本文選題：阿托伐他汀 + 慢性阻塞性肺疾病��； 參考：《中國藥房》2017年33期

【摘要】：目的:系統(tǒng)評價阿托伐他汀對穩(wěn)定期慢性阻塞性肺疾病(COPD)患者肺功能、肺動脈壓及相關指標的影響,為臨床提供循證參考。方法:計算機檢索Cochrane圖書館、PubMed、EMBase、相關期刊論文、中文科技期刊數(shù)據(jù)庫,收集阿托伐他汀聯(lián)合常規(guī)基礎方案(試驗組)對比單純常規(guī)基礎方案(對照組)治療穩(wěn)定期COPD的隨機對照試驗(RCT),提取資料并按照Cochrane系統(tǒng)評價員手冊5.1.0評價質(zhì)量后,采用Rev Man 5.3統(tǒng)計軟件進行Meta分析。結(jié)果:共納入7項RCT,合計371例患者。Meta分析結(jié)果顯示,試驗組患者第1秒用力呼氣容積[MD=0.07,95%CI(0.04,0.09),P0.001]、第1秒用力呼氣容積占預計值百分比[MD=6.18,95%CI(2.23,10.12),P=0.002]、6分鐘步行距離[MD=55.31,95%CI(36.44,74.18),P0.001]均顯著高于/長于對照組,肺動脈收縮壓[MD=-6.78,95%CI(-11.62,-1.94),P=0.006]、平均肺動脈壓[MD=-6.61,95%CI(-7.26,-5.96),P0.001]、圣喬治呼吸問卷評分[MD=-13.21,95%CI(-23.90,-2.52),P=0.02]均顯著低于對照組,差異均有統(tǒng)計學意義;兩組患者第1秒用力呼氣容積占用力肺活量比值[MD=3.73,95%CI(-2.08,9.55),P=0.21]和高敏C反應蛋白水平[MD=0.29,95%CI(-1.37,1.95),P=0.73]比較,差異均無統(tǒng)計學意義。結(jié)論:阿托伐他汀用于穩(wěn)定期COPD患者可以顯著改善患者肺功能和肺動脈壓,提高患者生活質(zhì)量。
[Abstract]:Objective: to evaluate the effects of Atto vastatin on pulmonary function, pulmonary artery pressure and related indexes in patients with stable chronic obstructive pulmonary disease (COPD). Methods: Cochrane library was searched by computer. A randomized controlled trial of Atto vastatin combined with conventional basic regimen (trial group) was collected for the treatment of stable COPD in comparison with the control group. The data were extracted and the quality was evaluated according to the Cochrane system evaluator's manual 5.1.0. Meta analysis was carried out with Rev Man 5.3. Results: a total of 371 RCTs were included. Meta-analysis showed that the forced expiratory volume in the first second [MD0.07 ~ 95CII 0.04 ~ 0.09], the percentage of the predicted value in the first second [MD6.181.95CI2.2310.12P0.002] 6-minute walking distance [MD55.3195% CI36.444.18P0.001] were significantly higher than / longer than those in the control group. Pulmonary arterial systolic pressure (MPP) was significantly lower than that in the control group (P 0.001). The mean pulmonary arterial pressure (MPAP) was significantly lower than that in the control group (P 0.001). The score of St. George's Respiratory questionnaire was significantly lower than that in the control group (P < 0.01). The mean pulmonary artery pressure was significantly lower than that in the control group (P 0.001). The score of St. George's Respiratory questionnaire was significantly lower than that in the control group (P 0.001). There was no significant difference between the two groups in the ratio of forced expiratory volume occupying capacity to vital capacity in the first second [MDT 3.73N 95] and Gao Min C-reactive protein level (MDT 0.2995 CI-1.371.95 P0. 73). Conclusion: Atto vastatin can significantly improve pulmonary function, pulmonary artery pressure and quality of life in patients with stable COPD.
【作者單位】： 鎮(zhèn)江市第一人民醫(yī)院老年科;江蘇大學附屬醫(yī)院檢驗科;
【基金】：江蘇大學醫(yī)學臨床科技發(fā)展基金資助項目(No.JLY20120169)
【分類號】：R563.9

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