本文關(guān)鍵詞：利培酮治療額顳腦挫裂傷后精神癥狀的臨床研究　出處：《中國(guó)神經(jīng)精神疾病雜志》2015年04期 　論文類型：期刊論文

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【摘要】：目的觀察利培酮在額顳腦挫裂傷后精神癥狀臨床治療中的療效。方法選取2009年1月至2011年12月期間我院收治的60例額顳腦挫裂傷后伴有精神癥狀患者作為觀察對(duì)象,隨機(jī)分為對(duì)照組和治療組,對(duì)照組患者給予維生素B160mg/d,治療組患者給予利培酮1mg/d,2組療程均為1個(gè)月,分別于治療前、后使用陽(yáng)性與陰性癥狀量表(PANSS)與癥狀量表(TESS)對(duì)兩組患者的治療效果及不良反應(yīng)進(jìn)行評(píng)價(jià),對(duì)結(jié)果進(jìn)行對(duì)比分析。結(jié)果治療組治療開(kāi)始后第1、2、3、4周的PANSS評(píng)分明顯低于對(duì)照組,兩組對(duì)比差異具有統(tǒng)計(jì)學(xué)意義(F=48.12,P0.0001),時(shí)間對(duì)比差異具有統(tǒng)計(jì)學(xué)意義(F=290.99,P0.0001),組間與時(shí)間交互作用具有統(tǒng)計(jì)學(xué)意義(F=11.91,P0.0001)。經(jīng)控制時(shí)間點(diǎn)后兩組比較具體表現(xiàn)為治療開(kāi)始后第1、2、3、4周兩組對(duì)比差異具有統(tǒng)計(jì)學(xué)意義。治療過(guò)程中兩組患者均出現(xiàn)不同程度的頭痛、反胃、體重增加以及心動(dòng)過(guò)速等不良反應(yīng),均經(jīng)對(duì)癥處理后明顯緩解。結(jié)論利培酮可明顯改善患者額顳腦挫裂傷后精神癥狀,安全有效。
[Abstract]:Objective To observe the clinical curative effect of risperidone in the treatment of psychiatric symptoms of frontotemporal brain contusion after. Methods from January 2009 to December 2011 during the 60 cases of frontotemporal brain contusion and laceration in our hospital after the patients accompanied by mental symptoms as observation objects, and were randomly divided into control group and treatment group, the control group were treated with vitamin B160mg/d, patients in the treatment group were given in 1mg/d, the 2 groups were treated for 1 months, respectively before treatment, after the use of positive and negative symptom scale (PANSS) and symptom scale (TESS) and to evaluate the adverse reactions of two groups of patients, the results were compared. Results: patients in the treatment group after the start of the week 1,2,3,4 the PANSS score was significantly lower than the control group, with significant difference between the two groups (F=48.12, P0.0001), statistically significant time differences (F=290.99, P0.0001), and the interaction time between the groups was statistically The significance of (F=11.91, P0.0001). By controlling the time points after the two groups for specific performance was statistically significant after treatment began at 1,2,3,4 weeks. The differences between the two groups during the treatment of two groups of patients showed varying degrees of headache, nausea, weight gain and bradycardia adverse reaction rate, were relieved after symptomatic treatment conclusion risperidone can significantly improve patients with frontotemporal brain contusion after psychiatric symptoms, is safe and effective.

【作者單位】： 吉林省長(zhǎng)春市一汽總醫(yī)院神經(jīng)外科;
【分類號(hào)】：R749.3
【正文快照】： ??吉林省長(zhǎng)春市一汽總醫(yī)院神經(jīng)外科(長(zhǎng)春130011)精神障礙常見(jiàn)于腦器質(zhì)性損傷,腦挫裂傷后患者出現(xiàn)精神障礙要比發(fā)生腦震蕩、腦干損傷以及頭皮外傷患者發(fā)生精神障礙多[1]。研究顯示[2]腦挫裂傷后精神癥狀與顱腦損傷的部位緊密相關(guān), 額葉和顳葉損傷之后經(jīng)常會(huì)繼發(fā)精神障礙。本文

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