【摘要】：目的系統(tǒng)評(píng)價(jià)比阿培南治療呼吸系統(tǒng)和泌尿系統(tǒng)細(xì)菌性感染的臨床療效和安全性。方法通過(guò)PubMed數(shù)據(jù)庫(kù)、ELSEVIER數(shù)據(jù)庫(kù)、相關(guān)期刊論文、萬(wàn)方數(shù)據(jù)庫(kù),檢索比阿培南治療呼吸系統(tǒng)和泌尿系統(tǒng)細(xì)菌性感染的臨床隨機(jī)對(duì)照試驗(yàn)文獻(xiàn),采用Rev Man 5.1版統(tǒng)計(jì)分析軟件進(jìn)行Meta分析,采用GRADE profiler 3.6版軟件對(duì)證據(jù)質(zhì)量進(jìn)行評(píng)價(jià)分級(jí)。結(jié)果共有9篇文獻(xiàn)符合納入標(biāo)準(zhǔn),全部文獻(xiàn)共有患者1 397例,在總有效率[RR=1.04,95%CI(0.98,1.10),P=0.19]、細(xì)菌清除率[RR=1.02,95%CI(0.97,1.07),P=0.39]、呼吸系統(tǒng)細(xì)菌性感染有效率[RR=1.04,95%CI(0.97,1.11),P=0.26]、泌尿系統(tǒng)細(xì)菌性感染有效率[RR=0.98,95%CI(0.88,1.09),P=0.74]、總不良反應(yīng)發(fā)生率[RR=0.83,95%CI(0.60,1.15),P=0.26]及各不良反應(yīng)發(fā)生率方面,治療組(比阿培南)與對(duì)照組(亞胺培南/西司他丁鈉、美羅培南或其他碳青霉烯類(lèi)抗菌藥物)均差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。GRADE系統(tǒng)評(píng)價(jià)結(jié)果顯示,總不良反應(yīng)發(fā)生率和各不良反應(yīng)發(fā)生率的證據(jù)水平為中等,其余各結(jié)局指標(biāo)均為低級(jí)。結(jié)論基于當(dāng)前的臨床證據(jù),比阿培南治療各種敏感菌所引起的呼吸系統(tǒng)和泌尿系統(tǒng)細(xì)菌性感染的有效性和安全性與美羅培南和亞胺培南/西司他丁相當(dāng)。
[Abstract]:Objective to evaluate the efficacy and safety of Biapenem in the treatment of bacterial infections of respiratory and urinary systems. Methods the clinical randomized controlled trials of Biapenem in the treatment of bacterial infection of respiratory system and urinary system were searched by PubMed database, Chinese periodical full-text database and Wanfang database. The statistical analysis software of Rev Man 5.1 was used for Meta analysis, and the software GRADE profiler 3.6 was used to evaluate the quality of evidence. Results A total of 9 articles met the inclusion criteria, and 1,397 patients were included in all the literature. The total effective rate [RRN 1.04C _ (95) CI (0.981.10) P _ (0.19)], the bacterial clearance rate [RRN _ 1.02C _ (95) CI (0.971.07) P _ (0.39)], the effective rate of respiratory bacterial infection [(R _ (1.04) ~ (95) CI (0.971.11) P _ (0.26)], the effective rate of urinary system infection [RRN _ (0.9895) CI (0.88 鹵1.09) P _ (0.74)], the incidence of total adverse reactions [RR0.83C _ (95) CI (0.601.15)] and the incidence of adverse reactions were observed. There was no significant difference between the treatment group (Biapenem) and the control group (imipenem / cilastatin sodium, meropenem or other carbapenem antibiotics) (P0.05). The incidence of total adverse reactions and the incidence of adverse reactions were moderate, and the other outcome indicators were low. Conclusion based on current clinical evidence, Biapenem is as effective and safe as meropenem and imipenem / cilastatin in the treatment of bacterial infections of respiratory and urinary systems caused by various sensitive bacteria.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院藥學(xué)部;
【分類(lèi)號(hào)】：R56;R691.3

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