【摘要】：目的探討血必凈注射液對重癥肺炎患者血漿中白細胞介素-6(IL-6)和腫瘤壞死因子-α(TNF-α)的影響。方法將100例重癥肺炎患者按隨機數(shù)字表法分為對照組(50例)和治療組(50例)。兩組均給予常規(guī)西醫(yī)治療,治療組在常規(guī)西醫(yī)治療的基礎(chǔ)上加用血必凈注射液治療,連續(xù)用藥7 d。取10名身體健康的人員作為正常對照組。比較對照組和治療組患者治療前后體溫、白細胞計數(shù)(WBC)、C反應蛋白(CRP)、動脈血氧分壓[pa(O_2)]和動脈血氣分析氧合指數(shù)[pa(O_2)/Fi(O_2)]的變化。采用ELISA法測定并比較各組患者各時間點血漿中IL-6和TNF-α的水平。結(jié)果治療7 d后,治療組和對照組患者的體溫、WBC、CRP、pa(O_2)和pa(O_2)/Fi(O_2)均較治療前有明顯改善,差異顯著(P0.01)。治療組患者治療后各項指標均較對照組治療后有明顯改善,差異顯著(P0.05、0.01);對照組和治療組患者治療前后血漿中IL-6和TNF-α均明顯高于正常對照組。治療前,對照組和治療組患者血漿中IL-6、TNF-α的水平相比較,差異無統(tǒng)計學意義;兩組患者治療后3、7 d的IL-6和TNF-α水平均較治療前降低,治療組IL-6和TNF-α水平的下降程度較對照組同期更明顯,差異顯著(P0.05、0.01)。結(jié)論血必凈注射液可以降低重癥肺炎患者血漿中IL-6和TNF-α水平,對重癥肺炎患者有一定輔助治療作用。
[Abstract]:Objective to investigate the effect of Xuebijing injection on interleukin-6 (IL-6) and tumor necrosis factor- 偽 (TNF- 偽) in patients with severe pneumonia. Methods 100 patients with severe pneumonia were randomly divided into control group (50 cases) and treatment group (50 cases). Both groups were treated with routine western medicine. The treatment group was treated with Xuebijing injection on the basis of routine western medicine for 7 days. Ten healthy persons were taken as normal control group. The changes of body temperature, white blood cell count, (WBC) C-reactive protein (CRP), arterial partial pressure of oxygen [pa (O _ 2)] and arterial blood gas analysis were compared between the control group and the treatment group before and after treatment. The plasma levels of IL-6 and TNF- 偽 were measured and compared by ELISA. Results after 7 days of treatment, the body temperature of the patients in the treatment group and the control group were significantly improved compared with those before the treatment (P0.01). After treatment, the indexes of the patients in the treatment group were significantly improved compared with those in the control group (P0.05, 0.01), and the plasma levels of IL-6 and TNF- 偽 in the control group and the treatment group were significantly higher than those in the normal control group before and after treatment. Before treatment, the levels of IL-6 TNF- 偽 in plasma of patients in control group and treatment group were not significantly different, and the levels of IL-6 and TNF- 偽 in patients of both groups were lower than those before treatment. The levels of IL-6 and TNF- 偽 in the treatment group were significantly lower than those in the control group (P0.05 / 0. 01). Conclusion Xuebijing injection can reduce the levels of IL-6 and TNF- 偽 in plasma of patients with severe pneumonia.
【作者單位】： 武警后勤學院附屬醫(yī)院腦科醫(yī)院武警部隊腦創(chuàng)傷與神經(jīng)疾病研究所天津市神經(jīng)創(chuàng)傷修復重點實驗室;天津北辰醫(yī)院神經(jīng)外科;武警后勤學院附屬醫(yī)院呼吸與重癥醫(yī)學科;
【基金】：國家自然科學基金資助項目(81271392) 天津市自然科學基金資助項目(12JCYBJC18500)
【分類號】：R563.1

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