【摘要】：目的檢測2型糖尿病(T2DM)伴阻塞性睡眠呼吸暫停(OSA)患者體內(nèi)蛋白質(zhì)羰基(PCO)含量,評價(jià)合并OSA是否加重T2DM患者的蛋白氧化損傷。方法根據(jù)是否合并OSA將T2DM患者分為單純T2DM組(DM組46例),T2DM合并OSA患者組(DO組39例),設(shè)立正常對照組(NC組40例),測定血清PCO含量。結(jié)果各組性別、年齡、體重指數(shù)(BMI)、腰臀比(WHR)的差別無統(tǒng)計(jì)學(xué)差異(P0.05)。DM、DO組血PCO水平較NC組明顯升高(P0.01),DO組血PCO水平較NC組、DM組明顯升高(P0.05)。結(jié)論 T2DM患者體內(nèi)存在蛋白質(zhì)氧化損傷,合并OSA加重T2DM患者體內(nèi)的蛋白質(zhì)氧化損傷。
[Abstract]:Objective to determine the content of protein carbonyl (PCO) in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA), and to evaluate whether the protein oxidative damage in patients with T2DM is aggravated by OSA. Methods patients with T2DM were divided into T2DM group (DM group, 46 cases) and T2DM with OSA group (DO group, 39 cases), and normal control group (NC group, 40 cases). The serum PCO content was measured. Results there was no significant difference in sex, age, body mass index (BMI),) and waist hip ratio (WHR) among the three groups (P0.05). The serum PCO level in the DMN do group was significantly higher than that in the NC group (P0.01). The serum PCO level in the do group was significantly higher than that in the NC group (P0.05). Conclusion oxidative damage of protein exists in patients with T2DM, and it is aggravated by OSA in patients with T2DM.
【作者單位】： 威海市立醫(yī)院內(nèi)分泌科;
【基金】：威海市科技局資助項(xiàng)目(2013)
【分類號】：R587.1;R56

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 Patel DK;Kumar R;Laloo D;Hemalatha S;;Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity[J];Asian Pacific Journal of Tropical Biomedicine;2012年05期

2 李一梅;劉寬芝;;氧化應(yīng)激、線粒體功能障礙與2型糖尿病[J];臨床薈萃;2014年02期

3 任春久;張瑤;崔為正;牟志美;;氧化應(yīng)激在2型糖尿病發(fā)病機(jī)制中的作用研究進(jìn)展[J];生理學(xué)報(bào);2013年06期

相關(guān)博士學(xué)位論文 前2條

1 王霞;核因子E2相關(guān)因子2基因多態(tài)性與氧化應(yīng)激及2型糖尿病易感性的關(guān)聯(lián)研究[D];華中科技大學(xué);2013年

2 黎黎;替米沙坦激活過氧化物酶體增殖物活化受體δ改善小鼠胰島素抵抗及其機(jī)制研究[D];第三軍醫(yī)大學(xué);2013年

相關(guān)碩士學(xué)位論文 前10條

1 聶倩;Mfn2對棕櫚酸誘導(dǎo)的大鼠骨骼肌細(xì)胞氧化應(yīng)激與胰島素抵抗的影響[D];河北醫(yī)科大學(xué);2013年

2 林雪t，

本文編號：2257631