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  本文關(guān)鍵詞： 精神分裂癥 代謝綜合征 相關(guān)性　出處：《中國全科醫(yī)學》2014年34期 　論文類型：期刊論文

【摘要】：目的探討精神分裂癥與代謝綜合征(metabolic syndrome,MS)的關(guān)系。方法于2013年9—12月從六安市第二人民醫(yī)院精神衛(wèi)生中心2012年6月—2013年6月收治住院的2 899例精神疾病患者中,抽取符合納入、排除標準的773例。據(jù)2004年中華醫(yī)學會糖尿病分會(CDS,2004)MS診斷標準,按是否合并MS將其分為MS組和無MS組。采用自制一般情況調(diào)查表,分別對兩組患者的性別、年齡、住院天數(shù)、病程、抗精神病藥物種類、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、血壓(BP)、體質(zhì)指數(shù)(BMI)及吸煙史等資料進行比較。結(jié)果 773例精神分裂癥患者中有40.8%(315/773)合并MS。MS組患者的FPG、TG、BMI及血壓水平高于無MS組,HDL-C水平低于無MS組,差異有統(tǒng)計學意義(P0.01)。精神分裂癥患者MS的患病率比較,男性患者的患病率(161/409,39.4%)和女性患者的患病率(154/364,42.3%)差異無統(tǒng)計學意義(P0.05);50歲的患者的患病率(42/77,54.5%)高于30歲(83/222,37.4%)和30~50歲(190/474,40.1%)的患者,差異有統(tǒng)計學意義(P0.05);無吸煙史患者的患病率(162/456,35.5%)低于吸煙史10年(50/100,50.0%)和≥10年的患者(103/217,47.5%),差異有統(tǒng)計學意義(P0.05);病程10年的患者的患病率(128/271,47.2%)高于病程5年(62/172,36.0%)和5~10年的患者(125/330,37.9%),差異有統(tǒng)計學意義(P0.05)。使用不同抗精神病藥物的患者MS的患病率各不相同,但差異無統(tǒng)計學意義(P0.05)。多因素回歸分析顯示,性別、年齡、吸煙史及精神分裂癥病程對精神分裂癥是否合并MS的影響有統(tǒng)計學意義(P0.05)。結(jié)論精神分裂癥患者MS的患病率較一般人群要高,尤其是女性、年齡大、吸煙及病程長的患者,使用抗精神病藥物也可能是導致MS發(fā)病的危險因素。
[Abstract]:Objective to investigate the relationship between schizophrenia and metabolic syndrome (MS). Methods from 2013 to December, we selected 2 899 patients with mental diseases admitted from the Mental Health Center of the second people's Hospital of Luan City from June 2012 to June 2013. According to the diagnostic criteria of MS in 2004, the patients were divided into MS group and non-MS group according to whether they were combined with MS. The self-made general information questionnaire was used to analyze the sex, age and hospitalization days of the two groups. Course of disease, types of antipsychotics, Fasting blood glucose (FBG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), blood pressure (BP), body mass index (BMI) and smoking history were compared. Results 40.8% of 773 schizophrenic patients with MS.MS had higher MS.MS BMI and blood pressure. The level of HDL-C in MS free group was lower than that in no MS group. There was no significant difference in the prevalence of MS between male patients and female patients. There was no statistically significant difference in the prevalence of MS between male patients and female patients. There was no significant difference in the prevalence rate of P0.055-50 patients aged 50 years (P 0.05% 7754.545) higher than that of patients aged 30 years (8322227.44%) and 3050 years old (190-4740.10%). The difference was statistically significant (P 0.05); the prevalence rate of patients without smoking history was 162 / 4565.5kW) lower than that of patients with 10 years of smoking history (50 / 100 / 50.0) and those with more than 10 years (P = 103 / 21747.5m), the difference was statistically significant (P = 0.05a); the prevalence rate of patients with 10 years course of disease was 128271or 47.2) higher than that of patients with disease course of 5 years (62172n / 36.0) and 5- 10 years (P < 0.05). There was a statistically significant difference in the prevalence of MS among patients with different antipsychotics. But the difference was not statistically significant (P 0.05). Multivariate regression analysis showed that sex, age, The history of smoking and the course of schizophrenia have statistical significance on the influence of schizophrenia with MS. Conclusion the prevalence rate of MS in schizophrenic patients is higher than that in the general population, especially in females, older patients, smoking patients and patients with long course of disease. The use of antipsychotics may also be a risk factor for MS.
【作者單位】： 安徽醫(yī)科大學第一附屬醫(yī)院內(nèi)分泌科;六安市第二人民醫(yī)院內(nèi)分泌科;六安市第二人民醫(yī)院精神衛(wèi)生中心;
【分類號】：R749.3

【參考文獻】

相關(guān)期刊論文 前10條

1 王繼旺,張素華,任偉,杜娟,陳靜,包柄楠,李革,盧仙娥,馬貴成,張政,倪銀星;吸煙與代謝綜合征的相關(guān)性調(diào)查與分析[J];重慶醫(yī)學;2004年03期

2 陳松;楊貴剛;王志仁;王sユ，

本文編號：1498412