本文選題：結(jié)核 + 耐藥�。� 參考：《重慶醫(yī)學(xué)》2014年22期

【摘要】：目的分析評(píng)價(jià)重慶市主城區(qū)肺結(jié)核耐藥情況,為下一步耐藥防治工作提出建議。方法對(duì)主城區(qū)2009年9月至2010年6月期間新登記的涂陽肺結(jié)核患者進(jìn)行問卷調(diào)查,同時(shí)開展患者痰培養(yǎng)、藥敏試驗(yàn)等相關(guān)實(shí)驗(yàn)室檢測(cè),對(duì)結(jié)果進(jìn)行分析。結(jié)果主城區(qū)涂陽肺結(jié)核患者總耐藥率、耐多藥率分別為27.62%、10.50%,初治、復(fù)治患者耐多藥率分別為6.99%、23.68%;181例肺結(jié)核患者耐藥率順序?yàn)楫悷熾?H)為19.34%、鏈霉素(S)為18.23%、利福平(R)為13.26%、乙胺丁醇(E)為11.05%、氧氟沙星(Ofx)為6.08%、卡那霉素(Km)為2.21%;50例耐藥患者中,共計(jì)有20種結(jié)核病耐藥譜型;男性、既往接受過抗結(jié)核治療、咳嗽咳痰大于等于2周在耐藥和非耐藥肺結(jié)核患者間差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論重慶市主城區(qū)肺結(jié)核耐藥疫情形勢(shì)嚴(yán)峻,應(yīng)將耐藥監(jiān)測(cè)工作日�；�,同時(shí)關(guān)注可能產(chǎn)生耐藥的相關(guān)因素。
[Abstract]:Objective to analyze and evaluate the drug resistance of pulmonary tuberculosis (TB) in main urban area of Chongqing, and to provide suggestions for the prevention and treatment of drug resistance in the next step. Methods A questionnaire survey was conducted among the newly registered smear positive pulmonary tuberculosis patients from September 2009 to June 2010 in the main urban area. The results were analyzed by laboratory tests such as sputum culture and drug sensitivity test. Results the total drug resistance rate and multidrug resistance rate of smear positive pulmonary tuberculosis patients in the main urban area were 27.6210.50, respectively. The multidrug resistance rates of patients with recurrent treatment were 6.99, 23.68 and 181 cases of pulmonary tuberculosis, respectively. The order of drug resistance was isoniazid (H), streptomycin (S), rifampicin (R), rifampicin, ethambutanol, ofloxacin, kanamycin and kanamycin, respectively, and 19.34, 18.23, 13.26, 11.05, 6.08, 6.08 and 2.21%, respectively. There were 20 types of drug resistance in tuberculosis, male, who had been treated with anti-tuberculosis, cough and expectoration were more than 2 weeks, there was significant difference between drug resistant and non-drug resistant pulmonary tuberculosis patients (P 0.05). Conclusion the situation of drug resistance of pulmonary tuberculosis in Chongqing is serious, so it is necessary to monitor drug resistance and pay attention to the related factors of drug resistance.
【作者單位】： 重慶市結(jié)核病防治所區(qū)縣防治科;
【基金】：國家科技重大專項(xiàng)基金資助項(xiàng)目(2008ZX10003008-002-008)
【分類號(hào)】：R521

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