本文選題：精神分裂癥 + 靜息態(tài)　； 參考：《南京醫(yī)科大學(xué)》2013年碩士論文

【摘要】：目的：本研究利用功能磁共振成像(functional magnetic resonance imaging, fMRI)技術(shù)，旨在從局部一致性（regional homogeneity, ReHo）和低頻振幅（amplitudeof low frequency fluctuation, ALFF）角度，探討首次發(fā)病且未用藥的偏執(zhí)型精神分裂癥(schizophrenia, SCH)患者靜息狀態(tài)下是否存在腦局部自發(fā)神經(jīng)元活動(dòng)異常以及異常腦區(qū)的定位。 方法：采用美國(guó)精神疾病診斷與統(tǒng)計(jì)手冊(cè)第4版（Diagnostic and Statistical Manualof Mental Disorders, Fourth edition, DSM-IV-TR）診斷入組精神分裂癥患者；采用3.0T功能磁共振成像系統(tǒng)，對(duì)20例首發(fā)未用藥的偏執(zhí)型精神分裂癥患者及同期入組的20名性別、年齡和受教育年相匹配的健康志愿者進(jìn)行靜息狀態(tài)下全腦的fMRI檢查；在進(jìn)行磁共振掃描當(dāng)天評(píng)估患者的陽(yáng)性與陰性癥狀量表（positive andnegative symptom scale, PANSS）分�；贛atlab7.8軟件平臺(tái)，采用SPM8和REST軟件對(duì)所獲取的影像數(shù)據(jù)進(jìn)行處理分析，計(jì)算出各受試者的ReHo值和ALFF值，采用獨(dú)立樣本t檢驗(yàn)比較精神分裂癥組相對(duì)于健康對(duì)照組ReHo值和ALFF值增高及降低的腦區(qū)，，當(dāng)P0.005以及區(qū)域的體積不小于324mm3時(shí)，認(rèn)為差異有統(tǒng)計(jì)學(xué)意義(Alphasim多重比較校正后P0.05)。 結(jié)果：1，相比對(duì)照組，患者組靜息態(tài)腦BOLD信號(hào)的ReHo值增高的腦區(qū)有右側(cè)額上回和雙側(cè)楔前葉；ReHo值降低的腦區(qū)為左側(cè)胼胝體。 2，相比對(duì)照組，患者組靜息態(tài)腦BOLD信號(hào)的ALFF值增高的腦區(qū)有右側(cè)額中回、右側(cè)楔前葉、右側(cè)小腦后葉；ALFF值降低的腦區(qū)為右側(cè)邊緣葉。 結(jié)論：1，首發(fā)未用藥偏執(zhí)型精神分裂癥患者存在靜息狀態(tài)下腦功能活動(dòng)的fMRI信號(hào)異常。 2，偏執(zhí)型精神分裂癥患者右側(cè)額上回、雙側(cè)楔前葉、左側(cè)胼胝體ReHo異常可能與其神經(jīng)自發(fā)活動(dòng)的協(xié)調(diào)機(jī)制異常相關(guān)。 3，偏執(zhí)型精神分裂癥患者右側(cè)額中回、楔前葉、小腦后葉、邊緣葉ALFF異常提示其相應(yīng)腦區(qū)的自發(fā)神經(jīng)元活動(dòng)水平異常。 4，ReHo和ALFF兩種方法的結(jié)合，在一定程度上反映了相關(guān)腦區(qū)的功能活動(dòng)異常，有助于更好地認(rèn)識(shí)和理解精神分裂癥的病理生理機(jī)制和腦網(wǎng)絡(luò)功能活動(dòng)特征。
[Abstract]:Objective: to investigate the regional homogeneity (ReHoe) and low frequency amplitude of low frequency imaging (ALFFF) in functional magnetic resonance imaging (fMRI). To investigate whether the spontaneous neuronal activity in the brain is abnormal and the location of the abnormal brain area in the resting state of the patients with first-onset and untreated paranoid schizophrenia (Sch). Methods: the Diagnostic and Statistical Manualof Mental Disorders, Fourth edition, DSM-IV-TR) were used to diagnose the patients with schizophrenia, and the 3.0T functional magnetic resonance imaging system was used to diagnose the patients with schizophrenia. FMRI examination of the whole brain was performed in 20 patients with first-episode untreated paranoid schizophrenia and 20 healthy volunteers who were matched in sex, age and years of education in the same period. Positive andnegative symptom scale (PANSS) was evaluated on the day of MRI. Based on the Matlab7.8 software platform, SPM8 and REST software are used to process and analyze the acquired image data, and the ReHo and ALFF values of each subject are calculated. An independent t-test was used to compare the brain regions of schizophrenic patients with higher and lower ReHo and ALFF values compared with those of healthy controls. When P0.005 and the volume of the regions were not less than 324mm3, the difference was statistically significant after the multiple comparison of Alphasim was corrected (P0.05). Results compared with the control group, the left corpus callosum was found in the right superior frontal gyrus and bilateral precuneial lobe where the ReHo value of BOLD signal was increased in the rest brain of the patient group compared with the control group. 2Compared with the control group, the right middle frontal gyrus, the right anterior cuneate lobe and the right posterior cerebellar lobe decreased the ALFF value of the resting brain in the right marginal lobe. Conclusion the fMRI signal of brain function was abnormal in patients with first episode nonmedication paranoid schizophrenia under resting state. 2. The abnormality of ReHo in the right superior frontal gyrus, bilateral anterior cuneate lobe and left corpus callosum in paranoid schizophrenic patients may be related to the abnormal coordination mechanism of nerve spontaneous activity. 3. The abnormal ALFF in the right middle frontal gyrus, anterior cuneiform lobe, posterior cerebellar lobe and marginal lobe of paranoid schizophrenia suggests the abnormal level of spontaneous neuron activity in the corresponding brain region. 4the combination of ReHo and ALFF may reflect the abnormal function of the related brain area to some extent, and help to better understand the pathophysiological mechanism and the functional characteristics of brain network in schizophrenia.
【學(xué)位授予單位】：南京醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R749.3;R445.2

【參考文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 王繼才;難治性精神分裂癥患者及其親屬的臨床特征和腦功能及腦結(jié)構(gòu)的磁共振研究[D];中南大學(xué);2009年

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