發(fā)布時間：2018-03-08 04:20

  本文選題：海馬益智散　切入點：腦卒中后認知功能障礙　出處：《新疆醫(yī)科大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:評價海馬益智散治療不同程度的腦卒中后認知功能障礙(Post stroke cognitive impairment,PSCI)患者的臨床療效,為海馬益智散的臨床應(yīng)用提供依據(jù)。方法:選取2014—2015年烏魯木齊市中醫(yī)醫(yī)院收治的PSCI患者180例,由患者本人或其家屬簽署知情同意書,志愿受試。(知情同意書詳情見附表1)。通過畫鐘試驗(CDT)作出癡呆程度(0-1分為重度,2分為中度,3分為輕度)的判定,分為輕度、中度、重度(A組、B組、C組),遵循隨機對照原則,采用隨機數(shù)字表法各組再分為實驗組(A1組、B1組、C1組)與對照組(A2組、B2組、C2組),2組均給予常規(guī)西藥治療,治療組在此基礎(chǔ)上加服海馬益智散。治療3個月后觀察2組蒙特利爾認知評估表(Montreal cognitive assessment,Mo CA)和日常生活能力量表(Activities of daily living,ADL)、簡易精神狀態(tài)檢查表(Mini-Mental State Examination,MMSE)、中醫(yī)癥狀積分值評分變化。結(jié)果:在兩組間患者年齡、性別等相關(guān)因素經(jīng)統(tǒng)計學(xué)處理,具有可比性的前提下,輕中度患者治療后MMSE、Mo CA、ADL及中醫(yī)證候積分均有所改善,與治療前比較(P0.05)差異均有顯著性意義,重度患者治療前后差異無顯著意義,治療后各治療組和對照組MMSE、Mo CA、ADL分值組間對比(P0.05),差異均無顯著性意義,中醫(yī)證候積分值組間對比(P0.05)差異有顯著性意義。結(jié)論:海馬益智散治療輕中度PSCI患者的臨床療效確切,可明顯改善輕中度PSCI患者的認知能力、日常生活能力及相關(guān)中醫(yī)癥候,在中醫(yī)癥候的療效改善方面,海馬益智散較尼莫地平片顯效。能提高患者的生活質(zhì)量,有利于輕中度PSCl患者的轉(zhuǎn)歸預(yù)后向積極的方向發(fā)展,值得推廣應(yīng)用。
[Abstract]:Objective: to evaluate the clinical efficacy of Hippocampal Yizhi Powder (YZS) in the treatment of post stroke cognitive impairment (PSCI) patients with different degree of cognitive dysfunction after stroke. Methods: 180 PSCI patients treated in Urumqi traditional Chinese Medicine Hospital from 2014-2015 were selected and informed consent was signed by the patients themselves or their families. Voluntary subjects. (see schedule 1 for details of informed consent forms. Using bell drawing test CDT) to determine the degree of dementia from 0-1 to 2 to moderate to 3 to mild), divided into mild, moderate and severe group A, B, C, followed the principle of randomized control. Each group was subdivided into experimental group (group A 1) and group B 1 (group C 1) and control group (group A 2) and group B 2 (group C 2) were treated with routine western medicine. After 3 months of treatment, the two groups were observed the activities of daily activities of daily activities and activities of daily activities, mini-mental State examination, MMSE, and TCM symptom score after 3 months of treatment, the two groups were treated with Montreal cognitive assessment and CAA) and the activity of daily activities of activities of daily living scale (ADL), the mini-mental state examination form (Mini-Mental State examination), and the symptom score of traditional Chinese medicine (TCM) were observed after 3 months of treatment. Results: the age of the patients between the two groups, On the basis of statistical analysis and comparability of sex and other related factors, MMSE Mo CAG ADL and TCM syndromes scores were improved after treatment in mild and moderate patients, and there were significant differences compared with those before treatment (P 0.05). There was no significant difference before and after treatment in severe patients. There was no significant difference in the scores of MMSE Mo CAG ADL between the treatment group and the control group before and after treatment (P 0.05). Conclusion: HYZS is effective in the treatment of mild and moderate PSCI patients, and can obviously improve the cognitive ability, daily living ability and related TCM symptoms in patients with mild and moderate PSCI. In the aspect of improving the curative effect of TCM symptoms, Yizhi Powder of hippocampus is more effective than nimodipine tablet, which can improve the quality of life of patients, and is beneficial to the prognosis of patients with mild and moderate PSCl to a positive direction, which is worth popularizing.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R749.13

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