本文關鍵詞： 雌激素類 圍絕經期 抑郁癥 聯(lián)合治療 Meta分析　出處：《重慶醫(yī)學》2017年24期 　論文類型：期刊論文

【摘要】：目的系統(tǒng)評價雌激素聯(lián)合抗抑郁藥物治療我國圍絕經期婦女抑郁癥狀的臨床療效。方法計算機檢索中國生物醫(yī)學文獻光盤數(shù)據(jù)庫(CBMdisc)、中國知網(wǎng)(CNKI)、萬方數(shù)據(jù)知識服務平臺、PubMed、Cochrane Library和Google學術等電子數(shù)據(jù)庫,設置主題詞檢索1980年1月至2016年2月國內外發(fā)表的關于雌激素聯(lián)合抗抑郁藥物治療我國圍絕經期婦女抑郁的臨床效果評價的相關文獻。應用RevMan5.1軟件對納入文獻的研究數(shù)據(jù)及結果進行Meta分析。結果共納入15篇符合納入標準的文獻。數(shù)據(jù)合并結果顯示,與單獨使用雌激素治療組相比,雌激素聯(lián)合抗抑郁藥物治療組在有效率(RR=1.46,95%CI=1.29~1.66,P0.01)、HAMD評分(WMD=-4.61,95%CI=-5.63~-3.59,P0.01)和KMI評分(WMD=-5.83,95%CI=-11.12~-0.53,P0.01)3個方面差異有統(tǒng)計學意義。結論雌激素替代治療聯(lián)合抗抑郁藥物對臨床圍絕經期癥狀及抑郁癥狀的治療及緩解效果顯著優(yōu)于單獨使用雌激素替代治療。
[Abstract]:Objective to evaluate the clinical efficacy of estrogen combined with antidepressants in the treatment of depression in Chinese menopausal women. Electronic databases such as the PubMedine Cochrane Library and Google academic, To search the literature published from January 1980 to February 2016 on the evaluation of clinical efficacy of estrogen combined with antidepressants in the treatment of depression in menopausal women in China. The data and results of the study were analyzed by Meta. The results were included in 15 articles that met the inclusion criteria. Compared with the estrogen treatment group alone, The effective rate of estrogen combined with antidepressant therapy group was significantly different in three aspects: the effective rate of estrogen combined with antidepressant therapy was 1.29 ~ 1.66N P0.01a Hamd score and WMD-5.63 ~ -3.59% P0.01) and KMI score WMD-5.8395CI-11.12 ~ (12) -0.53N P0.01.Conclusion estrogen replacement therapy combined with antidepressant therapy has statistical significance in the treatment of peri-menopausal and depressive symptoms in patients with menopausal and depressant symptoms. [WT5HZ] [WT5BZ] there are significant differences in the efficacy of estrogen replacement therapy combined with antidepressant drugs in the treatment of peri-menopausal and depressive symptoms. The therapeutic and palliative effects were significantly better than that of estrogen replacement therapy alone.
【作者單位】： 廣東省江門市第三人民醫(yī)院精神二科;
【分類號】：R749.4

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