本文選題：呼出氣一氧化氮 + 支氣管哮喘�。� 參考：《中南大學學報(醫(yī)學版)》2014年04期

【摘要】：目的:探討呼出氣一氧化氮水平(fractional exhaled nitric oxide,FeNO)在支氣管哮喘、慢性阻塞性疾病(chronic obstructive pulmonary diseases,COPD)中的變化情況及與肺功能中第1秒用力呼氣量(forced expiratory volume in the first second,FEV1)、第1秒用力呼氣量占用力肺活量的百分比(forced expiratory volume in the first second/forced vital capacity,FEV1/FVC)的相關性。方法:選取57例疑似支氣管哮喘患者(21例為急性發(fā)作期、12例為非急性發(fā)作期、24例為非支氣管哮喘)、38例COPD患者(25例為急性加重期、13例為穩(wěn)定期)、26例正常對照者,分別測定FeNO,FEV1,FEV1/FVC,并進行統(tǒng)計學分析。結(jié)果:在FeNO診斷支氣管哮喘中,若FeNO以20.15 PPb為切點,57例疑似支氣管哮喘患者診斷為支氣管哮喘的陽性預測值94.1%,陰性預測值95.7%,靈敏度97.0%,特異度91.7%;33例確診為支氣管哮喘患者的FeNO與26例正常對照者比較,差異有統(tǒng)計學意義(P0.05);支氣管哮喘非急性發(fā)作期患者FeNO較急性期顯著下降,差異有統(tǒng)計學意義(P0.05),FEV1和FEV1/FVC差異無統(tǒng)計學意義(P0.05);支氣管哮喘患者FeNO水平與FEV1和FEV1/FVC無明顯相關性(r=-0.186,-0.236,均P0.05);38例COPD患者的FeNO,FEV1,FEV1/FVC與26例正常對照者比較,差異有統(tǒng)計學意義(均P0.05);25例COPD急性加重期患者FeNO,FEV1,FEV1/FVC與13例COPD穩(wěn)定期比較,差異有統(tǒng)計學意義(均P0.05);13例COPD穩(wěn)定期患者FeNO與正常對照者比較,差異無統(tǒng)計學意義(P0.05);COPD患者FeNO水平與FEV1和FEV1/FVC無明顯相關性(r=-0.167,-0.285,均P0.05)。結(jié)論:支氣管哮喘患者FeNO水平顯著升高,在用FeNO診斷支氣管哮喘中,若FeNO以20.15 PPb為切點,則FeNO診斷該疾病有較高的靈敏度和特異性;急性發(fā)作期FeNO較非急性發(fā)作期明顯升高,可用于評估支氣管哮喘的控制程度。COPD患者FeNO在急性加重期升高,穩(wěn)定期無明顯升高。
[Abstract]:Objective : To investigate the changes of nitric oxide ( NO ) in bronchial asthma , chronic obstructive pulmonary diseases ( COPD ) and the relationship between forced expiratory volume in the first second ( FEV1 ) and forced expiratory volume in the first second ( forced expiratory volume in the first second / forced vital capacity , FEV1 / FVC ) . There was no significant difference in FEV1 and FEV1 / FVC between patients with COPD ( P0.05 ) ; FeNO , FEV1 , FEV1 / FVC in 38 patients with COPD were statistically significant ( P0.05 ) ; Conclusion : The level of FeNO in patients with bronchial asthma is significantly higher than that of FeNO in the diagnosis of bronchial asthma . FeNO can diagnose the disease with high sensitivity and specificity if FeNO is 20 . 15 PPb .
【作者單位】： 中南大學湘雅醫(yī)院呼吸與危重癥醫(yī)學科;
【基金】：國家自然科學基金(81170023)~~
【分類號】：R563.9;R562.25

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