在睡眠剝奪（sleep deprivation,SD）過程中,人類大腦的神經(jīng)活動和警覺水平如何受到影響,尤其是感覺運(yùn)動和視覺系統(tǒng),目前仍是研究的熱點(diǎn).靜息狀態(tài)功能磁共振成像（resting state functional magnetic resonance imaging,rf MRI）作為一種反映人腦自發(fā)活動的非侵入式成像技術(shù),在睡眠剝奪的研究中得到了廣泛應(yīng)用.本研究采用9次重復(fù)rf MRI和心理運(yùn)動警覺任務(wù)（psychomotor vigilance task,PVT）,以探索23名志愿者在整個36 h的睡眠剝奪過程中神經(jīng)活動和警覺水平的變化.采用基于PVT的平均反應(yīng)時(shí)間（mean reaction time,MRT）和失效率（lapses ratio,LR）評估警覺水平的變化;采用基于rf MRI的區(qū)域同質(zhì)性（region homogeneity,Re Ho）和低頻波動幅度（amplitude of low frequency fluctuation,ALFF）評估大腦神經(jīng)活動變化.結(jié)果表明,感覺運(yùn)動網(wǎng)絡(luò)（sensorimotor network,SMN）和視覺區(qū)域（visu... 

【文章頁數(shù)】：18 頁

【文章目錄】：
1 Materials and methods
    1.1 Subjects and materials
    1.2 MRI data acquisition
    1.3 Data preprocessing
    1.4 Calculation of ReHo and ALFF
    1.5 Definitions of visual-related regions and sensorimotor-related regions
    1.6 Statistical analysis
2 Results
    2.1 Effect of SD on vigilance level
    2.2 Effect of SD on ReHo
    2.3 Effect of SD on ALFF
    2.4 Brain regions with both ReHo and ALFF affected
    2.5 Pattern of alteration of neural activities in SMN and VN regions
    2.6 Effects of sleep pressure,circadian rhythm and their interaction
    2.7 Results of correlation analysis
3 Discussion
4 Conclusion



本文編號：3730694