【摘要】：目的觀察胸腺法新對社區(qū)獲得性重癥肺炎老年患者體內(nèi)T淋巴細(xì)胞亞群和體液免疫球蛋白水平的影響。方法將61例ICU社區(qū)獲得性重癥肺炎老年患者隨機(jī)分為兩組,對照組入院后予經(jīng)口氣管插管接呼吸機(jī)輔助通氣并先按經(jīng)驗(yàn)予抗感染等對癥支持治療,然后根據(jù)細(xì)菌培養(yǎng)結(jié)果調(diào)整抗生素使用;觀察組在常規(guī)治療基礎(chǔ)上使用胸腺法新1.6 mg皮下注射,2次/d,治療1周。比較兩組患者體內(nèi)T淋巴細(xì)胞亞群、免疫球蛋白和臨床轉(zhuǎn)歸。結(jié)果觀察組患者體內(nèi)CD4+T淋巴細(xì)胞亞群比例高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者血清補(bǔ)體C3、C4、IgG、IgM、IgA免疫球蛋白水平及臨床療效比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論胸腺法新可以提高體內(nèi)CD4+T淋巴細(xì)胞亞群比例。
[Abstract]:Objective to observe the effect of thymus on T lymphocyte subsets and humoral immunoglobulin levels in elderly patients with community acquired severe pneumonia. Methods Sixty-one elderly patients with ICU community-acquired severe pneumonia were randomly divided into two groups. The control group was treated with tracheal intubation and ventilator assisted ventilation after admission. Then the antibiotics were adjusted according to the results of bacterial culture, and the observation group was treated with thymus 1. 6 mg subcutaneous injection twice a day for 1 week. T lymphocyte subsets, immunoglobulin and clinical outcome were compared between the two groups. Results the percentage of CD4 T lymphocyte subsets in patients in the observation group was higher than that in the control group (P0.05), and there was no significant difference between the two groups (P0.05). Conclusion thymus assay can increase the proportion of CD4 T lymphocyte subsets in vivo.
【作者單位】： 廣東省汕頭市中心醫(yī)院ICU;廣東省汕頭市中心醫(yī)院感染科;廣東省汕頭市中心醫(yī)院呼吸科;
【分類號】：R563.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 方怡,冉丕鑫;重癥社區(qū)獲得性肺炎炎性機(jī)制研究進(jìn)展[J];國外醫(yī)學(xué).呼吸系統(tǒng)分冊;2005年01期

2 劉建;黃芪;金常娥;劉曉晴;;老年肺炎患者免疫功能失常的初步探討[J];內(nèi)科急危重癥雜志;2007年02期

3 陸衛(wèi)東;殷少軍;祝煒;李瑾;李微;樊美紅;張毅琴;林樺;董福輪;;老年反復(fù)呼吸道感染患者T淋巴細(xì)胞亞群變化及胸腺肽α_1干預(yù)研究[J];實(shí)用藥物與臨床;2012年08期

4 侯立朝;熊利澤;尚磊;霍婷婷;陳紹洋;胡文能;王雅麗;;胸腺肽α_1對重癥肺部感染患者T淋巴細(xì)胞亞群比例的影響[J];中華麻醉學(xué)雜志;2006年11期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張緒新;剛麗;張新莉;;老年難治性肺炎成因及臨床治療[J];大連大學(xué)學(xué)報(bào);2009年03期

2 武焱e，

本文編號：2223770