【摘要】：目的：觀察二陳湯加味對(duì)COPD急性加重期(痰濁阻肺證)患者的臨床癥狀及肺功能的影響,客觀評(píng)估其臨床療效。方法：選取COPD急性加重期患者60例,西醫(yī)嚴(yán)重程度分級(jí)為Ⅰ～Ⅲ級(jí),同時(shí)中醫(yī)辨證為痰濁阻肺證,以隨機(jī)分配方式分成治療組及對(duì)照組各30例。對(duì)照組給予單純西醫(yī)治療,治療組在常規(guī)西醫(yī)治療基礎(chǔ)上聯(lián)合二陳湯加味,療程共為14天,觀察患者治療前后肺功能、臨床癥狀、體征的變化。結(jié)果：1、二陳湯加味治療COPD急性加重期(痰濁阻肺證)的患者可明顯改善患者的臨床癥狀,治療組總有效率96.67%,對(duì)照組總有效率83.33%,兩者比較有統(tǒng)計(jì)學(xué)意義(P0.05),治療組的療效優(yōu)于對(duì)照組。治療組在主癥胸滿、咳嗽、痰多、色白黏膩或呈泡沫、短氣、喘息及兼次癥脘痞、納少、倦怠乏力等方面改善明顯優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)；兩組在兼次癥畏風(fēng)易汗、泛惡、便溏方面的改善無(wú)明顯差異(P0.05)。2、兩組患者肺功能指標(biāo)FEV1%pred、FEV1/FCV%較治療前均有所改善(P0.05)；且治療組在治療后FEV1%pred、FEV1/FCV%改善方面優(yōu)于對(duì)照組,有統(tǒng)計(jì)學(xué)意義(P0.05)。3、治療后,兩組患者血細(xì)胞分析、尿液常規(guī)分析、便常規(guī)、肝功能、腎功能、心電圖等安全性指標(biāo)無(wú)異常,且患者均未出現(xiàn)明顯不適反應(yīng)。結(jié)論：1、二陳湯加味可明顯改善COPD急性加重期(痰濁阻肺證)患者的臨床癥狀；2、二陳湯加味可改善COPD急性加重期(痰濁阻肺證)患者肺通氣功能；3、二陳湯加味治療COPD急性加重期(痰濁阻肺證)患者的治療過程中無(wú)明顯毒副作用及不良反應(yīng)。
[Abstract]:Objective: to observe the effect of Erchen decoction on the clinical symptoms and pulmonary function of patients with acute exacerbation of COPD. Methods: 60 patients with acute exacerbation of COPD were divided into treatment group (n = 30) and control group (n = 30). The control group was treated with simple western medicine, and the treatment group was treated with Erchen decoction on the basis of routine western medicine. The course of treatment was 14 days. The changes of pulmonary function, clinical symptoms and signs were observed before and after treatment. Results the clinical symptoms of the patients with acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome) could be improved obviously by adding Wei 1 and Erchen Tang. The total effective rate of the treatment group was 96.677.The total effective rate of the control group was 83.33.The comparison between the two groups was statistically significant (P0.05). The curative effect of the treatment group was better than that of the control group. The treatment group was significantly better than the control group in chest filling, cough, phlegm, color, white, sticky or foam, shortness of breath, wheezing and chronic epigastric distension, less intake and fatigue, etc. The difference was statistically significant (P0.05). There was no significant difference in the improvement of loose stools (P0.05). The pulmonary function index (FEV1%pred,FEV1/FCV%) was improved in the two groups (P0.05), and the improvement of FEV1%pred,FEV1/FCV% in the treatment group was better than that in the control group (P0.05) .3.After the treatment, the two groups had blood cell analysis. The routine analysis of urine showed that there were no abnormal safety indexes such as stool routine, liver function, renal function and electrocardiogram, and no obvious discomfort was found in the patients. Conclusion the clinical symptoms of patients with acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome) can be obviously improved by adding Wei 1 and er Chen Tang, and the pulmonary ventilation function of patients with acute exacerbation of COPD (phlegm turbid obstruction of lung) can be improved by Erchen decoction. There were no obvious side effects and side effects during the treatment of acute exacerbation of COPD (phlegm turbid obstruction of lung syndrome).
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R563.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 徐雯潔;王天芳;王智瑜;于麗麗;呂佳蒼;王慶國(guó);;基于現(xiàn)代文獻(xiàn)的慢性阻塞性肺疾病中醫(yī)證候及證候要素的研究[J];中華中醫(yī)藥雜志;2008年01期

2 王至婉;李建生;余學(xué)慶;李素云;鄭四平;孫子凱;張偉;賈新華;王明航;王海峰;;慢性阻塞性肺疾病急性加重期證候及特征的臨床調(diào)查研究[J];中華中醫(yī)藥雜志;2010年04期

3 鄭豐杰;李宇航;鐘相根;孫燕;張鵬;張歡;;慢性阻塞性肺疾病中醫(yī)病機(jī)特點(diǎn)及“從腸論治”的理論探討[J];中華中醫(yī)藥雜志;2010年12期

4 朱淵紅;氧化/抗氧化失衡與慢性阻塞性肺疾病[J];國(guó)外醫(yī)學(xué)(呼吸系統(tǒng)分冊(cè));2003年01期

5 田正鑒,徐幼明,李亞清;慢性阻塞性肺疾病中醫(yī)病機(jī)探微[J];湖北中醫(yī)學(xué)院學(xué)報(bào);2001年01期

6 張?jiān)?洪廣祥;“肺與大腸相表里”理論在慢性阻塞性肺疾病急性發(fā)作期的應(yīng)用[J];江西中醫(yī)藥;2000年03期

7 鄭潔,洪廣祥;“治肺不遠(yuǎn)溫”在慢性阻塞性肺疾病(COPD)急性發(fā)作期的臨床研究[J];江西中醫(yī)藥;2000年06期

8 陳憲海;崔榮珍;劉兆恩;;慢性阻塞性肺疾病穩(wěn)定期中醫(yī)病機(jī)述要[J];遼寧中醫(yī)雜志;2006年01期

9 溫敏勇;孫志佳;;肺脾腎三臟分治法辨治慢性阻塞性肺疾病[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2010年09期

10 彭波;李澤庚;童佳兵;楊程;王傳博;張念志;;慢性阻塞性肺疾病中醫(yī)藥研究進(jìn)展[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2011年06期

，

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