本文選題：原發(fā)性高血壓 + 抑郁障礙　； 參考：《新疆醫(yī)科大學(xué)》2013年碩士論文

【摘要】：目的：探究原發(fā)性高血壓（EH）患者合并抑郁障礙與血漿同型半胱氨酸水平（Hcy）之間的相關(guān)性。方法：收集2011年8月-2012年6月在我院干部病房?jī)?nèi)科住院治療的原發(fā)性高血壓患者163例，高血壓診斷符合2005年高血壓診斷標(biāo)準(zhǔn)。所有入選患者均通過Zung抑郁自評(píng)量表（SDS）和綜合醫(yī)院焦慮抑郁量表抑郁分表篩查患者抑郁障礙，用循環(huán)酶法測(cè)定血漿同型半胱氨酸（Hcy）水平。結(jié)果：本研究中共有69例（42.3%）患者合并抑郁障礙；有31例患者發(fā)生高同型半胱氨酸血癥（HHcy）；將163例患者按是否合并抑郁障礙分為抑郁組和非抑郁組，兩組患者在年齡、體質(zhì)指數(shù)、高血壓病程、高血壓分級(jí)、冠心病合并率間差異均無統(tǒng)計(jì)學(xué)意義（P＞0.05）；在性別、Hcy水平及高Hcy血癥發(fā)生人數(shù)間差異有統(tǒng)計(jì)學(xué)意義（P＜0.05），其中女性高血壓患者抑郁障礙的發(fā)生率高于男性（53.8%，36.9%，x~2=4.417，P=0.031），合并抑郁障礙組的血漿Hcy水平高于未合并抑郁組者［(12.89±9.17)μmol/L和（10.44±8.02）μmol/L，t=1.774，P=0.039］，HHcy發(fā)生率也明顯高于未合并抑郁組（26.1%，13.8%，x~2=3.882，P=0.039）。將163例患者按血壓水平分為3組，不同血壓分級(jí)間患者血漿Hcy水平差異無統(tǒng)計(jì)學(xué)意義（P＞0.05），不同血壓分級(jí)間患者SDS評(píng)分差異有統(tǒng)計(jì)學(xué)意義(P＜0.05)。結(jié)論：原發(fā)性高血壓患者有較高的抑郁障礙發(fā)生率，且存在性別差異，，女性高于男性；合并抑郁障礙的高血壓患者血漿中Hcy水平及HHcy發(fā)生率均增加。
[Abstract]:Objective: To investigate the correlation between depressive disorder and plasma homocysteine level (Hcy) in patients with essential hypertension (EH). Methods: 163 patients with essential hypertension hospitalized in the medical department of our hospital in June August 2011 were collected. The diagnosis of hypertension was in accordance with the diagnostic criteria of hypertension in 2005. All the patients were selected. The Zung depression self rating scale (SDS) and the general hospital anxiety and depression scale depression scale were used to screen the depressive disorder and the plasma homocysteine (Hcy) levels were measured by circulating enzyme. Results: 69 cases (42.3%) patients with depressive disorder were combined with depressive disorder; 31 patients with hyperhomocysteinemia (HHcy); and 163 patients. There were no significant differences between the two groups in age, body mass index, hypertension course, hypertension classification, and the rate of coronary heart disease (P > 0.05), and there were significant differences in the gender, Hcy level and high Hcy number (P < 0.05), among which women were hypertensive patients. The incidence of depressive disorder was higher than that of men (53.8%, 36.9%, x~2=4.417, P=0.031). The level of plasma Hcy in the group with depressive disorder was higher than that in the non depression group [(12.89 + 9.17) mu mol/L and (10.44 + 8.02) mu mol/L, t=1.774, P=0.039], and the incidence of HHcy was significantly higher than that in the uncombined depression group (26.1%, 13.8%, x~2=3.882, P=0.039). The blood pressure level was divided into 3 groups. There was no significant difference in plasma Hcy level in patients with different blood pressure grades (P > 0.05). The difference of SDS score between different blood pressure classification patients was statistically significant (P < 0.05). Conclusion: the incidence of depressive disorder in patients with primary hypertension was higher, and there was gender difference, women were higher than men, and depression was associated with depressive disorder. The level of plasma Hcy and HHcy increased in patients with hypertension.

【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R544.11;R749.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 喬娟;趙后鋒;朱相華;劉艷;耿德勤;;抑郁癥患者血清同型半胱氨酸水平的研究[J];中國(guó)實(shí)用神經(jīng)疾病雜志;2011年01期

2 陳鵬宇;胡澤卿;;5-羥色胺能系統(tǒng)在抑郁癥中的研究進(jìn)展[J];神經(jīng)疾病與精神衛(wèi)生;2008年04期

3 張保敏;高穎;郭藝芳;;高血壓與抑郁癥[J];臨床薈萃;2007年17期

4 畢婧瑋;梁燕儀;蔡文瑋;馬紹駿;朱健;;心血管疾病患者抑郁焦慮的研究現(xiàn)狀[J];中國(guó)臨床保健雜志;2011年03期

5 印小榮,段寶祥,何曉虹,張幼祥,李蓬;血壓正常高值對(duì)動(dòng)脈內(nèi)膜中膜厚度(IMT)的影響[J];南京醫(yī)科大學(xué)學(xué)報(bào)(自然科學(xué)版);2005年11期

6 任延平;黃若文;高路;李懷琳;;老年高血壓患者合并抑郁狀態(tài)與性別的相關(guān)性研究[J];中國(guó)全科醫(yī)學(xué);2010年21期

7 王善信;李浩福;王斌;殷愛華;王e

本文編號(hào)：1824001