本文選題：輕度認(rèn)知障礙　切入點(diǎn)：Stroop效應(yīng)　出處：《中國老年學(xué)雜志》2017年15期

【摘要】：目的探索老年輕度認(rèn)知障礙(MCI)患者客觀量化的臨床篩檢指標(biāo),簡(jiǎn)化測(cè)評(píng)手段,減少主觀評(píng)判誤差。方法采用1∶1病例對(duì)照研究方法確定MCI組和對(duì)照組各46例,應(yīng)用Stroop色字干擾測(cè)驗(yàn)評(píng)定其認(rèn)知功能缺損程度。結(jié)果 MCI與對(duì)照組Stroop效應(yīng)耗時(shí)A、B、C、(C-B)/A和正確數(shù)A、B、C、(B-C)/A均有統(tǒng)計(jì)學(xué)差異(P0.05或P0.01)。Stroop效應(yīng)耗時(shí)A、B、(C-B)/A與Mo CA總分、視空間、注意力、記憶力(耗時(shí)A除外)、抽象思維存在相關(guān)性,耗時(shí)C與Mo CA總分、注意力、記憶力存在相關(guān)性(P0.05或P0.01);正確數(shù)A與注意力存在相關(guān)性,正確數(shù)B與Mo CA總分、注意力、記憶力、命名存在相關(guān)性,正確數(shù)C與Mo CA總分、注意力存在相關(guān)性,正確數(shù)(B-C)/A與Mo CA總分、視空間、注意力、記憶力存在相關(guān)性(P0.05或P0.01)。Stroop效應(yīng)受試者工作特征(ROC)曲線分析,耗時(shí)增加率(C-B)/A38.5%時(shí)篩檢MCI的靈敏度71.7%、特異度71.6%、約登指數(shù)43.3%;正確數(shù)遞減率(B-C)/A4.2%時(shí),靈敏度73.9%、特異度78.3%、約登指數(shù)52.2%;耗時(shí)增加率38.5%或正確數(shù)遞減率4.2%并聯(lián)篩檢MCI的靈敏度91.3%、特異度93.5%、約登指數(shù)84.8%。結(jié)論 MCI患者存在多重領(lǐng)域認(rèn)知功能損害,主觀測(cè)評(píng)難度較大,Stroop效應(yīng)診斷MCI具有較好的靈敏度和特異度,測(cè)驗(yàn)簡(jiǎn)單快捷,較為適合作為老年人群體檢中篩查MCI的檢測(cè)工具。
[Abstract]:Objective to explore the objective and quantitative clinical screening indexes of elderly patients with mild cognitive impairment (MCI), simplify the evaluation method and reduce the subjective judgment error. Methods the 1:1 case-control study was used to determine 46 cases in MCI group and 46 cases in control group. Results there were significant differences in the duration of Stroop effect between MCI and the control group (P 0.05) or P0.01).Stroop effect (P 0.05) or P0.01).Stroop effect (P 0.05), visual space, attention, total CA, visual space, attention, and so on, and the results showed that there were significant differences in the duration of Stroop effect between MCI and the control group (P 0.05), and the effect of P0.01).Stroop on C-B / C / A / A ratio A / A was significantly different from that of the control group (P < 0.05). Memory (except for time-consuming A, there was correlation between abstract thinking, time consuming C and Mo CA total score, attention, memory correlation P 0.05 or P 0.01), correct number A was correlated with attention, correct number B and Mo CA total score, attention, memory, There was correlation between naming, correct number C and total score of Mo CA, total score of attention, total score of B-CU / A and Mo CA, correlation of visual space, attention and memory (P0.05 or P0.01).Stroop effect) curve analysis. The sensitivity of screening MCI was 71.7%, the specificity was 71.6, the Yorden index was 43.3%, and the correct decline rate was 4.2% when C-BN / A38.5%. Sensitivity 73.9%, specificity 78.3%, Yorden index 52.2%, time consuming increase rate 38.5% or correct number decline rate 4.2%, sensitivity 91.3%, specificity 93.5%, and Yorden index 84.8. Conclusion there are multiple domain cognitive impairment in patients with MCI, and the sensitivity is 91.3%, the specificity is 93.5%, and the Jorden index is 84.8%, and the sensitivity is 91.3%, the specificity is 93.5%, and the Yorden index is 84.8%. The subjective evaluation is more difficult than the Stroop effect in the diagnosis of MCI. It has good sensitivity and specificity, and the test is simple and quick. It is suitable for the detection of MCI in the physical examination of the elderly population.
【作者單位】： 嘉興學(xué)院醫(yī)學(xué)院;
【基金】：2015級(jí)國家級(jí)大學(xué)生創(chuàng)新項(xiàng)目(No.201510354021) 嘉興市科技計(jì)劃項(xiàng)目(No.2012AY1075-1)
【分類號(hào)】：R749.1

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