本文選題：白地霉　切入點(diǎn)：林生地霉　出處：《中國皮膚性病學(xué)雜志》2013年06期 　論文類型：期刊論文

【摘要】：目的通過建立真菌透甲模型,探討林生地霉、白地霉在體外能否侵犯健康甲板。方法以紅色毛癬菌作為陽性對照,制備透甲模型,分為林生地霉組、白地霉組和紅色毛癬菌組,觀察并記錄各組透甲時間,采用統(tǒng)計(jì)學(xué)方法比較是否存在差異性。采用掃描電鏡觀察受侵甲板的微觀變化。結(jié)果三株真菌的菌絲均能穿透甲板,其中林生地霉組的透甲時間為(15.07±3.28)d,白地霉組為(14.50±1.67)d,紅色毛癬菌組為(6.76±1.72)d。林生地霉組和白地霉組的透甲時間均明顯長于紅色毛癬菌組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),林生地霉組和白地霉組的透甲時間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。掃描電鏡觀察到三種菌株均有菌絲從角化細(xì)胞縫隙及細(xì)胞中央穿過,相對于健康甲板,受侵甲板背側(cè)面角化細(xì)胞"魚鱗樣"排列消失,邊緣模糊,細(xì)胞間隙寬窄不等,腹側(cè)面角化細(xì)胞未見明顯變化。結(jié)論林生地霉和白地霉均能穿透甲板,但侵襲力較紅色毛癬菌弱。
[Abstract]:Objective to establish a fungus through armour model, and to investigate whether Trichophyton woodland and Trichophyton albicans can invade the health deck in vitro. Methods the model was made by using Trichophyton rubrum as positive control, and was divided into three groups: dipyridium forest group, Trichophyton albicans group and Trichophyton rubrum group. The time of penetration was observed and recorded, and the difference was compared by statistical method. The microscopic changes of the invading deck were observed by scanning electron microscope. Results the mycelium of the three fungi could penetrate the deck. The time of nail penetration was 15.07 鹵3.28 days in Trichoderma forest group, 14.50 鹵1.67 days in Trichophyton albicans group and 6.76 鹵1.72 days in Trichophyton rubrum group. The penetration time of Trichophyton rubrum group and Trichophyton albicans group was significantly longer than that of Trichophyton rubrum group. The difference was statistically significant (P 0.05), but there was no significant difference in the penetration time between the two groups. Scanning electron microscope showed that the mycelium passed through the keratinocyte crevice and the center of the cell, as opposed to the healthy deck. The "ichthyosis" of keratinocytes in the dorsal side of the invaded deck disappeared, the edges were blurred, the intercellular space was not narrow, and the keratinocytes of the ventral side did not change obviously. Conclusion both Trichoderma plantarum and Dipyridium albicans can penetrate the deck. But the invasiveness was weaker than that of Trichophyton rubrum.
【作者單位】： 河北醫(yī)科大學(xué)第四醫(yī)院皮膚科;承德醫(yī)學(xué)院附屬醫(yī)院皮膚科;
【分類號】：R379.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 簡華慧,雷鵬程,董黎暉;48例可疑甲真菌病的病甲掃描電鏡分析[J];臨床皮膚科雜志;2001年04期

2 胡志敏;江萍;董碧麟;徐續(xù)玲;曾志良;董玉潔;周小勇;孫曾拯;;武漢地區(qū)甲真菌病的致病菌及菌種變遷分析[J];中國皮膚性病學(xué)雜志;2006年10期

3 甲真菌病調(diào)查協(xié)作組;甲真菌病患者生活質(zhì)量調(diào)查研究[J];中華皮膚科雜志;2001年05期

4 李秀麗,朱敬先,林元珠,高順強(qiáng),白逢彥;我國首見由地霉引起的膿癬一例及實(shí)驗(yàn)研究[J];中華皮膚科雜志;2004年08期

5 高順強(qiáng);朱敬先;林元珠;唐旭華;康瑞花;;中毒性表皮壞死松解癥伴發(fā)林生地霉感染一例[J];中華皮膚科雜志;2006年11期

6 李福秋;曲生明;李若瑜;王家俊;劉斌;賴維;鄭岳臣;金學(xué)洙;;2004年中國部分地區(qū)甲真菌病致病菌調(diào)查[J];中華皮膚科雜志;2006年12期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李昌吉;張貴;王晶瑜;;111例酒泉地區(qū)甲真菌病危險因素的病例對照研究[J];當(dāng)代醫(yī)學(xué);2010年20期

2 黃欣;施偉民;騰飛;袁偉;沈亮亮;史玉玲;張國娣;梁廣智;王偉平;李永銳;劉丁;郭文麗;;上海和洛陽地區(qū)甲真菌病患者生活質(zhì)量的比較研究[J];第二軍醫(yī)大學(xué)學(xué)報;2008年03期

3 徐明;張弘;陳靜;;505例甲真菌病真菌培養(yǎng)結(jié)果分析[J];福建醫(yī)藥雜志;2009年01期

4 施海玲;;艦艇人員手足癬的防治[J];海軍醫(yī)學(xué)雜志;2011年06期

5 謝倩;劉恩讓;劉麗;陳恒;;260例甲真菌病病原菌的分離培養(yǎng)[J];吉林醫(yī)學(xué);2011年20期

6 金云;江情;李智華;羅云鵬;陶麗;占萍;;API 20C和科瑪嘉顯色培養(yǎng)鑒定酵母菌的比較[J];實(shí)驗(yàn)與檢驗(yàn)醫(yī)學(xué);2010年05期

7 羅云鵬;占萍;李智華;陶麗;金云;江情;周柳華;譚立明;;105例甲真菌病臨床及致病菌分析[J];實(shí)驗(yàn)與檢驗(yàn)醫(yī)學(xué);2012年01期

8 余進(jìn);李若瑜;王曉紅;萬U，

本文編號：1610626