發(fā)布時(shí)間：2018-02-01 03:06

  本文關(guān)鍵詞： 可溶性CD配體 β淀粉樣蛋白- 卒中后認(rèn)知障礙 腦卒中　出處：《山東醫(yī)藥》2017年43期 　論文類型：期刊論文

【摘要】：目的探討血清可溶性CD40配體(s CD40L)、β淀粉樣蛋白1-42(Aβ1-42)水平對(duì)卒中后認(rèn)知障礙(PSCI)的診斷效能。方法急性腦梗死患者118例(腦梗死組),發(fā)病后3個(gè)月時(shí)進(jìn)行蒙特利爾量表(Mo CA)評(píng)分并據(jù)此將其分為腦梗死認(rèn)知障礙組64例、腦梗死認(rèn)知正常組54例,同期將51例身體健康者納入對(duì)照組。酶聯(lián)免疫吸附法檢測(cè)各組血清s CD40L、Aβ1-42,并進(jìn)行比較,分析血清s CD40L、Aβ1-42水平與腦梗死認(rèn)知障礙的關(guān)系,通過(guò)繪制受試者工作特征曲線(ROC)分析s CD40L、Aβ1-42水平對(duì)腦梗死認(rèn)知障礙的診斷效能。結(jié)果 (1)腦梗死認(rèn)知障礙組、腦梗死認(rèn)知正常組、對(duì)照組血清s CD40L水平分別為(3.820±1.236)、(3.261±1.131)、(2.663±1.303)ng/m L,三組間任意兩組相比,P均0.01;腦梗死認(rèn)知障礙組、腦梗死認(rèn)知正常組、對(duì)照組血清Aβ1-42水平分別為(94.404±37.332)、(127.936±34.877)、(158.023±35.994)pg/m L,三組間任意兩組相比,P均0.01。(2)腦梗死組血清s CD40L水平與Mo CA評(píng)分呈負(fù)相關(guān)(r=-0.640,P0.01),血清Aβ1-42水平與Mo CA評(píng)分呈正相關(guān)(r=0.758,P0.01),血清s CD40L水平與血清Aβ1-42水平呈負(fù)相關(guān)(r=-0.960,P0.01)。(3)腦梗死組血清s CD40L水平ROC的曲線下面積為0.644,血清Aβ1-42水平ROC的曲線下面積為0.740,血清s CD40L聯(lián)合Aβ1-42水平ROC的曲線下面積為0.918;根據(jù)約登指數(shù),入組時(shí)s CD40L值為3.60 ng/m L,其診斷腦梗死認(rèn)知障礙的陽(yáng)性預(yù)測(cè)值為71.154%、陰性預(yù)測(cè)值為59.091%、正確診斷率為57.812%;入組時(shí)Aβ1-42值為114.34 pg/m L,其診斷腦梗死認(rèn)知障礙的陽(yáng)性預(yù)測(cè)值為77.966%、陰性預(yù)測(cè)值為69.491%、正確診斷率為71.875%;s CD40L、Aβ1-42聯(lián)合應(yīng)用診斷腦梗死認(rèn)知障礙的陽(yáng)性預(yù)測(cè)值為89.855%、陰性預(yù)測(cè)值為95.918%、正確診斷率為96.875%。結(jié)論腦梗死認(rèn)知障礙患者血清s CD40L水平升高、Aβ1-42水平降低,兩者與Mo CA評(píng)分有關(guān),檢測(cè)血清s CD40L、Aβ1-42有助于PSCI的診斷。
[Abstract]:Objective to investigate the changes of serum soluble CD40 ligand (s CD40L), amyloid beta (A beta 1-42) 1-42 levels of cognitive disorder after stroke (PSCI) and the diagnostic efficacy. Methods 118 patients with acute cerebral infarction (ACI), 3 months after the onset of the Montreal scale (Mo CA) score and then it is divided into cerebral infarction group and 64 cases of cerebral infarction cognitive impairment, cognitive normal group of 54 cases, the same period 51 cases of healthy persons in the control group. Enzyme linked immunosorbent assay to detect the serum s CD40L, A beta 1-42, and carry on the comparison, analysis of serum s CD40L, A beta 1-42 level and cerebral infarction cognitive impairment. Through the receiver operating characteristic curve (ROC) analysis of s CD40L. The diagnostic efficacy of A beta 1-42 level on cerebral infarction cognitive impairment. The cognitive impairment (1) cerebral infarction group, cerebral infarction cognitive normal group, control group of serum s CD40L levels were (3.820 + 1.236), (3.261 + 1.131), (2.663. 1.303) ng/m L,涓夌粍闂翠換鎰忎袱緇勭浉姣，

本文編號(hào)：1480760