本文選題：CTD-ILD + IPAF��； 參考：《南昌大學(xué)》2017年碩士論文

【摘要】：背景:結(jié)締組織病(connective tissue disease,CTD)主要是指是一系列累及結(jié)締組織的疾病,分為狹義的結(jié)締組織及廣義的結(jié)締組織,一般以狹義的結(jié)締組織定義為主。主要包括:原發(fā)性干燥綜合癥等。IPAF為近年來提出新型概念,為介于ITP與CTD-ILD之間的病,具有特征性的臨床特點(diǎn),但無法診斷CTD,有學(xué)者認(rèn)為,可能為CTD早期階段,加上CTD-ILD發(fā)病率以及死亡率逐年上升,早期發(fā)現(xiàn)IPAF變得尤為重要。目的:通過分析結(jié)締組織病相關(guān)性間質(zhì)性肺病CTD-ILD與IPAF的臨床表現(xiàn)、影像學(xué)、病理學(xué)、自身抗體等特點(diǎn)及治療特征,探討各自臨床特征,便于以后相關(guān)疾病的診療。方法:以“CTD-ILD,IPAF、結(jié)締組織病、間質(zhì)性肺病、SSc、SLE、NSIP“等關(guān)鍵詞進(jìn)行檢索,找出關(guān)于CTD-ILD、IPA等方面的相關(guān)研究,從臨床表現(xiàn)、影像學(xué)、病理學(xué)、自身抗體、治療等方面進(jìn)行分析,最后總結(jié)。結(jié)果與結(jié)論:IPAF為一類具有CTD-ILD疾病特征,根據(jù)國內(nèi)外研究分析,及臨床分析,我們發(fā)現(xiàn)在一些診斷為特發(fā)性肺間質(zhì)纖維化的患者中,并非單純的ITP,在很多方面具有ITP沒有的特征,但是又無法診斷為風(fēng)濕免疫性疾病。并且認(rèn)識到它介于特發(fā)性間質(zhì)性肺病與結(jié)締組織疾病相關(guān)間質(zhì)性肺病中間,可能為CTD前期,可能較CTD-ILD進(jìn)展慢,可能預(yù)后較好,需要我們更多的探索。
[Abstract]:Background: connective tissue disease (connective tissue) is a series of diseases involving connective tissue, which is divided into narrow sense connective tissue and broad sense connective tissue. IPAF is a new concept proposed in recent years, which is a disease between ITP and CTD-ILD. It has characteristic clinical characteristics, but it can not diagnose CTD. Some scholars believe that it may be the early stage of CTD. Combined with the increasing incidence and mortality of CTD-ILD, early detection of IPAF becomes particularly important. Objective: to investigate the clinical features of CTD-ILD and IPAF in the diagnosis and treatment of connective tissue disease related interstitial pulmonary disease (CTD-ILD). Methods: by using the keywords of "CTD-ILDU IPAF, connective tissue disease, interstitial pulmonary disease SLESLENSIP", the relevant research on CTD-ILDNP-IPA was found, and the clinical manifestation, imaging, pathology, autoantibody and treatment were analyzed and summarized. Results and conclusion: IPAF is a kind of CTD-ILD disease. According to domestic and foreign studies and clinical analysis, we found that in some patients diagnosed as idiopathic pulmonary interstitial fibrosis, it is not a simple ITP.It has the characteristics that ITP does not exist in many aspects. But it is impossible to diagnose rheumatic immune disease. It is also recognized that it is between idiopathic interstitial pulmonary disease and connective tissue disease related interstitial pulmonary disease, which may be preCTD, may progress slower than CTD-ILD, may have a better prognosis, and needs more exploration.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R593.2;R563

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