發(fā)布時(shí)間：2018-11-02 09:41

【摘要】：目的研究血清MMP-7在IPF患者中的變化,探討其在肺纖維化患者發(fā)病中的作用。方法收集11例IPF患者血清為實(shí)驗(yàn)組,收集10例健康成人血清為對照組。采用酶聯(lián)免疫吸附法(ELISA)測定血清MMP-7含量,并與肺功能、動(dòng)脈血?dú)夥治�、呼吸困難程度進(jìn)行分析。結(jié)果①IPF患者肺功能輕中度組血清MMP-7濃度(41.54±10.11)ng/mL及肺功能重度組血清MMP-7濃度(61.42±10.96)ng/mL,高于正常對照組血清MMP-7濃度(26.57±15.89)ng/mL,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。肺功能重度組血清MMP-7濃度高于肺功能輕中度組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。②IPF患者血清MMP-7水平與動(dòng)脈PaO2呈負(fù)相關(guān)(rs=-0.623,P=0.041),與呼吸困難嚴(yán)重程度呈正相關(guān)(rs=0.684,P=0.02),而與P(A-a)O2、PaCO2及HCO3-濃度無明顯相關(guān)性(P0.05)。結(jié)論①M(fèi)MP-7可能參與了IPF的發(fā)病過程;②MMP-7可作為IPF嚴(yán)重程度及預(yù)后的一項(xiàng)參考指標(biāo)。
[Abstract]:Objective to study the changes of serum MMP-7 in patients with IPF and its role in the pathogenesis of pulmonary fibrosis. Methods Serum samples of 11 patients with IPF were collected as experimental group and 10 healthy adults as control group. The content of serum MMP-7 was determined by Elisa (ELISA), and was analyzed with pulmonary function, arterial blood gas analysis and degree of dyspnea. Results the serum MMP-7 concentration in patients with 1IPF was (41.54 鹵10.11) ng/mL and that in patients with severe pulmonary function was (61.42 鹵10.96) ng/mL,. The serum MMP-7 concentration was (26.57 鹵15.89) ng/mL, higher than that of the normal control group (P0.05). The serum MMP-7 concentration in severe pulmonary function group was significantly higher than that in mild to moderate pulmonary function group (P0.05). The serum MMP-7 level in 2IPF patients was negatively correlated with arterial PaO2 (rs=-0.623,P=0.041). There was a positive correlation with the severity of dyspnea (rs=0.684,P=0.02), but no significant correlation with the concentration of P (A-a) O _ 2 Paco _ 2 and HCO3- (P0.05). Conclusion 1MMP-7 may be involved in the pathogenesis of IPF and 2MMP-7 may be a reference index for the severity and prognosis of IPF.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院呼吸一科;
【基金】：遵義匯川區(qū)科技局基金資助項(xiàng)目(NO:209.001.122.09)
【分類號】：R563.9
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本文編號：2305661