TCRαβ分子識(shí)別抗原肽-MHC復(fù)合物的爭(zhēng)議問題探討
發(fā)布時(shí)間:2018-03-16 13:51
本文選題:抗原肽 切入點(diǎn):分子識(shí)別 出處:《中國(guó)免疫學(xué)雜志》2013年01期 論文類型:期刊論文
【摘要】:正T細(xì)胞抗原受體(TCR)是T細(xì)胞表面的特征性標(biāo)志分子,其與CD3分子組成的TCR-CD3復(fù)合體,是進(jìn)行抗原識(shí)別,發(fā)揮細(xì)胞免疫重要功能的基礎(chǔ)。一般認(rèn)為,TCR必須識(shí)別抗原肽-MHC分子復(fù)合物才能活化T細(xì)胞,其中CD4+T細(xì)胞識(shí)別MHCⅡ類抗原,CD8+T細(xì)胞識(shí)別MHCⅠ類抗原。TCR分子
[Abstract]:Normal T cell antigen receptor (TCR) is a characteristic marker molecule on the surface of T cells. It is a TCR-CD3 complex with CD3 molecule, which is used for antigen recognition. It is generally believed that TCRs must recognize antigenic peptide -MHC molecular complexes to activate T cells, in which CD4 T cells recognize MHC class 鈪,
本文編號(hào):1620200
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