【摘要】：目的通過(guò)比較COPD組與非COPD組;COPD輕、中度組與重、極重度組；肺心功能代償組與肺心功能失代償組之間的血清生長(zhǎng)激素、睪酮水平有無(wú)差異,探討AECOPD患者血清生長(zhǎng)激素、睪酮的表達(dá)特征及其與病情的相關(guān)性,為進(jìn)一步的激素干預(yù)治療提供理論及實(shí)驗(yàn)依據(jù),從而改善COPD患者的癥狀,減緩病程的發(fā)展,提高生活質(zhì)量,減輕社會(huì)及經(jīng)濟(jì)負(fù)擔(dān)。 方法隨機(jī)選取2011年10月-2012年10月入院的慢性阻塞性肺疾病男性患者為COPD組,根據(jù)肺功能結(jié)果分為輕、中度組和重、極重度組；重、極重度組再分為肺心功能代償組和肺心功能失代償組。隨機(jī)選取同期入院的非COPD男性患者為非COPD組。COPD組和非COPD組均排除合并有肝腎功能衰竭、腫瘤、肺結(jié)核、糖尿病、結(jié)締組織病、甲狀腺疾病等慢性消耗性疾病,且近3月內(nèi)未接受激素治療及營(yíng)養(yǎng)支持治療。因正常情況下生長(zhǎng)激素呈脈沖分泌,血中半衰期短,夜間睡眠狀態(tài)下分泌明顯增加,所以本實(shí)驗(yàn)于入院當(dāng)天夜間0點(diǎn)抽取受試者空腹靜脈血；血清睪酮水平受性別影響較大,男性比女性有更高的血清睪酮水平,生長(zhǎng)激素也受性別影響,所以本研究均以男性為研究對(duì)象,以便于比較。生長(zhǎng)激素和睪酮均采用化學(xué)發(fā)光法檢測(cè)。同步抽取外周動(dòng)脈血作血?dú)夥治觯籆OPD組患者于病情穩(wěn)定后作肺功能檢查。 統(tǒng)計(jì)學(xué)處理應(yīng)用SPSS16.0統(tǒng)計(jì)分析軟件進(jìn)行數(shù)據(jù)分析。以完全隨即設(shè)計(jì)的兩樣本比較的t檢驗(yàn)比較COPD組與非COPD組;COPD輕、中度組與重、極重度組；肺心功能代償組與肺心功能失代償組之間的年齡、生長(zhǎng)激素及睪酮水平。 結(jié)果1.各組患者之間的年齡相比較,差別無(wú)統(tǒng)計(jì)學(xué)意義。 2. COPD組與非COPD組的血清生長(zhǎng)激素、睪酮水平相比較,差別均有統(tǒng)計(jì)學(xué)意義(P0.01)。 3. COPD輕、中度組與COPD重、極重度組的血清生長(zhǎng)激素、睪酮水平相比較,差別均有統(tǒng)計(jì)學(xué)意義(P0.05)。 4. COPD肺心功能代償組與COPD肺心功能失代償組的血清生長(zhǎng)激素和睪酮水平相比較,差別均有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論1、COPD組的血清生長(zhǎng)激素、睪酮水平明顯低于非COPD組。 2、COPD重、極重度組的血清生長(zhǎng)激素、睪酮水平低于COPD輕、中度組。 3、COPD肺心功能失代償組的血清生長(zhǎng)激素、睪酮水平低于COPD肺心功能代償組。 4、隨著病情的加重或嚴(yán)重并發(fā)癥的出現(xiàn),COPD患者血清生長(zhǎng)激素、睪酮水平呈逐漸下降趨勢(shì)。
[Abstract]:Objective to compare COPD group with non-COPD group, COPD mild group, moderate group and severe group. There were differences in serum growth hormone and testosterone levels between the lung heart function compensation group and the lung heart function decompensation group. The expression characteristics of serum growth hormone and testosterone in AECOPD patients and their correlation with the disease were investigated. To provide theoretical and experimental basis for further hormone intervention therapy, so as to improve the symptoms of patients with COPD, slow down the development of the course of disease, improve the quality of life, and reduce the social and economic burden. Methods male patients with chronic obstructive pulmonary disease (COPD) admitted from October 2011 to October 2012 were randomly selected as COPD group. According to the results of pulmonary function, they were divided into mild, moderate, severe and severe groups. The severe and severe groups were divided into two groups: lung heart function compensation group and lung heart function decompensation group. Non COPD male patients admitted in the same period were randomly selected as non COPD group. COPD group and non COPD group were excluded from chronic consumptive diseases such as liver and kidney failure, tumor, tuberculosis, diabetes, connective tissue disease, thyroid disease, etc. No hormone therapy and nutritional support therapy were received in the last three months. Under normal conditions, growth hormone was secreted by pulse, the half-life of blood was short, and the secretion of growth hormone was obviously increased during nighttime sleep, so the fasting venous blood was taken from the subjects at 0 o'clock at night on the day of admission. The serum testosterone level was significantly affected by sex, the male had higher serum testosterone level than the female, and the growth hormone was also affected by sex. Growth hormone and testosterone were detected by chemiluminescence. Peripheral arterial blood was extracted simultaneously for blood gas analysis, and pulmonary function was examined after stable condition in COPD group. Statistical analysis was carried out with SPSS16.0 software. T test was used to compare the age, growth hormone and testosterone levels between the COPD group and the non COPD group, the mild, moderate and severe groups of COPD, the lung heart function compensation group and the lung heart function decompensation group. Result 1. There was no significant difference in age between each group. 2. The serum levels of growth hormone and testosterone in COPD group and non-COPD group were significantly different (P0.01). 3. The serum levels of growth hormone and testosterone in the mild and moderate COPD group were significantly different from those in the severe COPD group and the very severe group (P0.05). 4. The serum levels of growth hormone and testosterone in COPD group and COPD group were significantly higher than those in COPD group (P0.05). Conclusion 1 the serum levels of growth hormone and testosterone in COPD group were significantly lower than those in non COPD group. 2 the serum levels of growth hormone and testosterone in the severe and severe COPD group were lower than those in the mild and moderate COPD group. 3 the serum levels of growth hormone and testosterone in COPD group were lower than those in COPD group. 4. The serum levels of growth hormone and testosterone in patients with COPD decreased gradually with the exacerbation of the disease or the appearance of severe complications.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R563

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李娟,劉勃,沈興平;糖皮質(zhì)激素治療對(duì)COPD患者血清性激素變化的影響[J];重慶醫(yī)學(xué);2002年11期

2 趙振波;陳昌枝;;COPD患者甲狀腺功能變化的初步探討[J];廣西醫(yī)學(xué);2010年11期

3 徐愛(ài)暉;老年COPD患者慢性缺氧與性激素的關(guān)系[J];疾病控制雜志;2002年02期

4 陳昌枝;覃家盟;邵有和;吳文彬;;AECOPD甲狀腺功能變化及與肺功能的關(guān)系[J];臨床肺科雜志;2012年04期

5 李軍,劉立,許玲華;基因重組生長(zhǎng)激素在COPD急性加重期的治療[J];臨床肺科雜志;2004年02期

6 李蘋(píng);;生長(zhǎng)激素加營(yíng)養(yǎng)支持對(duì)COPD發(fā)作期病人營(yíng)養(yǎng)及免疫功能的影響[J];齊齊哈爾醫(yī)學(xué)院學(xué)報(bào);2007年16期

7 楊連秀;秦吉祥;齊慧生;范雪靜;;rHGH在COPD并呼吸衰竭行機(jī)械通氣及空腸營(yíng)養(yǎng)患者中的應(yīng)用[J];山東醫(yī)藥;2007年29期

8 龍怡,吳粵,曾紅科;生長(zhǎng)激素在COPD機(jī)械通氣治療中的臨床應(yīng)用[J];實(shí)用醫(yī)學(xué)雜志;2005年15期

9 譽(yù)鐵鷗;周立新;黎文研;鄒毅成;;腸內(nèi)營(yíng)養(yǎng)聯(lián)合生長(zhǎng)激素在ICU重癥COPD并呼吸衰竭機(jī)械通氣患者撤機(jī)過(guò)程中的應(yīng)用[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2010年14期

10 雷卓青,唐秀光,黃小琳,黃蔚,陳暉;老年慢性阻塞性肺疾病患者營(yíng)養(yǎng)狀態(tài)與血清瘦素、生長(zhǎng)激素的相關(guān)性[J];中國(guó)臨床康復(fù);2003年21期

，

本文編號(hào)：2365412