本文關(guān)鍵詞： 抽動障礙 阿立哌唑 隔日給藥 兒童　出處：《中國實用兒科雜志》2014年07期 　論文類型：期刊論文

【摘要】：目的比較小劑量阿立哌唑治療兒童抽動障礙隔日給藥與每日給藥的療效和安全性,探討阿立哌唑治療兒童抽動障礙的一種新的給藥方式。方法選取福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院兒童神經(jīng)內(nèi)科門診2008年9月至2012年10月就診的59例抽動障礙患兒,隨機(jī)分為兩組:隔日給藥組26例、每日給藥組33例,分別給予阿立哌唑1.25~10.0 mg(每2日1次)與2.5~10.0 mg(每日1次),共12周。采用耶魯綜合抽動嚴(yán)重程度量表(YGTSS)、不良反應(yīng)癥狀量表(TESS)于入組時,治療第2、4、8、12周末對患者評估臨床療效,并觀察不良反應(yīng)。結(jié)果隔日給藥組與每日給藥組在治療第2、4、8、12周末,YGTSS減分率差異均無統(tǒng)計學(xué)意義(t分別為0.267、-0.816、0.898、0.448,P均0.05)。根據(jù)YGTSS減分率評定標(biāo)準(zhǔn),治療第12周末,隔日給藥組和每日給藥組有效率分別為92.3%和90.9%,差異無統(tǒng)計學(xué)意義(P0.05)。治療12周后兩組不良反應(yīng)發(fā)生率分別為7.69%(2/26)與15.15%(5/33),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論小劑量阿立哌唑隔日給藥能有效改善運動及發(fā)聲抽動。
[Abstract]:Objective to compare the efficacy and safety of low dose aripiprazole in the treatment of children with tic disorder. To explore a new way of administration of aripiprazole in the treatment of children with tic disorder. Methods 59 children with tic disorder were selected from September 2008 to October 2012 in Department of Neurology of Union Hospital affiliated to Fujian Medical University. They were randomly divided into two groups: 26 cases in the next day group and 33 cases in the daily administration group. Aripiprazole 1.25v 10.0 mg (once per 2nd) and 2.5V 10.0 mg (once a day for 12 weeks) were given respectively. The clinical efficacy was evaluated at the end of 812 weeks with Yale comprehensive tic severity scale (YGTSS) and adverse reaction symptom scale (TESS). Results there was no significant difference in the score reduction rate of YGTSS between the two groups at the end of the 12th week of treatment. The scores of YGTSS were 0.267- 0.8160.8980.448p, respectively (P < 0.05). According to the evaluation standard of YGTSS score reduction rate, at the end of the 12th week of treatment, there was no significant difference between the two groups. The effective rates of the two groups were 92.3% and 90.9, respectively. There was no significant difference between the two groups (P 0.05). After 12 weeks of treatment, the incidence of adverse reactions in the two groups was 7.69g / 26) and 15.1550 / 33, respectively, with no significant difference (P 0.05). Conclusion A small dose of aripiprazole is given every other day. The drug can effectively improve movement and vocal twitch.
【作者單位】： 福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院兒科;
【分類號】：R749.94
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本文編號：1536443