本文選題：高原 + 傳染病監(jiān)測��； 參考：《中國病原生物學雜志》2014年05期

【摘要】：目的了解青海省急性呼吸道感染常見病原,探討高原地區(qū)發(fā)熱呼吸道癥候群的病原譜構成。方法采集急性呼吸道感染患者的呼吸道分泌物、血液和尿液標本,用多重RT-PCR方法對標本進行9種細菌(支原體、衣原體)和7種病毒核酸檢測。結果受檢患者329例,細菌(支原體、衣原體)陽性率為5.86%(19/324),病毒陽性率為14.94%(46/308),差異有統(tǒng)計學意義(χ2=14.08,P0.01)。檢出的細菌主要為肺炎鏈球菌(占47.37%),其次為肺炎克雷伯菌(占31.58%);檢出的病毒主要為人腺病毒(占31.25%),其次為人副流感病毒(占27.08%)。男性患者病原體核酸陽性率為21.26%(44/207),女性患者為13.93%(17/122),差異無統(tǒng)計學意義(χ2=2.72,P0.05)。結論青海高原地區(qū)急性呼吸道感染病原主要為人腺病毒、副流感病毒、流感病毒、肺炎鏈球菌和肺炎克雷伯菌,且病毒性呼吸道疾病所占比例較大,提示高原地區(qū)發(fā)熱呼吸道感染病原以病毒為主。
[Abstract]:Objective to investigate the common pathogens of acute respiratory tract infection (ARI) in Qinghai Province and to explore the pathogenic spectrum of febrile respiratory syndrome (FRS) at high altitude. Methods Respiratory secretions, blood and urine samples were collected from patients with acute respiratory tract infection. 9 strains of bacteria (mycoplasma, chlamydia) and 7 viral nucleic acids were detected by multiplex RT-PCR. Results in 329 patients, the positive rate of bacteria (mycoplasma, chlamydia) was 5.86 / 324, and the positive rate of virus was 14.9446 / 308, the difference was statistically significant (蠂 2, 14.08, P 0.01). The main bacteria detected were Streptococcus pneumoniae (47.37%), Klebsiella pneumoniae (31.58%), human adenovirus (31.25%) and parainfluenza virus (27.08%). The positive rate of pathogen nucleic acid was 21.26% in male patients and 13.93% in female patients. The difference was not statistically significant (蠂 2 + 2.72% P 0.05). Conclusion Human adenovirus, parainfluenza virus, Streptococcus pneumoniae and Klebsiella pneumoniae are the main pathogens of acute respiratory tract infection in Qinghai Plateau. It is suggested that the main pathogen of fever and respiratory tract infection in plateau area is virus.
【作者單位】： 青海省疾病預防控制中心;
【基金】：國家“十一五”科技重大專項(No.2009ZX10004-208)
【分類號】：R56

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本文編號：2020797