發(fā)布時間：2018-08-03 21:29

【摘要】：目的觀察川芎嗪注射液聯(lián)合阿奇霉素序貫治療大葉性肺炎及遷延性肺炎的臨床療效及安全性。方法 68例大葉性肺炎及遷延性肺炎患者隨機(jī)分為對照組34例與試驗組34例。對照組在常規(guī)治療的基礎(chǔ)上靜脈滴注注射用阿奇霉素10 mg·kg~(-1),連用3~5 d,患者體溫及外周血白細(xì)胞恢復(fù)至正常范圍,口服阿奇霉素干混懸劑10 mg·kg~(-1),每日1次。試驗組在對照組的基礎(chǔ)上靜脈滴注鹽酸川芎嗪注射液40 mg,每日1次。2組患者均治療10 d。比較2組的臨床療效、血清白細(xì)胞介素-6(IL-6)、白細(xì)胞介素-8(IL-8)、白細(xì)胞介素-10(IL-10)、T淋巴細(xì)胞亞群水平及藥物不良反應(yīng)發(fā)生情況。結(jié)果治療后,試驗組總有效率為88.24%(30/34例),對照組為64.71%(22/34例,P0.05)。治療后,對照組和試驗組IL-6分別為(40.39±4.87),(21.08±2.90)pg·mL~(-1);IL-8分別為(43.29±5.22),(27.93±3.19)pg·mL~(-1),IL-10分別為(31.93±3.53),(18.02±2.45)pg·mL~(-1),差異有統(tǒng)計學(xué)意義(P0.05)。治療后,對照組和試驗組CD3+分別為(63.49±7.41)%,(77.92±8.41)%,CD4~+分別為(30.20±3.58)%,(35.83±4.71)%,CD8~+分別為(27.38±3.49)%,(23.07±3.01)%,CD4~+/CD8~+分別為1.18±0.21,1.32±0.16,差異均有統(tǒng)計學(xué)意義(均P0.05)。試驗組的藥物不良反應(yīng)有胸悶、輕微胃腸道反應(yīng)、低血壓,藥物不良反應(yīng)發(fā)生率為8.82%(3/34例);對照組的藥物不良反應(yīng)有嗜睡、輕微胃腸道反應(yīng)、胸悶、皮疹,藥物不良反應(yīng)發(fā)生率為17.65%(6/34例),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論川芎嗪注射液聯(lián)合阿奇霉素序貫治療大葉性肺炎及遷延性肺炎的臨床療效較高,安全性高。
[Abstract]:Objective to observe the clinical efficacy and safety of ligustrazine injection combined with azithromycin in the treatment of lobar pneumonia and persistent pneumonia. Methods 68 patients with lobar pneumonia and persistent pneumonia were randomly divided into control group (34 cases) and trial group (34 cases). On the basis of routine treatment, the patients in the control group were treated with azithromycin 10 mg kg ~ (-1) intravenously for 5 days, and the body temperature and peripheral blood leukocytes returned to normal level. The patients were given azithromycin dry suspension 10 mg kg ~ (-1) once a day. In the experimental group, 40 mg of ligustrazine hydrochloride was injected intravenously on the basis of the control group, and the patients in group 2 were treated for 10 days once a day. The clinical efficacy, serum interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) T lymphocyte subsets and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate was 88.24% (30 / 34 cases) in the trial group and 64.71% (22 / 34 cases) in the control group (P0.05). After treatment, the IL-6 of the control group and the experimental group were (40.39 鹵4.87), (21.08 鹵2.90) PG mL ~ (-1) and (43.29 鹵5.22), (27.93 鹵3.19) PG mL ~ (-1) IL-10, respectively (31.93 鹵3.53), (18.02 鹵2.45) PG mL ~ (-1) (P0.05). After treatment, the CD3 of the control group and the experimental group were (63.49 鹵7.41), (77.92 鹵8.41) and (30.20 鹵3.58), (35.83 鹵4.71) and (27.38 鹵3.49), respectively (63.49 鹵7.41), (77.92 鹵8.41) and (30.20 鹵3.58), (35.83 鹵4.71), (27.38 鹵3.49) and (23.07 鹵3.01), respectively. The adverse drug reactions in the trial group were chest tightness, mild gastrointestinal reaction, hypotension, adverse drug reaction rate of 8.82% (3 / 34 cases), and the adverse drug reactions in the control group were somnolence, mild gastrointestinal reaction, chest tightness, rash. The incidence of adverse drug reactions was 17.65% (6 / 34 cases) with no significant difference (P0.05). Conclusion Ligustrazine injection combined with azithromycin is safe and effective in the treatment of lobar pneumonia and persistent pneumonia.
【作者單位】： 紹興市立醫(yī)院呼吸一科;
【基金】：浙江省醫(yī)藥衛(wèi)生一般研究計劃基金資助項目(2013KYA209)
【分類號】：R563.1

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