本文選題：雙相情感障礙　切入點：躁狂/輕躁狂發(fā)作　出處：《重慶醫(yī)科大學(xué)學(xué)報》2017年05期 　論文類型：期刊論文

【摘要】：目的:探討雙相情感障礙躁狂/輕躁狂發(fā)作、抑郁發(fā)作與混合發(fā)作患者甲狀腺功能。方法:采用化學(xué)發(fā)光免疫分析法測定來自重慶醫(yī)科大學(xué)附屬大學(xué)城醫(yī)院心理衛(wèi)生中心雙相情感障礙躁狂/輕躁狂發(fā)作患者(62例)、抑郁發(fā)作患者(71例)與混合發(fā)作患者(26例)以及該院體檢中心203名性別、年齡匹配的正常對照(對照組)血清促甲狀腺激素(thyroid stimulating hormone,TSH)、游離三碘甲腺原氨酸(free triiodothyronine,FT3)、游離甲狀腺素(free thyroxine,FT4)、三碘甲狀腺原氨酸(triiodothyronine,T3)及甲狀腺素(thyroxine,T4)水平。結(jié)果:雙相情感障礙躁狂/輕躁狂發(fā)作者TSH水平低于[1.650(0.803,2.400)vs.2.100(1.610,3.030),P0.01]、FT4水平高于[18.420(15.530,20.060)vs.16.600(14.890,17.640),P0.01]對照組;抑郁發(fā)作者T3、T4水平[1.580(1.180,1.890)vs.1.770(1.610,1.990),84.170(62.540,97.940)vs.95.54(86.020,109.500),P0.01]均低于對照組;混合發(fā)作者T3水平[1.440(1.273,1.783)vs.1.770(1.610,1.990),P0.01]低于對照組。與躁狂/輕躁狂發(fā)作者相比,抑郁發(fā)作者T4、FT4水平均更低[96.39(76.768,123.040)vs.84.170(62.540,97.940),18.420(15.530,20.060)vs.16.520(13.670,19.080),P0.05]。有雙相家族史患者血漿中TSH水平高于無家族史雙相患者(2.735±2.240 vs.1.892±1.276,P=0.039);女性雙相患者T3、T4水平均低于正常女性對照(1.362±0.674 vs.1.769±0.290,78.407±39.180 vs.96.396±22.635,P=0.000)。結(jié)論:雙相情感障礙抑郁發(fā)作、躁狂發(fā)作、混合發(fā)作時甲狀腺功能均有異常,但三者的改變各不相同。
[Abstract]:Objective: to investigate bipolar disorder mania / hypomania. Thyroid function in patients with depression attack and mixed attack. Methods: the bipolar affective disorder patients with mania / hypomania were measured by chemiluminescence immunoassay from the mental health center of the university hospital affiliated to Chongqing medical university. There were 62 patients with depressive attack, 71 patients with depression and 26 patients with mixed attack. Age matched normal control group (control group), the levels of thyroid hormone thyroid stimulating hormonet, free triiodothyronine free triiodothyronine FT3, free thyroxine free thyroxine FT4, triiodothyronine triiodothyronine T3 and thyroxine thyroxine T4). The level of TSH in patients with manic / hypomania attack was lower than that in control group [1.650 鹵0.803U 2.400 vs.2.100 + 1.61010 / 3.030U P0.01] FT4 was higher than that in control group [18.420 鹵15.530 20.060 vs.16.600 ~ 14.890 鹵17.640U P0.01]. The levels of T3OT4 in patients with depression attack [1.580 / 1.180 / 1.890 / vs.1.7701.6 / 1010 / 1.990 / 84.170 / 62.54097.940 / vs.95.5440 / 86.020109.500] were lower than those in the control group, while the T3 level in the patients with mixed attack [1.4401.273n 1.783vs.1.7701.161.61010 / 1.990P0.01] was lower than that in the patients with mania / hypomania (P 0.01), and compared with that in patients with mania / hypomania, the level of T 3 in patients with depression attack was significantly lower than that in patients with hypomania / hypomania (P 0.01). The levels of T4FT-4 in patients with bipolar disorder were significantly lower than those in patients with bipolar family history (96.39) 76.7683.040 / vs.84.170 (62.540 / 97.940) and 18.42015.530 / 20.060vs.16.52013.670 / 19.080V respectively. Conclusion: the level of TSH in patients with bipolar family history is higher than that in patients with bipolar disorder without family history (2.735 鹵2.240 vs.1.892 鹵1.276P0.039), and the levels of T3T4 in bipolar patients are all lower than those in normal female controls (1.362 鹵0.674 vs.1.769 鹵0.2978.407 鹵39.180 vs.96.396 鹵22.635P0. 05). Conclusion: the level of T3 T4 in patients with bipolar family history is 2.735 鹵2.240 鹵1.276P0.0390.The levels of T3 T4 in patients with bipolar disorder are all lower than those in normal female controls (1.362 鹵0.674 vs.1.769 鹵0.2978.407 鹵39.180 vs.96.396 鹵22.635P0. 05). There were abnormal thyroid function in manic attack and mixed attack, but the changes were different among the three groups.
【作者單位】： 重慶醫(yī)科大學(xué)附屬大學(xué)城醫(yī)院心理衛(wèi)生中心;重慶醫(yī)科大學(xué)附屬第一醫(yī)院心理衛(wèi)生中心;
【分類號】：R749.4

【參考文獻】

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本文編號：1645040