MCI and 7 patients with AD participated in this study. A neutral state (or a neutral state, representing a conflict at the perceptual level; a matching state, representing no conflict; or a state of conflict, indicating a conflict at the perceptual and reaction levels). The difference between neutral state and non-interference state indicates that there is flanker interference effect at perceptual level, while the difference between conflict state and neutral state indicates that there is flanker interference effect at reactive level. The subjects were asked to react to the middle arrow, pointing to the left hand button and the right hand button, ignoring the arrow or "", and recording the 32 EEG, accuracy and response time. Results (1) Behavioral index: compared with non-interference state, conflict state and neutral state, the correct rate of the three groups decreased and the reaction time was prolonged in neutral state and conflict state, respectively. That is to say, in behavioral science, there were flanker interference effects at the perceptual level and response level in AD group, and the interference effect was more obvious in response level than that in AD group, and the interference effect in MCI group was weaker than that in AD group. But there was no significant difference with NC. The N _ 2 and P _ 300 latencies of AD group were longer than that of NC group, and the N _ 2 latency of MCI group was longer than that of NC group, while the N _ 2 latency of MCI group was not significantly different from that of NC group. The amplitude of P300 wave in MCII-AD group was significantly lower than that in NC group. There is a statistical difference. Further analysis, compared with NC, MCI showed more significant interference effect at perceptual level. AD showed more obvious response level interference effect than MCI. Conclusion 1. The ability of conflict processing and interference control in MCI and AD groups decreased with cognitive decline, which showed that the correct rate was decreased and the response time was prolonged. 2. The N _ 2 latency was prolonged and the amplitude was decreased in patients with MCI and AD under this stimulus paradigm, indicating that the frontal lobe conflict management and interference control function were affected. Negative wave N2 may be more sensitive than positive wave P300 in evaluating conflict management and interference effect in patients with cognitive impairment. The P300 latency of MCI and AD patients showed no significant change under this stimulus paradigm, but the amplitude decreased, suggesting that P300 may not be sensitive to the damage of prefrontal lobe conflict information processing and interference control function. The interference effect of AD on perceptual level is more obvious than that of NC, and AD is more obvious in perception and response level than in MCI and NC, and may be used as a potential index for diagnosis of MCI and AD.
【學(xué)位授予單位】：中國人民解放軍軍醫(yī)進(jìn)修學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.1

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相關(guān)期刊論文 前1條

1 李樂加;王建軍;;阿爾茨海默病患者聽覺感覺記憶缺陷的神經(jīng)電生理觀察分析[J];臨床神經(jīng)電生理學(xué)雜志;2006年04期

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