本文選題：前額葉皮層 + 紋狀體�。� 參考：《華東理工大學(xué)》2017年碩士論文

【摘要】：前額葉皮層和紋狀體是大腦內(nèi)兩個(gè)重要的區(qū)域,單細(xì)胞電生理記錄實(shí)驗(yàn)已發(fā)現(xiàn)前額葉皮層和紋狀體的神經(jīng)元能夠編碼獎(jiǎng)勵(lì)信息,但不清楚這兩個(gè)區(qū)域的局域場電位(local field potential,LFP)是否也能編碼獎(jiǎng)勵(lì)信息。為研究這個(gè)問題,當(dāng)猴子在進(jìn)行一個(gè)獎(jiǎng)勵(lì)預(yù)測實(shí)驗(yàn)時(shí),用多通道電極同時(shí)記錄了前額葉皮層和紋狀體的局域場電位。采用短時(shí)傅里葉變換,將記錄的局域場電位轉(zhuǎn)換為時(shí)、頻域上的信號(hào),比較不同獎(jiǎng)勵(lì)條件(大水和小水)下功率值的分布。結(jié)果發(fā)現(xiàn)大約40%的通道能夠區(qū)分不同的獎(jiǎng)勵(lì)條件,并且小水條件下的功率值大于大水條件下的功率值;進(jìn)一步發(fā)現(xiàn)局域場電位在β頻段(14-30Hz)上的功率值差別最顯著。說明前額葉皮層和紋狀體的局域場電位能夠有效地編碼獎(jiǎng)勵(lì)信息,主要是在β頻段,有助于進(jìn)一步理解局域場電位在處理獎(jiǎng)勵(lì)信息過程的作用。同時(shí),本文采用格蘭杰預(yù)測的方法計(jì)算了前額葉皮層到紋狀體和紋狀體到前額葉皮層兩個(gè)方向在刺激前后的連接系數(shù),比較結(jié)果顯示:大、小水條件下,刺激后的兩個(gè)腦區(qū)之間的連接強(qiáng)度均增大,且紋狀體到前額葉皮層方向的連接系數(shù)增幅高于前額葉皮層到紋狀體方向,可能紋狀體向前額葉皮層提供了更多的信息。
[Abstract]:The prefrontal cortex and striatum are two important regions of the brain. Single cell electrophysiological recording experiments have found that neurons in the prefrontal cortex and striatum encode reward information.However, it is not clear whether the local field potential LFPs in these two regions can also encode reward information.To study this problem, local field potentials in the prefrontal cortex and striatum were simultaneously recorded using multi-channel electrodes in a reward prediction experiment.Using short time Fourier transform (STFT), the recorded local field potential (LFS) is converted to time, and the signals in frequency domain are compared to compare the distribution of power values under different reward conditions (big water and small water).The results show that about 40% of the channels can distinguish different reward conditions, and the power value of small water is higher than that of large water, and the local field potential has the most significant difference in 尾 -band 14-30 Hz.It is suggested that the local field potential in the prefrontal cortex and striatum can effectively encode reward information, mainly in the 尾 band, which is helpful to further understand the role of local field potential in the process of processing reward information.At the same time, Granger prediction was used to calculate the connection coefficients between prefrontal cortex to striatum and striatum to prefrontal cortex before and after stimulation.The intensity of connection between the two brain regions increased after stimulation, and the increase of the connectivity coefficient between striatum and prefrontal cortex was higher than that between prefrontal cortex and striatum, which may provide more information for the former frontal cortex of striatum.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R338

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 鄭金龍;趙連東;曹向陽;張?jiān)鰪?qiáng);舒斯云;;紋狀體參與聯(lián)想學(xué)習(xí)記憶的功能磁共振成像和臨床研究[J];中華行為醫(yī)學(xué)與腦科學(xué)雜志;2009年10期

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