【摘要】：目的探討多沙普侖聯(lián)合無(wú)創(chuàng)通氣治療慢性阻塞性肺疾病(COPD)肺性腦病的臨床價(jià)值。方法選擇80例患者,分為兩組各40例,對(duì)照組應(yīng)用無(wú)創(chuàng)通氣,觀察組在對(duì)照組基礎(chǔ)上使用多沙普侖,治療后12 h,比較兩組患者血?dú)夥治鼋Y(jié)果,呼吸頻率及潮氣量變化情況,統(tǒng)計(jì)兩組治療轉(zhuǎn)歸。結(jié)果治療后12 h,觀察組pH高于對(duì)照組,血氧飽和度(SpO2)高于對(duì)照組,二氧化碳分壓(PCO2)低于對(duì)照組,氧分壓(PO2)高于對(duì)照組,呼吸頻率快于對(duì)照組,潮氣量小于對(duì)照組,使用無(wú)創(chuàng)呼吸機(jī)后好轉(zhuǎn)脫機(jī)高于對(duì)照組,臨床死亡率低于對(duì)照組(均P0.05)。結(jié)論對(duì)于COPD出現(xiàn)肺性腦病患者,使用多沙普侖聯(lián)合無(wú)創(chuàng)通氣,有效避免了有創(chuàng)通氣引起的并發(fā)癥,能更好地改善患者缺氧及二氧化碳潴留,提高患者預(yù)后。
[Abstract]:Objective to evaluate the clinical value of doxapron combined with noninvasive ventilation in the treatment of chronic obstructive pulmonary disease (COPD) with pulmonary encephalopathy. Methods 80 patients were divided into two groups: control group (n = 40) and control group (n = 40). The observation group was treated with doxapron on the basis of control group. 12 hours after treatment, the results of blood gas analysis, respiratory frequency and tidal volume were compared between the two groups. The outcome of treatment in the two groups was counted. Results 12 hours after treatment, pH in the observation group was higher than that in the control group, blood oxygen saturation (SpO2) was higher than that in the control group, partial pressure of carbon dioxide (PCO2) was lower than that in the control group, partial pressure of oxygen (PO2) was higher than that in the control group, and respiratory frequency was faster than that in the control group. The tidal volume was smaller than that of the control group, and the clinical mortality of the control group was lower than that of the control group (P 0.05). Conclusion Doxapron combined with noninvasive ventilation can effectively avoid the complications caused by invasive ventilation, improve hypoxia and carbon dioxide retention and improve the prognosis of patients with pulmonary encephalopathy in COPD.
【作者單位】： 蒼南縣人民醫(yī)院;
【分類(lèi)號(hào)】：R563.9;R747.9

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