本文關(guān)鍵詞： 孤獨(dú)癥譜系障礙 磁共振成像 彌散 各向異性　出處：《中國兒童保健雜志》2014年09期 　論文類型：期刊論文

【摘要】：目的探討孤獨(dú)癥譜系障礙兒童重要區(qū)域腦白質(zhì)的磁共振彌散張量成像(diffusion tensor imaging,DTI)特點(diǎn)。方法對37例男性孤獨(dú)癥譜系障礙兒童和16例正常發(fā)育男童進(jìn)行神經(jīng)心理評估及磁共振彌散張量成像技術(shù)掃描,比較兩組各向異性分?jǐn)?shù)(fractional anisotropy,FA)的差異,并分析孤獨(dú)癥組感興趣區(qū)FA值與兒童智能發(fā)展水平及臨床表現(xiàn)之間的關(guān)系。結(jié)果孤獨(dú)癥譜系障礙組的感興趣腦區(qū)FA值與對照組相比無明顯差異(P0.05)。孤獨(dú)癥譜系障礙組的左側(cè)額葉FA值與智能發(fā)展水平有相關(guān)性(P0.05)。孤獨(dú)癥譜系障礙兒童兒童期孤獨(dú)癥評定量表(The Childhood Autism Raling Scale,CARS)分級重度組比輕-中度組左側(cè)額葉FA值更低(P0.05)。結(jié)論左側(cè)額葉白質(zhì)損傷可能參與了孤獨(dú)癥譜系障礙的病例生理過程的變化。
[Abstract]:Objective to investigate the characteristics of diffusion Zhang Liang diffusion tensor imaging (DTI) in the white matter of children with autism spectrum disorders. Methods 37 male autistic children with spectrum disorders and 16 normal developmental boys were assessed with neuropsychological assessment and. Magnetic Resonance Diffusion Zhang Liang Imaging, The differences between the two groups of anisotropic fractional fractional anisotropic FAs are compared, The relationship between FA value of the region of interest in autism group and the level of intelligence development and clinical manifestation of children was analyzed. Results there was no significant difference in FA value between the autism spectrum disorder group and the control group (P 0.05). There was a correlation between the left frontal lobe FA value and the level of intelligence development in the children with autism spectrum disorder. The Childhood Autism Raling scale CARSs were lower in the severe group than in the mild to moderate group. Conclusion the left frontal lobe has a lower FA value in the left frontal lobe than that in the mild to moderate group. White matter damage may be involved in the physiological process of autism spectrum disorders.
【作者單位】： 南京醫(yī)科大學(xué)附屬無錫市人民醫(yī)院兒童保健科;南京醫(yī)科大學(xué)附屬無錫市人民醫(yī)院放射影像科;
【基金】：無錫市科技局社會發(fā)展項(xiàng)目(SCZ00N110)
【分類號】：R749.94

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