本文關(guān)鍵詞：文拉法辛聯(lián)合中藥治療中老年抑郁癥的臨床療效研究與ECT的相關(guān)因素分析　出處：《蘭州大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 文拉法辛 中藥 中老年抑郁癥 焦慮/軀體化因子 腦血流灌注斷層顯像

【摘要】：目的： 探討文拉法辛聯(lián)合中藥治療中老年抑郁癥的臨床療效及其與ECT的相關(guān)因素分析。 方法： 將89例符合國(guó)際疾病分類第十版(ICD-10)抑郁癥患者,按診療卡號(hào)的奇偶分為觀察組(45例)和對(duì)照組(44例)。對(duì)照組給予文拉法辛治療,觀察組在使用文拉法辛治療的同時(shí)給予中藥進(jìn)行聯(lián)合治療,采用漢密爾頓抑郁量表(HAMD24)評(píng)定臨床療效,不良反應(yīng)量表(TESS)評(píng)定副反應(yīng),分別在治療前和治療后第1,2,4,6,8周末評(píng)估其療效和安全性；并于治療前及治療第8周末進(jìn)行ECT檢查并記錄檢查結(jié)果。 結(jié)果： 1.與治療前比較,觀察組自第1周末HAMD24量表評(píng)分明顯降低,對(duì)照組自第2周末HAMD24量表評(píng)分才明顯降低,差異有統(tǒng)計(jì)學(xué)意義(P0.05)； 2.兩組焦慮／軀體化因子評(píng)分自第4周末起差異有統(tǒng)計(jì)學(xué)意義(P0.05)； 3.患者ECT檢查腦部灌注有無異常與患者年齡和病程呈正相關(guān),與文化程度及性別無相關(guān)性； 4.ECT檢查結(jié)果與焦慮／軀體化因子評(píng)分中度相關(guān)(r=0.67,P0.05)； 5.觀察組和對(duì)照組痊愈率(26.83%,22.50%)、有效率(87.80%,80.00%)差異無統(tǒng)計(jì)學(xué)意義(P0.05)不良反應(yīng)事件發(fā)生率差異無統(tǒng)計(jì)學(xué)意義(χ2=1.99,P0.05)。 結(jié)論： 1.年齡越愈大病程愈長(zhǎng),腦部斷層血流灌注異常愈明顯；年齡和病程是中老年人腦部血流異常的危險(xiǎn)因素； 2.焦慮／軀體化因子評(píng)分愈高,腦部斷層血流灌注異常愈明顯； 3.文拉法辛聯(lián)合中藥和單一文拉法辛治療中老年抑郁癥均有良好療效及安全性,但文拉法辛聯(lián)合中藥起效更快,值得臨床推廣。
[Abstract]:Objective: To investigate the clinical effect of venlafaxine combined with traditional Chinese medicine in the treatment of depression in middle and old age and its related factors with ECT. Methods: 89 patients with depression according to ICD-10 were divided into two groups: observation group (45 cases) and control group (44 cases). The control group was treated with venlafaxine. The observation group was treated with venlafaxine and combined with traditional Chinese medicine. The clinical efficacy was evaluated by Hamilton Depression scale (Hamd 24) and the side effects were evaluated by adverse reaction scale (TESS). The efficacy and safety were evaluated before and after treatment at the end of 8 weeks. ECT examination was performed before treatment and at the end of the 8th week of treatment, and the results were recorded. Results: 1. Compared with before treatment, the HAMD24 score of the observation group decreased significantly from the first weekend, and that of the control group decreased significantly from the 2nd weekend. The difference was statistically significant (P 0.05). 2. The scores of anxiety / somatization factor in the two groups were significantly different from the end of the 4th week (P 0.05). 3.The abnormal cerebral perfusion in ECT was positively correlated with age and course of disease, but had no correlation with education level and sex. 4. The results of ECT were moderately correlated with anxiety / somatization factor scores (P 0.05). 5. The cure rate of observation group and control group was 26.83% and 22.50%, and the effective rate was 87.80%. There was no significant difference in the incidence of adverse reaction events (蠂 2, 1.99, P 0.05). Conclusion: 1. The longer the age, the more obvious the abnormal perfusion of cerebral blood flow, age and course of disease are the risk factors of cerebral blood flow abnormality in the middle and old people. 2. The higher the score of anxiety / somatization factor, the more obvious the abnormal blood flow and perfusion in the brain; 3. Venlafaxine combined with Chinese medicine and venlafaxine alone have good efficacy and safety in the treatment of middle and old age depression, but venlafaxine combined with traditional Chinese medicine is more effective and worthy of clinical promotion.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R749.4

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