本文選題：分裂型人格障礙 + 睪酮�。� 參考：《大連醫(yī)科大學》2012年碩士論文

【摘要】：目的：探討男性青少年分裂型人格障礙人群與正常人群之間的睪酮水平差異。重點探討青春期睪酮水平在分裂型人格障礙形成中的作用,以及睪酮水平對分裂型人格障礙各臨床癥狀維度的影響。 方法：應用MMPI-566（明尼蘇達多項人格測試）對某大學2011年3500名入學男性新生進行普查，，符合MMPI的4,6,8編碼者，SC尺度分值大于70分，且F值在65~79分值范圍內者被作為分裂型人格特征陽性者，再經(jīng)2名精神科主治醫(yī)師使用DSM-IV分裂型人格障礙結構性訪談問卷篩選出50名分裂型人格特征陽性者作為實驗組。隨機選取MMPI各個臨床尺度在正常范圍內的學生50名為健康對照組。采用一般問卷、分裂型人格問卷(Schizotypal personality questionnaire, SPQ)對兩組人群進行調查；為了觀測胎兒期間暴露于睪酮水平,2D:4D比值被測量；為了進一步的觀察是否母孕季節(jié)是女性高睪酮分泌期,所有被試的母親懷孕季節(jié)被調查；采用電化學發(fā)光法測定分析血清游離睪酮水平。 結果：①分裂型人格障礙組（n=50）與正常對照組（n=50）的睪酮水平在兩組間差異顯著（t=2.319,p=0.023）；②母親懷孕季節(jié)分布在分裂型人格障礙組與正常對照組之間差異不顯著（2=1.250,p=0.741）；③分裂型人格障礙組左手2D:4D比值與正常對照組之間差異不顯著（t=0.259, p=0.796）；④分裂型人格障礙組中睪酮水平與SPQ怪異信念呈顯著正相關（r=0.382,p=0.011）；⑤分裂型人格障礙組內高低睪酮組間SPQ因子分比較，怪異信念得分高睪酮水平組顯著高于低睪酮水平組（t=2.509,p=0.020）；⑥回歸分析結果發(fā)現(xiàn)，睪酮水平是分裂型人格障礙怪異信念及精神分裂質的危險因素。 結論：①首次明確分裂癥易感人格群體的分裂型人格障礙組睪酮水平顯著高于正常對照組；②母親懷孕季節(jié)分布在分裂型人格障礙組與正常對照組之間差別不顯著；2D:4D比值也未提示分裂型人格障礙組較正常對照組在胎兒時期過多暴露于睪酮。所以我們認為青春期睪酮水平急劇增加對分裂型人格障礙的形成才是至關重要的。③睪酮是影響怪異信念的首要因素，并且怪異信念可能是精神分裂癥或分裂型人格障礙的早期行為特征。青春期睪酮水平偏高很可能作為分裂癥早期癥狀的生物學標志。
[Abstract]:Objective: to explore the difference of testosterone levels between male adolescents with split personality disorder and normal subjects. To explore the role of adolescent testosterone level in the formation of split personality disorder and the effect of testosterone level on the clinical symptom dimensions of split personality disorder. Methods: a total of 3500 male freshmen enrolled in a university in 2011 were surveyed by MMPI-566 (Minnesota Personality Test). The SC-scale scores of the 4MMPI-566 encoders in accordance with MMPI were greater than 70. The F value in the range of 650.79 was regarded as positive for split personality, and 50 split personality traits were selected as experimental group by two psychiatrists using DSM-IV split personality disorder structured interview questionnaire. 50 students with normal clinical scale of MMPI were randomly selected as healthy control group. A general questionnaire and a split personality questionnaire (Schizotypal personality questionnaire, SPQ) were used to investigate the two groups; to measure the ratio of 2D: 4D to testosterone level during fetal exposure; and to further investigate whether the maternal pregnancy season was a period of high testosterone secretion in women. All mothers were investigated during pregnancy and serum free testosterone levels were determined by electroluminescence assay. Results there was significant difference between the two groups in the testosterone level between the two groups. There was no significant difference between the two groups in the pregnant season between the two groups. There was no significant difference between the split personality disorder group and the normal control group. There was no significant difference between the two groups in the level of testosterone in the two groups, and the difference was not significant in the split personality disorder group and the normal control group. There was no significant difference in the level of testosterone between the two groups. There was no significant difference between the left hand 2D:4D ratio of the personality disorder group and the normal control group. There was no significant difference between the left hand 2D:4D ratio and the normal control group. There was a significant positive correlation between testosterone level and SPQ weird belief in the split personality disorder group. There was a significant positive correlation between the high and low testosterone factor scores in the split personality disorder group and the SPQ factor score in the high and low testosterone group. The results of regression analysis showed that the level of testosterone was a risk factor of schizophrenia personality disorder. Conclusion the testosterone level in the split personality disorder group was significantly higher than that in the normal control group. 2There was no significant difference of 2D: 4D ratio between the split personality disorder group and the normal control group during pregnancy season, nor did it indicate that the split personality disorder group was more exposed to testosterone in the fetal period than the normal control group. So we think that a sharp rise in adolescent testosterone is the most important factor in the formation of split personality disorders, and that testosterone is the primary factor that affects weird beliefs. And weird beliefs may be an early behavioral feature of schizophrenia or schizophrenic personality disorder. The high level of testosterone in adolescence may be used as a biological marker of early symptoms of schizophrenia.
【學位授予單位】：大連醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R749.94

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