慢性阻塞性肺疾病患者膈肌厚度分數(shù)與活動耐力和呼吸困難相關(guān)性研究
發(fā)布時間：2018-10-17 14:17
【摘要】：目的觀察慢性阻塞性肺疾病(慢阻肺)患者膈肌厚度變化,評價其與活動耐力和呼吸困難的關(guān)系。方法選取2015年8月至2016年8月上海市東方醫(yī)院呼吸門診收治的慢阻肺患者50例,同時選取該院職工肺功能正常的30名年齡與之接近的健康人作為對照組。分別行肺功能檢查,在功能殘氣(FRC)、肺總量(TLC)位超聲測量膈肌厚度(TD),計算膈肌厚度分數(shù)(TF,從FRC至TLC位膈肌厚度的變化),6 min步行距離(6MWT)、呼吸困難指數(shù)(m MRC);分析慢阻肺患者TD變化與肺功能和活動能力的相關(guān)性。結(jié)果慢阻肺組TLC位膈肌厚度和厚度分數(shù)分別為(0.38±0.10)cm和1.02±0.45,與健康對照組[(0.49±0.09)cm和(1.41±0.47)]比較差異有統(tǒng)計學(xué)意義(P0.05)。厚度分數(shù)與6MWT呈正相關(guān)(r=0.591,P0.01),與m MRC呈負相關(guān)(r=-0.472,P=0.001)。根據(jù)厚度分數(shù)水平,將慢阻肺組分為2亞組:G1(≤1.458),G2(1.458)。G1組6MWT為(371.95±95.73)m,較G2組[(512.00±108.61)m]降低(P0.05);G1組mMRC為2.63±1.08,較G2組(1.70±0.82)增高(P0.05);G1組氣道阻塞(FEV_1)為(47.41±16.70)L,最大自主通氣量(MVV)為(46.32±17.97)L,兩者較G2組[FEV_1為(69.96±16.82)L,MVV(62.60±22.13)L]下降(均P0.05)。結(jié)論慢阻肺患者膈肌厚度和厚度分數(shù)下降影響患者活動耐力和呼吸困難。
[Abstract]:Objective to observe the changes of diaphragm thickness in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the relationship between diaphragm thickness and activity tolerance and dyspnea. Methods from August 2015 to August 2016, 50 patients with chronic obstructive pulmonary disease (COPD) were selected from respiratory outpatient department of Shanghai Oriental Hospital, and 30 healthy people whose lung function were normal were selected as control group. Lung function tests were performed separately, Measurement of diaphragmatic thickness by ultrasound at total lung volume of (FRC), and (TD), (change of diaphragm thickness from FRC to TLC in TF,), 6 min walking distance (6MWT), (m MRC); analysis of TD and pulmonary function in COPD patients with dyspnea index (m MRC);) And the relevance of the activity ability. Results the diaphragm thickness and thickness fraction in TLC group were (0.38 鹵0.10) cm and (1.02 鹵0.45) cm, respectively, which were significantly different from those in healthy control group [(0.49 鹵0.09) cm and (1.41 鹵0.47)] (P0.05). The thickness fraction was positively correlated with 6MWT (r = 0.591, P 0.01) and negatively correlated with m MRC (r = 0.472P ~ (0.001). 鏍規(guī)嵁鍘氬害鍒嗘暟姘村鉤,灝嗘參闃昏偤緇勫垎涓，
本文編號：2276945
[Abstract]:Objective to observe the changes of diaphragm thickness in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the relationship between diaphragm thickness and activity tolerance and dyspnea. Methods from August 2015 to August 2016, 50 patients with chronic obstructive pulmonary disease (COPD) were selected from respiratory outpatient department of Shanghai Oriental Hospital, and 30 healthy people whose lung function were normal were selected as control group. Lung function tests were performed separately, Measurement of diaphragmatic thickness by ultrasound at total lung volume of (FRC), and (TD), (change of diaphragm thickness from FRC to TLC in TF,), 6 min walking distance (6MWT), (m MRC); analysis of TD and pulmonary function in COPD patients with dyspnea index (m MRC);) And the relevance of the activity ability. Results the diaphragm thickness and thickness fraction in TLC group were (0.38 鹵0.10) cm and (1.02 鹵0.45) cm, respectively, which were significantly different from those in healthy control group [(0.49 鹵0.09) cm and (1.41 鹵0.47)] (P0.05). The thickness fraction was positively correlated with 6MWT (r = 0.591, P 0.01) and negatively correlated with m MRC (r = 0.472P ~ (0.001). 鏍規(guī)嵁鍘氬害鍒嗘暟姘村鉤,灝嗘參闃昏偤緇勫垎涓，
本文編號：2276945
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