【摘要】：目的探究呼吸機相關性肺炎(VAP)并發(fā)單一假絲酵母菌感染患者的臨床特征以及與降鈣素原(PCT)、白細胞介素-6(IL-6)和C-反應蛋白(CRP)等炎癥指標的相關性。方法選擇2008年1月-2016年3月醫(yī)院收治的149例VAP患者,根據(jù)假絲酵母菌感染的相關診斷標準,分為假絲酵母菌屬組65例、其他病菌組84例;比較兩組患者臨床指標。結(jié)果在65例伴有假絲酵母菌感染的VAP患者中,以白假絲酵母菌感染為主,共40株占61.54%;在假絲酵母菌屬組中,β-葡聚糖陽性患者的PCT、IL-6以及CRP水平均顯著高于β-葡聚糖陰性患者,組間比較差異有統(tǒng)計學意義(P0.05)。結(jié)論導致VAP患者發(fā)生的假絲酵母菌感染的易感因素眾多,在臨床治療期間需積極消除各種易感因素,及時給予其相應的抗真菌感染治療;β-葡聚糖在評價假絲酵母菌感染以及感染程度上具有一定的臨床應用價值。
[Abstract]:Objective to investigate the clinical features of patients with ventilator-associated pneumonia (VAP) complicated with single Candida cerevisiae infection and its correlation with procalcitonin (PCT), interleukin-6 (IL-6) and C-reactive protein (CRP). Methods 149 patients with VAP from January 2008 to March 2016 were divided into Candida group (n = 65) and other bacteria group (n = 84) according to the diagnostic criteria of Candida infection. Results among 65 VAP patients with Candida cerevisiae infection, 40 strains were Candida albicans infection (61.54%), and the levels of PCT,IL-6 and CRP in Candida group were significantly higher than those in 尾 -glucan negative group. The difference between groups was statistically significant (P0.05). Conclusion there are many susceptible factors of Candida cerevisiae infection in patients with VAP. 尾-glucan has certain clinical value in evaluating Candida candida infection and the degree of infection.
【作者單位】： 南陽市第二人民醫(yī)院呼吸內(nèi)科;南陽醫(yī)專一附院骨科;南陽醫(yī)專一附院重癥醫(yī)學科;
【基金】：河南省科技攻關基金資助項目(971200100)
【分類號】：R563.1

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