【摘要】：目的探討非粒細(xì)胞缺乏侵襲性肺曲霉病(IPA)患者血清中IL-17、Dectin-1水平的變化及其意義。方法分別收集23例確診及臨床診斷為IPA的非粒細(xì)胞缺乏患者(IPA組)、31例臨床診斷為肺炎患者(肺炎組)和51例健康體檢者(對(duì)照組)的資料,應(yīng)用ELISA法測(cè)定血清IL-17含量;同時(shí)檢測(cè)IPA組及對(duì)照組血清Dectin-1含量,并測(cè)定IPA組患者血清G試驗(yàn)、GM試驗(yàn)、外周血白細(xì)胞計(jì)數(shù)和血清CRP的水平,隨訪患者預(yù)后,分析血清IL-17與其相關(guān)性。結(jié)果 IPA組患者血清IL-17含量明顯高于對(duì)照組(P0.05);肺炎組患者血清IL-17水平與對(duì)照組差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);IPA組血清Dectin-1含量明顯高于對(duì)照組(P0.05);IPA組血清IL-17與Dectin-1水平呈正相關(guān)(r=0.81,P0.05);IPA組血清IL-17、Dectin-1水平與G試驗(yàn)、GM試驗(yàn)、白細(xì)胞、CRP及患者的預(yù)后無(wú)相關(guān)性(P0.05)。結(jié)論非粒細(xì)胞缺乏宿主曲霉感染時(shí)刺激Dectin-1產(chǎn)生,激活Th17細(xì)胞免疫反應(yīng),且兩者間存在相關(guān)性。
[Abstract]:Objective to investigate the changes and significance of serum IL-17,Dectin-1 levels in patients with non-granulocytopenia invasive pulmonary aspergillosis (IPA). Methods the data of 23 patients with non-granulocyte deficiency (IPA) diagnosed and clinically diagnosed as IPA, 31 patients with pneumonia (pneumonia group) and 51 healthy controls (control group) were collected. The content of serum IL-17 was determined by ELISA. At the same time, the levels of serum Dectin-1 in IPA group and control group were measured, and the serum G test, GM test, white blood cell count in peripheral blood and serum CRP level in IPA group were measured. The prognosis of patients was followed up and the correlation between serum IL-17 and serum IL-17 was analyzed. Results the level of serum IL-17 in the IPA group was significantly higher than that in the control group (P0.05), and there was no significant difference in the serum IL-17 level between the pneumonia group and the control group (P0.05). The level of serum Dectin-1 in IPA group was significantly higher than that in control group (P 0.05). There was a positive correlation between serum IL-17 and Dectin-1 level in); IPA group (r = 0.81, P0.05). There was no correlation between serum IL-17,Dectin-1 level and G test, GM test, leukocyte, CRP and prognosis in IPA group (P0.05). Conclusion non-granulocyte lack of host Aspergillus infection stimulates the production of Dectin-1 and activates the immune response of Th17 cells, and there is a correlation between them.
【作者單位】： 南方醫(yī)科大學(xué)南京臨床學(xué)院(南京軍區(qū)南京總醫(yī)院)呼吸與危重癥醫(yī)學(xué)科;
【基金】：國(guó)家自然科學(xué)基金-青年科學(xué)基金(81000003) 南京軍區(qū)南京總醫(yī)院院管課題(2011028)
【分類號(hào)】：R519

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