【摘要】：目的系統(tǒng)評(píng)價(jià)血必凈注射液聯(lián)合常規(guī)治療慢性阻塞性肺疾病(COPD)的臨床療效和安全性。方法計(jì)算機(jī)檢索PubM ed、CENTRAL、EMbase、VIP、CNKI、CBM和Wan Fang等數(shù)據(jù)庫(kù),納入隨機(jī)對(duì)照試驗(yàn),經(jīng)過(guò)文獻(xiàn)篩選和評(píng)價(jià)質(zhì)量后提取有效數(shù)據(jù)進(jìn)行Meta分析。結(jié)果共納入41個(gè)隨機(jī)對(duì)照試驗(yàn)(RCT),合計(jì)3 032例患者。Meta分析結(jié)果顯示,血必凈注射液聯(lián)合常規(guī)治療COPD在總有效率[OR=3.39,95%CI(2.64,4.34),P0.000 01]、FEV1占預(yù)計(jì)值百分比(FEV1%)[WMD=8.67,95%CI(5.62,11.71),P0.000 01]、第一秒用力呼氣量/用力肺活量(FEV1/FVC)[WMD=6.17,95%CI(3.31,9.02),P0.000 1]、氧分壓(PaO 2)[WMD=6.45,95%CI(4.26,8.64),P0.000 01]、二氧化碳分壓(PaC O2)[WMD=4.35,95%CI(3.17,5.52),P0.000 01]、C反應(yīng)蛋白(CRP)[WMD=13.36,95%CI(9.95,16.77),P0.000 01]、酸堿度(pH)[WMD=0.03,95%CI(0.02,0.04),P0.000 01]、白細(xì)胞總數(shù)(WBC)[WMD=2.11,95%CI(1.64,2.58),P0.000 01]、中性粒細(xì)胞百分比(N%)[WMD=5.18,95%CI(3.49,6.86),P0.000 01]和住院時(shí)間[WMD=-4.77,95%CI(-6.33,-3.22),P0.000 01]等指標(biāo)上優(yōu)于單用常規(guī)治療,其差異均具有統(tǒng)計(jì)學(xué)意義。結(jié)論血必凈注射液聯(lián)合常規(guī)治療COPD的臨床療效優(yōu)于單用常規(guī)治療。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Xuebijing injection combined with routine therapy for chronic obstructive pulmonary disease (COPD). Methods PubM ed,CENTRAL,EMbase,VIP,CNKI,CBM and Wan Fang databases were searched by computer, and were included in randomized controlled trials. After literature screening and quality evaluation, effective data were extracted for Meta analysis. Results A total of 3 032 patients were enrolled in 41 randomized controlled trials (RCT),). The results of Meta analysis showed that Xuebijing injection combined with routine treatment of COPD had a total effective rate [OR=3.39,95%CI (2.64 鹵4.34), P0.00001]. FEV1 as a percentage of predicted value (FEV1%) [WMD=8.67,95%CI (5.62 鹵11.71), P0.00001], forced expiratory volume / forced vital capacity (FEV1/FVC) in the first second [WMD=6.17,95%CI (3.31 鹵9.02), P0.000 1], Partial pressure of oxygen (PaO 2) [WMD=6.45,95%CI (4.260.64), P 0.00001], partial pressure of carbon dioxide (PaC O 2) [WMD=4.35,95%CI (3.175.52), P 0.00001], C-reactive protein (CRP) [WMD=13.36,95%CI (9.95c16.77), P0.00001], pH (pH) [WMD=0.03,95%CI (0.02n 0.04), P0.00001], WBC total (WBC) [WMD=2.11,95%CI (1.64m2.58)], Percentage of neutrophils (N%) [WMD=5.18,95%CI (3.49 鹵6.86), P0.00001] and length of stay [WMD=-4.77,95%CI (-6.33% -3.22)], P 0.000 01] and other indexes were better than those of routine therapy alone, and the differences were statistically significant. Conclusion Xuebijing injection combined with routine therapy is superior to conventional therapy in the treatment of COPD.
【作者單位】： 廣州中醫(yī)藥大學(xué);
【基金】：2015年國(guó)家級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練項(xiàng)目(201510572007)
【分類號(hào)】：R563.9

【相似文獻(xiàn)】

中國(guó)期刊全文數(shù)據(jù)庫(kù) 前10條

1 剛麗;孫曉義;蔣志宏;寇露鑫;;血必凈注射液治療急性呼吸窘迫綜合征的療效觀察[J];疑難病雜志;2007年06期

2 王傳;邢蓉;許善初;;血必凈注射液細(xì)菌內(nèi)毒素檢查法的研究[J];安徽衛(wèi)生職業(yè)技術(shù)學(xué)院學(xué)報(bào);2007年05期

3 黃慶;勞永光;葉喬冬;李新梅;;血必凈注射液治療急性呼吸窘迫綜合征的療效觀察[J];廣東醫(yī)學(xué)院學(xué)報(bào);2008年06期

4 周忠東;陸遠(yuǎn)強(qiáng);楊林;陳大方;黃衛(wèi)東;;血必凈注射液對(duì)嚴(yán)重創(chuàng)傷患者外周血T淋巴細(xì)胞亞群變化的干預(yù)研究[J];中國(guó)中西醫(yī)結(jié)合急救雜志;2008年02期

5 張淑芬;;血必凈注射液的臨床應(yīng)用概況[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2008年15期

6 應(yīng)佑華;王征;;血必凈注射液輔助治療手術(shù)后肺炎35例[J];醫(yī)藥導(dǎo)報(bào);2008年07期

7 郭夢(mèng)圓;;血必凈注射液治療慢性肺心病臨床觀察[J];中國(guó)中醫(yī)急癥;2009年05期

8 華玉淑;謝興宇;謝毅;穆瓊;羅語(yǔ)思;;血必凈注射液治療老齡非ST段抬高急性冠脈綜合征36例報(bào)告[J];吉林大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2009年05期

9 張曉霞;李春梅;呂建平;;血必凈注射液的臨床應(yīng)用[J];疾病監(jiān)測(cè)與控制;2009年04期

10 孫衛(wèi)軍;林觀樣;;血必凈注射液的不良反應(yīng)監(jiān)察[J];海峽藥學(xué);2010年02期

中國(guó)重要會(huì)議論文全文數(shù)據(jù)庫(kù) 前10條

1 邱曉華;劉松橋;楊毅;邱海波;穆心葦;陳華堯;鄭瑞強(qiáng);嚴(yán)潔;葉正龍;常榮華;高永河;;血必凈注射液治療急性呼吸窘迫綜合征的多中心隨機(jī)對(duì)照臨床研究[A];第三屆重癥醫(yī)學(xué)大會(huì)論文匯編[C];2009年

2 瞿秋;楊菊;張燕祺;;血必凈注射液輔助治療老年下呼吸道感染療效觀察[A];第十次全國(guó)中西醫(yī)結(jié)合防治呼吸系統(tǒng)疾病學(xué)術(shù)研討會(huì)論文集[C];2009年

3 郭楠;劉清泉;苗清;江其敏;;血必凈注射液治療彌漫性血管內(nèi)凝血4例臨床報(bào)告[A];2006年全國(guó)危重病急救醫(yī)學(xué)學(xué)術(shù)會(huì)議論文集[C];2006年

4 劉松橋;鄭瑞強(qiáng);李茂琴;嚴(yán)潔;陳華堯;穆心葦;常榮華;葉正龍;李小石;高永河;邱曉華;黃英姿;郭鳳梅;楊毅;邱海波;;血必凈注射液治療急性呼吸窘迫綜合征的多中心前瞻性隨機(jī)對(duì)照臨床研究[A];中華醫(yī)學(xué)會(huì)急診醫(yī)學(xué)分會(huì)第十六次全國(guó)急診醫(yī)學(xué)學(xué)術(shù)年會(huì)論文集[C];2013年

5 郭楠;劉清泉;苗清;江其敏;;血必凈注射液治療彌漫性血管內(nèi)凝血4例臨床報(bào)告[A];中華中醫(yī)藥學(xué)會(huì)第六屆急診學(xué)術(shù)年會(huì)論文集[C];2006年

6 姜小敢;魯衛(wèi)華;金孝\，

本文編號(hào)：2428242