醫(yī)院獲得性肺炎預(yù)后及鮑曼不動(dòng)桿菌感染危險(xiǎn)因素分析
發(fā)布時(shí)間:2018-12-24 10:36
【摘要】:目的:對(duì)我院患者感染鮑曼不動(dòng)桿菌(AB)發(fā)生的醫(yī)院獲得性肺炎(HAP)的危險(xiǎn)因素和醫(yī)院獲得性肺炎患者的預(yù)后進(jìn)行回顧性分析,為預(yù)防和治療醫(yī)院獲得性肺炎尤其是鮑曼不動(dòng)桿菌感染的醫(yī)院獲得性肺炎提供依據(jù)。方法:選取2014年1月至2015年12月我院醫(yī)院獲得性肺炎(HAP)患者,根據(jù)痰培養(yǎng)結(jié)果分為鮑曼不動(dòng)桿菌感染的HAP和非鮑曼不動(dòng)桿菌感染的HAP患者,進(jìn)行HAP患者感染鮑曼不動(dòng)桿菌的危險(xiǎn)因素和HAP患者預(yù)后分析。查閱病歷、痰培養(yǎng)、實(shí)驗(yàn)室檢查及影像學(xué)檢查結(jié)果,通過(guò)APACHE Ⅱ評(píng)分來(lái)評(píng)價(jià)病情的嚴(yán)重程度。以SPSS22.0軟件進(jìn)行統(tǒng)計(jì)分析,采用卡方檢驗(yàn)比較分類(lèi)變量,P0.05表示差異有統(tǒng)計(jì)學(xué)意義。將單因素分析提示具有統(tǒng)計(jì)學(xué)意義數(shù)據(jù),則進(jìn)一步通過(guò)多元logistic回歸因素對(duì)這些數(shù)據(jù)進(jìn)行分析,評(píng)價(jià)醫(yī)院獲得性肺炎患者感染鮑曼不動(dòng)桿菌的危險(xiǎn)因素與醫(yī)院獲得性肺炎預(yù)后相關(guān)的危險(xiǎn)因素。結(jié)果:一.基本信息1.患者基本情況及科室分布共收集醫(yī)院獲得性肺炎共114例,其中呼吸機(jī)相關(guān)性肺炎15例。男性80例,女性34例,平均年齡55.99±19.24歲,患者死亡49例,患者生存65例。其中診斷科室前五位為外科ICU、內(nèi)科ICU、血液科、感染科、神經(jīng)外科。2.患者感染前接受手術(shù)、有創(chuàng)操作和抗菌藥物治療情況感染前進(jìn)行手術(shù)操作的有45例(39.5%),感染前進(jìn)行過(guò)機(jī)械通氣的有31例(其中包括16例病人在手術(shù)時(shí)進(jìn)行了短暫的機(jī)械通氣)(27.2%)。感染前使用抗生素的有110例(96%)。3.痰培養(yǎng)細(xì)菌結(jié)果與藥敏分析患者住院后痰培養(yǎng)細(xì)菌有:鮑曼不動(dòng)桿菌29例,肺炎克雷伯菌18例,銅綠假單胞菌14例等。鮑曼不動(dòng)桿菌對(duì)替加環(huán)素、阿米卡星的敏感率較高,分別為86%、66%。二、感染鮑曼不動(dòng)桿菌的HAP危險(xiǎn)因素的分析多變量回歸分析,感染前30天內(nèi)入住ICU(OR=85.588,95%CI,4.408~1661.943;P= 0.003)、感染前 30 天內(nèi)機(jī)械通氣(OR=34.502,95%CI,1.024~1161.992;P= 0.048)、感染前30天內(nèi)使用碳青霉烯類(lèi)抗生素(OR=12.065,95%CI,2.041~877.223;P=0.015)為感染鮑曼不動(dòng)桿菌的醫(yī)院獲得性肺炎獨(dú)立危險(xiǎn)因素。三、醫(yī)院獲得性肺炎預(yù)后危險(xiǎn)因素分析多變量回歸分析,感染時(shí)APACHE Ⅱ評(píng)分18(OR=29.520,95%CI 6.268~139.034;P=0.000)、合并 ARDS(OR=8.968,95%CI 1.586~50.709;P=0.013)、合并休克(OR=10.046,95%CI 1.275~79.163;P=0.028)是醫(yī)院獲得性肺炎患者預(yù)后的獨(dú)立危險(xiǎn)因素。感染鮑曼不動(dòng)桿的HAP患者30天的生存率小于非鮑曼不動(dòng)桿菌感染者(p=0.047)。結(jié)論:感染前30天內(nèi)入住ICU、機(jī)械通氣、使用碳青霉烯類(lèi)抗生素為感染鮑曼不動(dòng)桿菌的醫(yī)院獲得性肺炎獨(dú)立危險(xiǎn)因素。感染時(shí)APACHEⅡ評(píng)分18、合并ARDS、合并休克是醫(yī)院獲得性肺炎患者死亡的獨(dú)立危險(xiǎn)因素。而感染鮑曼不動(dòng)桿菌的HAP患者30天的生存率小于非鮑曼不動(dòng)桿菌感染者。
[Abstract]:Objective: to retrospectively analyze the risk factors of nosocomial pneumonia (HAP) in patients with Acinetobacter baumannii (AB) and the prognosis of patients with nosocomial pneumonia. To provide evidence for the prevention and treatment of nosocomial pneumonia, especially Acinetobacter baumannii infection. Methods: (HAP) patients with nosocomial pneumonia from January 2014 to December 2015 were divided into Acinetobacter baumannii HAP patients and non-Acinetobacter baumannii HAP patients according to sputum culture results. Risk factors of Acinetobacter baumannii infection in HAP patients and prognosis of HAP patients were analyzed. Medical records, sputum culture, laboratory and imaging findings were reviewed and the severity of the disease was evaluated by APACHE 鈪,
本文編號(hào):2390518
[Abstract]:Objective: to retrospectively analyze the risk factors of nosocomial pneumonia (HAP) in patients with Acinetobacter baumannii (AB) and the prognosis of patients with nosocomial pneumonia. To provide evidence for the prevention and treatment of nosocomial pneumonia, especially Acinetobacter baumannii infection. Methods: (HAP) patients with nosocomial pneumonia from January 2014 to December 2015 were divided into Acinetobacter baumannii HAP patients and non-Acinetobacter baumannii HAP patients according to sputum culture results. Risk factors of Acinetobacter baumannii infection in HAP patients and prognosis of HAP patients were analyzed. Medical records, sputum culture, laboratory and imaging findings were reviewed and the severity of the disease was evaluated by APACHE 鈪,
本文編號(hào):2390518
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