本文選題：哮喘 + 凝血功能��； 參考：《新疆醫(yī)科大學(xué)》2013年碩士論文

【摘要】：目的：通過對不同病程的哮喘患者凝血功能的比較，了解不同病程哮喘患者的凝血功能特點及是否存在差異，分析可能造成哮喘患者凝血功能改變的原因，為調(diào)節(jié)凝血功能的相關(guān)治療應(yīng)用于哮喘提供理論依據(jù)。方法：采用回顧性病例對照研究的方法，收集符合納入及排除標(biāo)準(zhǔn)選取的222例患者的臨床資料包括年齡、性別、病程長短及PT、INR、FIB、APTT、TT等數(shù)據(jù)。根據(jù)病程長短分為3組，，然后再將各組按年齡各分為老年組和非老年組，并對各組上述指標(biāo)進(jìn)行兩兩比較。結(jié)果：病程達(dá)10年以上哮喘患者凝血功能與不足1年患者相比，病程在1-9年之間的患者，各項指標(biāo)均有統(tǒng)計學(xué)差異（P＜0.05），提示血栓前狀態(tài)加重。而病程在1-9年之間的患者與不足1年患者相比PT、INT、TT減低。在非老年患者中，病程達(dá)10年以上的患者FIB增加、TT縮短有統(tǒng)計學(xué)意義；而老年患者FIB、TT差異無統(tǒng)計學(xué)意義。結(jié)論：支氣管哮喘患者的病程延長與高凝狀態(tài)不斷加重存在相關(guān)性；各組間PT、PTA、INR比較均有統(tǒng)計學(xué)差異，考慮可能是肺部局部凝血功能變化導(dǎo)致的全身外源性凝血途徑敏感性增高引起；在各非老年患者組中，凝血功能變化較為明顯，病程達(dá)10年以上患者FIB增加、APTT、TT縮短等改變較為明顯；而在老年患者中FIB增加、TT縮短則不明顯。哮喘患者存在高凝狀態(tài)并伴隨病程進(jìn)展進(jìn)一步加重，提示應(yīng)考慮給予哮喘患者適當(dāng)?shù)目鼓委�，繼而更好的控制哮喘，延緩病程進(jìn)展，避免或減輕其并發(fā)癥，提高患者生存質(zhì)量。
[Abstract]:Objective: to compare the coagulation function of asthmatic patients with different course of disease, to understand the characteristics of coagulation function and whether there are differences in different course of asthma, and to analyze the possible causes of the change of coagulation function in asthmatic patients. To provide theoretical basis for the application of clotting related therapy in asthma. Methods: a retrospective case-control study was conducted to collect data of 222 patients, including age, sex, duration of disease and APTTTT, which were selected according to the criteria of inclusion and exclusion. According to the duration of the disease, each group was divided into three groups, and then each group was divided into the old group and the non-elderly group according to the age, and the above indexes were compared in two groups. Results: the coagulation function of asthmatic patients with a course of more than 10 years was significantly higher than that of patients with less than one year (P < 0.05). Patients with a course of 1-9 years had lower PTT TT than those with less than one year. In non-elderly patients, the increase of FIB in patients with a course of more than 10 years was statistically significant, but there was no significant difference in FIBTT between elderly patients and elderly patients. Conclusion: there is a correlation between the prolongation of the course of the disease and the exacerbation of hypercoagulability in patients with bronchial asthma. It may be that the sensitivity of systemic exogenous coagulation pathway is increased due to the changes of pulmonary local coagulation function, and the change of coagulation function is more obvious in all non-elderly patients. The increase of FIB and the shortening of APTT TT were more obvious in the patients with the course of more than 10 years, but not in the elderly patients. The hypercoagulable state of asthmatic patients and the further aggravation of the course of the disease suggest that appropriate anticoagulant therapy should be taken into account in order to better control the asthma, delay the progression of the disease, and avoid or reduce the complications. Improve the quality of life of patients.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R562.25

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