本文關(guān)鍵詞： 抑郁 氟西汀 氫質(zhì)子磁共振波譜分析　出處：《臨床神經(jīng)病學(xué)雜志》2014年01期 　論文類型：期刊論文

【摘要】：目的探討氟西汀干預(yù)對(duì)大鼠抑郁模型的海馬代謝的影響。方法 45只SD大鼠隨機(jī)分為正常對(duì)照組(n=15)以及抑郁組(n=30)。抑郁組又被分為干預(yù)亞組(n=15)及未干預(yù)亞組(n=15)。采用慢性不可預(yù)知應(yīng)激及孤養(yǎng)的方法建立抑郁模型。在制模成功后不干預(yù)亞組大鼠腹腔注射生理鹽水2.0 ml/d,干預(yù)亞組大鼠腹腔注射鹽酸氟西汀溶液5.0 mg/(kg·d);均持續(xù)4周。于干預(yù)前后對(duì)各組大鼠進(jìn)行氫質(zhì)子磁共振波譜分析檢查,并進(jìn)行比較。結(jié)果抑郁組大鼠雙側(cè)海馬N-乙酰天冬氨酸(NAA)/肌酸(Cr)及谷氨酸復(fù)合物(Glx)/Cr顯著低于正常對(duì)照組,膽堿復(fù)合物(Cho)/Cr及肌醇(mI)/Cr顯著高于正常對(duì)照組(P0.05~0.01)。干預(yù)亞組雙側(cè)海馬的NAA/Cr及Glx/Cr顯著高于未干預(yù)亞組雙側(cè)海馬的Cho,ho/Cr及右側(cè)海馬的mI/Cr顯著低于未干預(yù)亞組(P0.05~0.01)。與干預(yù)前比較,干預(yù)亞組干預(yù)后雙側(cè)海馬NAA/Cr及Glx/Cr顯著升高(均P0.05);未干預(yù)亞組雙側(cè)海馬Cho/Cr及mI/Cr顯著升高,NAA/Cr及Glx/Cr顯著降低(均P0.05)。結(jié)論氟西汀能夠改善海馬神經(jīng)細(xì)胞的谷氨酸循環(huán)及肌醇磷酸循環(huán),恢復(fù)神經(jīng)元及神經(jīng)膠質(zhì)細(xì)胞的功能。
[Abstract]:Objective to investigate the effect of fluoxetine intervention on hippocampal metabolism in rats with depression. Methods Forty-five SD rats were randomly divided into normal control group (n = 15) and depression group (n = 30). The depression model was established by the methods of chronic unpredictable stress and solitary nourishment. The rats in the control group were given intraperitoneal injection of normal saline 2.0 ml / d and the intervention subgroup received intraperitoneal injection of fluoxetine hydrochloride (5.0 mg/(kg 路d) for 4 weeks. Before and after intervention, the rats in each group were examined by proton magnetic resonance spectroscopy. Results in the depression group, the levels of NAANAA / creatine Cr) and glutamate complex in bilateral hippocampus of the depression group were significantly lower than those in the normal control group. The levels of NAA/Cr and Glx/Cr in the bilateral hippocampus of the intervention group were significantly higher than those of the control group (P0.050.01). The mI/Cr of the bilateral hippocampus of the intervention group was significantly lower than that of the non-intervention subgroup (P0.05P0.01), and the mI/Cr of the right hippocampus was significantly lower than that of the non-intervention subgroup. In the intervention subgroup, the NAA/Cr and Glx/Cr in the bilateral hippocampus increased significantly (all P 0.05), and the Cho/Cr and mI/Cr in the hippocampus in the control group increased significantly (P < 0.05). Conclusion Fluoxetine can improve the glutamate and inositol phosphoric acid circulation in the hippocampal neurons. To restore the function of neurons and glial cells.
【作者單位】： 江蘇大學(xué)附屬醫(yī)院神經(jīng)內(nèi)科;江蘇大學(xué)附屬醫(yī)院影像科;
【分類號(hào)】：R749.4

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本文編號(hào)：1498182