本文選題：慢性阻塞性肺疾病 + 穩(wěn)定期　； 參考：《山東醫(yī)藥》2017年25期

【摘要】：目的探討吸煙對(duì)慢性阻塞性肺疾病(COPD)穩(wěn)定期患者血清IL-6、IL-18、Clara細(xì)胞分泌蛋白(CC16)水平及營(yíng)養(yǎng)狀況的影響。方法收集COPD穩(wěn)定期患者200例(COPD組)和同期體檢健康者100例(對(duì)照組)的病史資料、微型營(yíng)養(yǎng)評(píng)定(MNA)結(jié)果并對(duì)所有受試者行肺功能檢查;用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測(cè)受試者血清IL-6、IL-18、CC16水平。根據(jù)受試者的吸煙史,選取COPD組中吸煙者作為COPD吸煙亞組;對(duì)照組中吸煙者作為正常吸煙亞組,未吸煙者作為正常未吸煙亞組。在COPD吸煙亞組中根據(jù)吸煙指數(shù)(SI)進(jìn)一步分為SI400亞組與SI≥400亞組,對(duì)吸煙COPD穩(wěn)定期患者的SI、MNA值與血清IL-6、IL-18、CC16進(jìn)行Spearman相關(guān)性分析。結(jié)果COPD組與對(duì)照組受試者性別構(gòu)成比、年齡、吸煙指數(shù)等差異無(wú)統(tǒng)計(jì)學(xué)意義(P均0.05);COPD組第1秒用力呼氣容積(FEV_1)、FEV_1占用力肺活量的百分比(FEV_1/FVC)%、CC16濃度、MNA值均低于對(duì)照組,而血清IL-6、IL-18水平均高于對(duì)照組,P均0.01。與正常未吸煙亞組相比,正常吸煙亞組、COPD吸煙亞組血清IL-6、IL-18水平均升高,而CC16水平降低;COPD吸煙亞組血清IL-6、IL-18水平高于正常吸煙亞組,而CC16水平低于正常吸煙亞組,差異均有統(tǒng)計(jì)學(xué)意義(P均0.05)。SI≥400亞組血清IL-6、IL-18水平高于SI400亞組,而CC16水平及MNA值均低于SI400亞組,以上差異均有統(tǒng)計(jì)學(xué)意義(P均0.05)。相關(guān)性分析結(jié)果顯示,吸煙COPD穩(wěn)定期患者的SI與血清IL-6、IL-18水平呈正相關(guān)(r分別為0.443、0.338,P均0.01),與CC16水平呈負(fù)相關(guān)(r=-0.423,P0.01);SI與MNA值呈負(fù)相關(guān)(r=-0.304,P0.05);MNA值與血清IL-6、IL-18水平均呈負(fù)相關(guān)(r分別為-0.485、-0.291,P均0.05),而與CC16水平無(wú)相關(guān)性(r=0.111,P=0.289)。結(jié)論吸煙可致COPD穩(wěn)定期患者血清IL-6、IL-18水平升高、CC16水平降低,能增加COPD患者發(fā)生營(yíng)養(yǎng)不良的風(fēng)險(xiǎn),且與吸煙量有正相關(guān)關(guān)系。
[Abstract]:Objective to investigate the effect of smoking on the level and nutritional status of IL-18 Clara cell secretory protein CC16 in patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods the history data of 200 patients with stable COPD and 100 healthy persons (control group) were collected, and the results of mini-nutrition evaluation were collected, and lung function tests were performed on all subjects. The serum levels of IL-6 and IL-18 CC16 were measured by enzyme linked immunosorbent assay (Elisa). According to the smoking history of the subjects, smokers in the COPD group were selected as the COPD smoking subgroup, while the smokers in the control group as the normal smoking subgroup and the non-smokers as the normal non-smoking subgroup. According to smoking index (SI), COPD smoking subgroup was further divided into SI400 subgroup and SI 鈮，

本文編號(hào)：1798475