【摘要】：[目的]1.研究炎癥反應(yīng)是否參與肺栓塞的發(fā)展。 2.討論瑞舒伐他汀對(duì)肺血栓栓塞癥是否有治療作用。 [方法]選取健康、雄性的Wistar大鼠45只,大鼠周齡為6-8,體重在180-220g之間,隨機(jī)分呈3組,每組15只大鼠,A組為對(duì)照組、B組為肺栓塞模型組,C組為實(shí)驗(yàn)組(經(jīng)瑞舒伐他汀干預(yù)的肺栓塞大鼠),實(shí)驗(yàn)前經(jīng)尾靜脈取血制備字體血栓,A、B組以生理鹽水灌胃3天,C組以5mg/kg*d瑞舒伐他汀灌胃3天,B、C組經(jīng)頸靜脈注射含栓子的生理鹽水2ml。24h后采三組大鼠血,每只大鼠取4毫升,通過(guò)雙抗體夾心法方法測(cè)定BNP及IL-6的濃度。 [結(jié)果]A組與B組、C組及B組之間NT-pro-BNP、IL-6值均有統(tǒng)計(jì)學(xué)差異(P0.05),A組的血漿NT-pro-BNP為(12.57±2.20)pg/L,B組血漿NT-pro-BNP為(42.14±4.52)pg/L,C組的血漿NT-pro-BNP為(21.03±1.98)pg/L；A組的血漿IL-6為(61.36±14.25)pg/L,B組血漿NT-pro-BNP為(92.54±12.85)pg/L,C組的血漿NT-pro-BNP為(70.31±14.20)pg/L,A組與B組、C組與B組之間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 [結(jié)論]1炎癥反應(yīng)參與了肺栓塞的發(fā)展。 2瑞舒伐他汀對(duì)肺栓塞有治療作用。
[Abstract]:[objective] 1. To study whether inflammatory response is involved in the development of pulmonary embolism. 2. To discuss the therapeutic effect of rosuvastatin on pulmonary thromboembolism. [methods] Forty-five healthy, male Wistar rats were randomly divided into 3 groups, aged 6-8 and weighing between 180-220 g. There were 15 rats in each group, A group as control group, B group as pulmonary embolism model group, C group as experimental group (pulmonary embolism rats treated by recuvastatin). The rats in group B were given 5mg/kg*d recuvastatin for 3 days, and rats in group C were injected with saline 2ml.24h containing embolus via jugular vein for 3 days. The concentrations of BNP and IL-6 were determined by double antibody sandwich method. [results] there was significant difference in NT-pro-BNP,IL-6 between group A and group B, group C and group B (P0.05 in), A group, plasma NT-pro-BNP was (12.57 鹵2.20) pg/L,B), plasma NT-pro-BNP was (42.14 鹵4.52) pg/L,C, plasma NT-pro-BNP was (21.03 鹵1.98) pg/L;. The plasma IL-6 of group A was (61.36 鹵14.25) pg/L,B, the plasma NT-pro-BNP of group A was (92.54 鹵12.85) pg/L,C, the plasma NT-pro-BNP of group A was (70.31 鹵14.20) pg/L,A and group B, the difference between group C and group B was statistically significant (P0.05). [conclusion] 1 inflammatory reaction is involved in the development of pulmonary embolism. 2 Risuvastatin has therapeutic effect on pulmonary embolism.
【學(xué)位授予單位】：濱州醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R563.5

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