隱源性機(jī)化性肺炎:32例臨床、影像學(xué)資料分析
發(fā)布時(shí)間:2019-05-28 11:43
【摘要】:目的:分析32例隱源性機(jī)化性肺炎(COP)的臨床和影像學(xué)特征并復(fù)習(xí)有關(guān)文獻(xiàn),以提高對(duì)該病的診治水平。方法:搜集整理2012年12月~2016年12月病理確診的32例COP病人的一般資料、實(shí)驗(yàn)室檢查、肺功能和動(dòng)脈血?dú)夥治、臨床表現(xiàn)及影像學(xué)特征,并對(duì)這些數(shù)據(jù)資料進(jìn)行回顧性總結(jié)分析。結(jié)果:32例COP患者中,男性多于女性(21/11),年齡主要分布于46~75歲(平均年齡60.4±14.5歲),其中吸煙者占12.5%;臨床表現(xiàn)以咳痰(53.1%)最常見(jiàn),痰量較少,其余癥狀依次為呼吸困難(25.0%)、胸痛(25.0%)、干咳(21.9%)、痰中帶血(21.9%)、體重減輕(15.6%)、發(fā)熱(12.5%)、盜汗(12.5%)及乏力(9.4%);實(shí)驗(yàn)室檢查:血常規(guī)白細(xì)胞水平多為正常(87.5%),但絕大部分患者呈現(xiàn)血沉增快(94.1%)及C反應(yīng)蛋白(86.7%)增高;半數(shù)以上患者存在輕度的限制性通氣功能障礙;部分患者有輕度低氧血癥(45.5%);胸部CT表現(xiàn)以磨玻璃影最常見(jiàn)(22例,68.8%)、其次為斑片狀實(shí)變(13例,40.6%)或軟組織腫塊影(10例,31.3%),少數(shù)表現(xiàn)為結(jié)節(jié)、條索狀病灶、空洞、蜂窩狀病變及胸腔積液。結(jié)節(jié)和腫塊型隱源性機(jī)化性肺炎(NMCOP)共17例,其一般情況及實(shí)驗(yàn)室檢查:男性多于女性(11/6),年齡主要分布于47~66歲(平均年齡56.3±9.6歲),吸煙占28.6%;臨床癥狀依次為咳嗽咳痰(70.6%)、胸痛(23.5%)、痰中帶血(23.5%);僅1例(5.9%)CEA升高,其他腫瘤標(biāo)記物均為陰性,3例(17.6%)D-二聚體升高;胸部CT表現(xiàn):不規(guī)則形病灶11例(64.7%),圓形或者類(lèi)圓形病灶6例(35.3%);邊緣模糊12例(70.6%),邊緣清晰5例(29.4%);淺分葉5例(29.4%),深分葉2例(11.8%);長(zhǎng)毛刺2例(11.8%),短毛刺1例(5.9%);血管集束征2例(11.8%),棘突征6例(35.3%),在6例累及胸膜者中,僅1例(16.7%,1/6)有脂肪間隙。結(jié)論:COP臨床表現(xiàn)、實(shí)驗(yàn)室檢查及影像學(xué)多無(wú)明顯特異性,確診仍需依賴(lài)病理學(xué)診斷,對(duì)以磨玻璃樣影和實(shí)變影或結(jié)節(jié)和腫塊樣表現(xiàn)的患者,必須結(jié)合患者的臨床資料和胸部影像學(xué)表現(xiàn)進(jìn)行綜合分析,及時(shí)行肺組織病理活檢,有助于排除其它疾病尤其肺癌,減少誤診。
[Abstract]:Objective: to analyze the clinical and imaging features of 32 cases of cryptogenic organic pneumonia (COP) and review the relevant literature in order to improve the diagnosis and treatment of the disease. Methods: the general data, laboratory examination, pulmonary function and arterial blood gas analysis, clinical manifestations and imaging features of 32 patients with COP diagnosed pathologically from December 2012 to December 2016 were collected and analyzed. Results: among the 32 patients with COP, there were more males than females (21 鈮,
本文編號(hào):2487020
[Abstract]:Objective: to analyze the clinical and imaging features of 32 cases of cryptogenic organic pneumonia (COP) and review the relevant literature in order to improve the diagnosis and treatment of the disease. Methods: the general data, laboratory examination, pulmonary function and arterial blood gas analysis, clinical manifestations and imaging features of 32 patients with COP diagnosed pathologically from December 2012 to December 2016 were collected and analyzed. Results: among the 32 patients with COP, there were more males than females (21 鈮,
本文編號(hào):2487020
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