發(fā)布時間：2018-06-28 07:12

  本文選題：營養(yǎng)不良 + 肺疾病�。� 參考：《中國現(xiàn)代醫(yī)學雜志》2014年17期

【摘要】：目的觀察慢性阻塞性肺疾病(COPD)患者外周血中血清肌抑素水平的變化,探討肌抑素與COPD患者營養(yǎng)不良的關系。方法選取COPD穩(wěn)定期住院患者76例及健康對照者80例,通過營養(yǎng)不良參數(shù)評分(MNI)對所有受試者進行營養(yǎng)狀況評價,并采取酶聯(lián)免疫吸附法檢測各組受試者血清中的肌抑素及腫瘤壞死因子-α(TNF-α)水平。結果 COPD組患者的MNI分值高于健康對照組,差異均有統(tǒng)計學意義(P0.01)。其中COPD組MNI分值≥5分者占81.6%(62/76),MNI分值5分者僅占18.4%(14/76)。COPD組患者的肌抑素及TNF-α水平均顯著高于健康對照組(P0.05)。COPD組患者血清肌抑素水平與MNI評分及TNF-α水平呈正相關(r=0.425,P=0.015;r=0.484,P=0.03)。結論多數(shù)COPD患者存在營養(yǎng)不良,其體內(nèi)血清肌抑素水平較同齡健康人明顯升高,肌抑素與COPD營養(yǎng)不良的發(fā)生關系密切。
[Abstract]:Objective to observe the changes of serum myostatin levels in patients with chronic obstructive pulmonary disease (COPD) and to explore the relationship between myostatin and malnutrition in COPD patients. Methods 76 inpatients with stable COPD and 80 healthy controls were selected to evaluate the nutritional status of all subjects by means of malnutrition parameter score (MNI). The serum levels of myostatin and tumor necrosis factor- 偽 (TNF- 偽) were detected by enzyme linked immunosorbent assay (Elisa). Results the MNI scores in COPD group were significantly higher than those in healthy control group (P 0.01). Among them, 81.6% (62 / 76) with MNI score 鈮，

本文編號：2077187