本文選題：血管性認(rèn)知障礙　切入點(diǎn)：NINJ2基因　出處：《青島大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討神經(jīng)損傷誘導(dǎo)蛋白(NINJ2)基因rs11833579、rs12425791位點(diǎn)多態(tài)性與血管性認(rèn)知功能障礙(Vascular cognitive impairment,VCI)的相關(guān)性。方法:采用聚合酶鏈反應(yīng)-限制性片段長度多態(tài)性技術(shù)(PCR-RFLP)對112例VCI患者(VCI組)、108例腦梗死后無認(rèn)知功能障礙患者(NCI組)及113例健康者(對照組)的NINJ2 rs11833579、rs12425791位點(diǎn)進(jìn)行基因型檢測,比較基因型和等位基因頻率在各組是否存在差異并進(jìn)行關(guān)聯(lián)性分析。結(jié)果:(1)rs11833579位點(diǎn):三組間基因型、等位基因分布差異均無統(tǒng)計(jì)學(xué)意義(x2=1.942,P0.05;X2=1.343,P0.05);多項(xiàng)logistic回歸校正危險(xiǎn)因素后,VCI組及NCI組AA+AG基因型對患病風(fēng)險(xiǎn)無明顯影響。(2)rs12425791位點(diǎn):三組基因型、等位基因分布差異有統(tǒng)計(jì)學(xué)意義(X2=27.036,P0.05;X2=19.816,P0.05);多項(xiàng)logistic回歸校正危險(xiǎn)因素后,VCI組及NCI組AA+AG基因型與VCI、腦梗死的發(fā)病呈相關(guān)關(guān)系(OR=1.785,95%CI 1.008~3.159,P0.05;OR=1.864,95%CI1.061~3.274,P0.05)。(3)三組間性別、年齡、吸煙、血脂TG、TC水平比較,差異沒有統(tǒng)計(jì)學(xué)意義(P0.05)。VCI組高血壓病和糖尿病的發(fā)病率顯著高于對照組(P0.05),血脂高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平和對照組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:1.NINJ2基因rs12425791位點(diǎn)的多態(tài)性與VCI有相關(guān)性,該位點(diǎn)對VCI的影響可能與腦損傷修復(fù)有關(guān)。2.本研究VCI組與對照組相比,高血壓病和糖尿病的發(fā)病率、血脂LDL水平和HDL水平差異有統(tǒng)計(jì)學(xué)意義,提示高血壓、糖尿病、高LDL水平可能是VCI的危險(xiǎn)因素。
[Abstract]:Objective: to investigate the association between rs11833579 (rs12425791) polymorphism and Vascular cognitive impairment (VCII) of nerve injury inducible protein nin J22.Methods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used in 112 patients with VCI. The genotypes of NINJ2 rs11833579 (rs12425791) were detected in 108 patients with no cognitive impairment after cerebral infarction and 113 healthy subjects (control group). The genotypes and allelic frequencies were compared among the three groups and the correlation analysis was carried out. Results: 1: 1 rs11833579: genotypes among the three groups, There was no significant difference in allelic distribution between VCI group and NCI group (P 0.05 rs12425791), there was no significant difference in allelic distribution between VCI group and NCI group, and there was no significant difference in alleles distribution between VCI group and NCI group (P 0.05 rs12425791 locus: three genotypes), and there was no significant difference in AA AG genotype between VCI group and NCI group after adjustment of risk factors by multiple logistic regression. There was a significant difference in allele distribution among the three groups: sex, age, smoking, blood lipids and TGTC levels in VCI group and NCI group after adjustment for risk factors. The incidence of cerebral infarction was related to the incidence of CI 1.785Cl 1.78595 CI 1.0083.159P0.05OR1.86495 CI1.0613.274P0.05.3The three groups were compared with each other in sex, age, smoking, and TGTC levels. There was no significant difference in the incidence of hypertension and diabetes in the group of P0.05. VCI and compared with that in the control group. The levels of HDLN and LDL were significantly higher in the VCI group than in the control group. Conclusion: 1. The polymorphism of the rs12425791 locus of NINJ2 gene is associated with VCI, and the effect of this locus on VCI may be related to the repair of brain injury. 2. The incidence of hypertension and diabetes mellitus in the VCI group was higher than that in the control group. There were significant differences between LDL and HDL levels, suggesting that hypertension, diabetes and high LDL levels might be risk factors for VCI.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R749.13

【相似文獻(xiàn)】

相關(guān)期刊論文 前1條

1 陳廓;肖占森;侯淑琴;趙潤田;劉岳峰;竇會(huì)東;李廣平;陶曉明;李峰;周文郁;邱長春;;NINJ2基因多態(tài)性與房山地區(qū)漢族腦卒中易感強(qiáng)相關(guān)[J];北京大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2010年05期

相關(guān)會(huì)議論文 前1條

1 王麗;潘旭東;王源;王琨;馬愛軍;徐翔;周潤澤;趙國梅;;NINJ2基因多態(tài)性與大動(dòng)脈粥樣硬化型腦卒中的相關(guān)性及血管床選擇性的初步探討[A];山東省2013年神經(jīng)內(nèi)科學(xué)學(xué)術(shù)會(huì)議暨中國神經(jīng)免疫大會(huì)2013論文匯編[C];2013年

相關(guān)碩士學(xué)位論文 前1條

1 賈少坤;NINJ2基因多態(tài)性與血管性認(rèn)知功能障礙的相關(guān)性研究[D];青島大學(xué);2015年

，

本文編號(hào)：1613310